refine search
protein tyrosine/serine/threonine phosphatase activity 37
 
Dual Specificity Phosphatase 1 29
 
MAP Kinase Signaling System 38
 
Phosphorylation 47
 
Mitogen-Activated Protein Kinase 1 27
 
MP kinase activity 27
 
JUN kinase activity 26
 
dephosphorylation 25
 
MAP kinase 1 activity 25
 
Protein Phosphatase 2 20
 
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
160 documents found
1: Title: MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Authors: Xue, Zheng, et.al. .
Journal: Cell research (Cell Res), 2018 .
Snippet: We show here that MEK inhibition activates JNK-JUN signaling through suppression of DUSP4, leading to activation of HER Receptor Tyrosine Kinases.
Affiliation: Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. Department of Oncology and Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, CB2 0RE, UK. Cambridge Breast Unit, NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 2QQ, UK. Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. r.bernards@nki.nl. .
Related Products: order online
2: Title: Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Authors: Choi, Jason C, et.al. .
Journal: Human molecular genetics (Hum Mol Genet), 2018 .
Snippet: We now show that female LmnaH222P/H222P mice, a model for LMNA cardiomyopathy, have increased Dusp4 expression and hyperactivation of extracellular signal-regulated kinase (ERK) 1/2 with delayed kinetics relative to male mice, consistent with the sex-dependent delay in the onset and progression of disease.
Affiliation: Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Department of Medicine. Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom. .
Related Products: order online
3: Title: A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance.
Authors: Matthews, James H, et.al. .
Journal: ACS chemical biology (Acs Chem Biol), 2018 .
Snippet: Moreover, we have identified a set of putative Nrf2 targets comprising the transcription factors TWIST1 and ELF4, the protein kinase NEK8, the TAK1 kinase regulator TAB1, and the dual specific phosphatase DUSP4.
Affiliation: Smithsonian Marine Station , 701 Seaway Drive , Fort Pierce , Florida 34949 , United States. .
Related Products: order online
4: Title: MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4.
Authors: Xu, Xiaofeng, et.al. .
Journal: Cancer biology & therapy (Cancer Biol Ther), 2018 .
Snippet: Bioinformatics prediction strategies and dual luciferase reporter assay verified the binding sites of miR-122-5p on 3'UTR of DUSP4 and the target relationship between miR-122-5p and DUSP4.
Affiliation: a Department of Laboratory Medicine , Jingjiang People's Hospital , Jingjiang , Jiangsu , China. b Department of Gastroenterology , Jingjiang People's Hospital , Jingjiang , Jiangsu , China. c Department of Central Laboratory , Jingjiang People's Hospital , Jingjiang , Jiangsu , China. d Department of Science and Education , Jingjiang People's Hospital , Jingjiang , Jiangsu , China. .
Related Products: order online
5: Title: Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patients.
Authors: Arvidsson, Gustav, et.al. .
Journal: Haematologica, 2018 .
Snippet: From these genes we suggest a core set of genes (CCL3, CCL4, DUSP4, ETV5, ICAM1, IL15RA, IL21R, IL4I1, MFSD2A, NFKB1, NFKBIE, SEMA7A, TMEM2) characteristic of cells undergoing cell-adhesion mediated microenvironment signaling in mantle cell lymphoma/chronic lymphocytic leukemia.
Affiliation: Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; anthony.wright@ki.se. .
Related Products: order online
6: Title: Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Authors: Lu, Jiajie George, et.al. .
Journal: Experimental and molecular pathology (Exp Mol Pathol), 2018 .
Snippet: The proteins tested were presented at the 2017 American Association for the Study of Liver Diseases (AASLD) Liver Meeting as overexpressed in hepatocellular carcinoma: KLF4, SCL19A1, FANCG, HRH-1, DNMT1, DNMT3B, TNFR2, DUSP4, EGFR, Integrin α6, HDACII, PDE3A, BCL-XL, and MTCO2.
Affiliation: Harbor UCLA Medical Center, 1000 W Carson St., Torrance, CA 90502, United States. Harbor UCLA Medical Center, 1000 W Carson St., Torrance, CA 90502, United States. Electronic address: sfrench@labiomed.org. .
Related Products: order online
7: Title: Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages.
Authors: van Boxtel, Antonius L, et.al. .
Journal: Developmental cell (Dev Cell), 2017 .
Snippet: We show that Nodal induces long-range Fgf signaling while simultaneously inducing the cell-autonomous Fgf signaling inhibitor Dusp4 within the first two cell tiers from the margin.
Affiliation: Developmental Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Developmental Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: caroline.hill@crick.ac.uk. .
Related Products: order online
8: Title: DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition.
Authors: Kang, Xing, et.al. .
Journal: Oncotarget, Vol. 8 (55): 94028-94039, 2017 .
Snippet: The expression of DUSP4, E-cadherin and Vimentin protein was detected by Western blotting.
Affiliation: Department of General Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China. Department of Laboratory Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu Province, China. Department of Gastroenterology, The Afflicted Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China. .
Related Products: order online
9: Title: Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.
Authors: Badodi, Sara, et.al. .
Journal: Cell reports (Cell Rep), Vol. 21 (10): 2772-2784, 2017 .
Snippet: We provide evidence that repression of the ERK inhibitor DUSP4 by BMI1 is dependent on a more accessible chromatin configuration in G4 MB cells with low CHD7 expression.
Affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, ON M5G 1L7, Canada. Pediatric Neurosurgery, Department of Surgery, McMaster Children's Hospital and McMaster Stem Cell & Cancer Research Institute, MDCL 5027, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada. Department of Craniofacial Development and Stem Cell Biology, King's College London, Floor 27, Guy's Hospital Tower Wing, London SE1 9RT, UK. Texas Children's Cancer Centre, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, MC-3-3320, Houston, TX 77479, USA. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK. Electronic address: s.marino@qmul.ac.uk. .
Related Products: order online
10: Title: Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.
Authors: Ichimanda, Michihiro, et.al. .
Journal: Cancer science (Cancer Sci), Vol. 109 (1): 250-258, 2018 .
Snippet: Recently, we reported that constitutive activation of MAPK accompanied by downregulation of dual-specificity phosphatase 4 (DUSP4), a MAPK phosphatase, contributes to the progression of precursor lesions in the pancreas.
Affiliation: Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan. Department of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan. Department of Microbiology, Faculty of Medicine, Oita University, Oita, Japan. Division of Cell Signaling and Molecular Medicine, Institute of Medical Sciences, University of Tokyo, Tokyo, Japan. .
Related Products: order online
11: Title: Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
Authors: Chen, Ting, et.al. .
Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett), Vol. 27 (24): 5473-5480, 2017 .
Snippet: The microarray data showed that DUSP6, DUSP4, and FOSL1 were down-regulated in the sensitive cell lines with the compound treatment.
Affiliation: Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA. Division of Oncology of School of Medicine and Center for Investigational Therapeutics at Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA. Tolero Pharmaceuticals, Inc., 2975 Executive Parkway, Suite 320, Lehi, UT 84043, USA. Tolero Pharmaceuticals, Inc., 2975 Executive Parkway, Suite 320, Lehi, UT 84043, USA. Electronic address: dbearss@toleropharma.com. Division of Oncology of School of Medicine and Center for Investigational Therapeutics at Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA. Electronic address: hari@hci.utah.edu. .
Related Products: order online
12: Title: Immunomodulation of dual specificity phosphatase 4 during visceral leishmaniasis.
Authors: Parveen, Shabina, et.al. .
Journal: Microbes and infection (Microbes Infect), 2017 .
Snippet: DUSP4, an inducible protein has a substrate specificity toward ERK1/2, a component of MAP kinase which is enhanced during Leishmania infection.
Affiliation: Division of Molecular Medicine, Bose Institute, Kolkata 700 054, India. National Centre for Cell Science, Ganeshkhind, Pune 411 007, India. Division of Molecular Medicine, Bose Institute, Kolkata 700 054, India. Electronic address: subrata@jcbose.ac.in. .
Related Products: order online
13: Title: DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer.
Authors: Menyhart, Otília, et.al. .
Journal: Oncotarget, Vol. 8 (44): 77207-77218, 2017 .
Snippet: Higher expression for these correlated to worse survival (DUSP4: HR=2.05, p=0.009 and DUSP6: HR=2, p=0.0015).
Affiliation: Semmelweis University 2nd Department of Pediatrics, Budapest, Hungary. Institute of Pathology, Charité University Hospital, Berlin, Germany. Clinical Cancer Center, NYU Langone Medical Center, New York, NY, USA. New Terapeutics Targets Laboratory (TargetsLab), Department of Medical Sciences, University of Girona, Girona, Spain. MTA TTK Lendület Cancer Biomarker Research Group, Institute of Enzymology, Budapest, Hungary. .
Related Products: order online
14: Title: Proteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation  of one-carbon metabolic pathways.
Authors: Zhang, Kangling, et.al. .
Journal: Molecular & cellular proteomics : MCP (Mol Cell Proteomics), 2017 .
Snippet: We found that hypoxia affects cancer cells in multiple intertwined ways: inflammation, typically with over-expressed glucose transporter (GLUT1), DUSP4/ MKP2, and RelA proteins; a metabolic adaptation with overexpression of all glycolytic pathway enzymes for pyruvate/lactate synthesis; and the EMT (epithelial-mesenchymal transition) and cancer stem cell (CSC) renewal with characteristic morphological changes and mesenchymal/CSC protein expression profiles.
Affiliation: Pharmacology and Toxicology, University of Texas Madical Branch, United States of America kazhang@utmb.edu. Neuroscience and Cell biology, UTMB. UTMB. Univerisy of Texas Medical Branch, United States of America. Pharmacology, University of Texas Medical Branch. University of Texas Medical Branch. Institute for Translational Sciences, University of Texas Medical Branch. .
Related Products: order online
15: Title: Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes.
Authors: Chan, Ai-Leen, et.al. .
Journal: Stem cell reports, Vol. 9 (3): 956-971, 2017 .
Snippet: Mechanistically, SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4.
Affiliation: Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia. Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia. Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia; Systems Biology Institute Australia, Monash University, Melbourne, VIC 3800, Australia. Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, VIC 3800, Australia. Electronic address: robin.hobbs@monash.edu. .
Related Products: order online
16: Title: Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche.
Authors: Mills, Bradley N, et.al. .
Journal: Cancer microenvironment : official journal of the International Cancer Microenvironment Society (Cancer Microenviron), 2017 .
Snippet: Interrogation of the REpository for Molecular BRAin Neoplasia DaTa (REMBRANDT) revealed induction (DUSP4, DUSP6), repression (DUSP2, DUSP7-9), or mixed (DUSP1, DUSP5, DUSP10, DUSP15) DUSP transcription of select DUSPs in bulk tumor specimens.
Affiliation: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. Center for Neurotherapeutics Discovery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, NY, 14642, USA. Center for Neurotherapeutics Discovery, University of Rochester Medical Center, 601 Elmwood Avenue, Box 645, Rochester, NY, 14642, USA. Marc_Halterman@urmc.rochester.edu. Department of Neurology, University of Rochester Medical Center, Rochester, NY, 14642, USA. Marc_Halterman@urmc.rochester.edu. Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, 14642, USA. Marc_Halterman@urmc.rochester.edu. .
Related Products: order online
17: Title: Metalloprotease-dependent activation of EGFR modulates CD44(+)/CD24(-) populations in triple negative breast cancer cells through the MEK/ERK pathway.
Authors: Wise, Randi, et.al. .
Journal: Breast cancer research and treatment (Breast Cancer Res Treat), 2017 .
Snippet: Furthermore, our findings highlight the role of ligand-mediated EGFR signaling in the control of MEK/ERK pathway output in TNBC tumors without DUSP4 loss.
Affiliation: Department of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS, 66506, USA. Department of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS, 66506, USA. zolkiea@ksu.edu. .
Related Products: order online
18: Title: Nimbolide suppresses non-small cell lung cancer cell invasion and migration via manipulation of DUSP4 expression and ERK1/2 signaling.
Authors: Lin, Hua, et.al. .
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother), Vol. 92, 2017 .
Snippet: Therefore, nimbolide may act as a novel drug to inhibit NSCLC invasion and metastasis through manipulation of ERK1/2 signaling and DUSP4 expression.
Affiliation: Department of Respiratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, China. Department of Clinical Laboratory, The Xiangya Hospital of Central South University, Changsha 410008, Hunan, China. Department of Respiratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan, China. Electronic address: shenghuasunny@126.com. .
Related Products: order online
19: Title: Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis.
Authors: Ma, Yunlong, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7 (1): 1811, 2017 .
Snippet: Of these, genes such as DUSP4 and AKT3 are well documented as being involved in smoking-related lung cancer.
Affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, China. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. limd586@outlook.com. Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, China. limd586@outlook.com. Institute for NeuroImmune Pharmacology, Seton Hall University, South Orange, NJ, United States. limd586@outlook.com. .
Related Products: order online
20: Title: Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS.
Authors: Dougherty, Julie A, et.al. .
Journal: Frontiers in cardiovascular medicine (Front Cardiovasc Med), Vol. 4, 2017 .
Snippet: These results further support our hypothesis that DUSP4 is an antioxidant gene and a key phosphatase in modulating MAPKs, especially p38, during oxidative stress, which regulates ROS generation and eNOS expression and thus protects against oxidant-induced injury or apoptosis.
Affiliation: Department of Emergency Medicine, College of Medicine, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA. .
Related Products: order online
Page 1 2 3 … 8 
Documents per page: 20 | 50 | 100