refine search
dimethylargininase activity 83
 
Amidohydrolases 85
 
Nitric Oxide 75
 
nitric-oxide synthase activity 56
 
Endothelial Cells 42
 
Nitric Oxide Synthase Type III 22
 
RNA, Messenger 38
 
nitric-oxide synthase biosynthetic process 18
 
negative regulation of nitric-oxide synthase activity 16
 
Protein-Arginine N-Methyltransferases 13
 
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
125 documents found
1: Title: Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway.
Authors: Du, Mei-Rong, et.al. .
Journal: Vascular pharmacology (Vascul Pharmacol), 2018 .
Snippet: Administration of ADMA directly promoted proliferation, migration, adhesion and tube formation of RF/6A cells, which was further confirmed by DDAH1 siRNA or DDAH2 siRNA.
Affiliation: Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Departments of Pharmacy, The Affiliated Hospital of Southwest Medical University, Sichuan 646000, China. Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha 410078, China. Electronic address: junlinjiang@csu.edu.cn. .
Related Products: order online
2: Title: Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Authors: Xiao, Hong-Bo, et.al. .
Journal: Inflammation, Vol. 41 (1): 299-306, 2018 .
Snippet: The entire infused uterus were removed to observe the changes of histopathology, production of myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, 8-isoprostane, and reactive oxygen species (ROS), and gene expression of dimethylarginine dimethylaminohydrolase 2 (DDAH2), protein-methyl transferase 1 (PRMT1), TNF-α, and IL-6.
Affiliation: College of Veterinary Medicine, Hunan Agricultural University, Furong District, Changsha, 410128, China. xhbzhb@yahoo.com. College of Veterinary Medicine, Hunan Agricultural University, Furong District, Changsha, 410128, China. Hunan Province University Key Laboratory for Agricultural Biochemistry and Biotransformation, Hunan Agricultural University, Changsha, 410128, China. Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha, 410128, China. Biological Veterinary Drugs Branch, National Research Center of Engineering & Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, 410128, China. .
Related Products: order online
3: Title: Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy.
Journal: Nitric oxide : biology and chemistry (Nitric Oxide), Vol. 71, 2017 .
Snippet: We also studied genetic polymorphisms in DDAH1 and DDAH2 genes and their relation with biochemical and clinical data.
Affiliation: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil. Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Brazil. Department of General Biology, Biological Sciences Institute, Federal University of Minas Gerais, Brazil. Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Brazil. Department of Surgery and Anatomy, Ribeirao Preto Medical School, University of Sao Paulo, Brazil. Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy. Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Brazil. Electronic address: rlacchini@eerp.usp.br. .
Related Products: order online
4: Title: Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome.
Authors: Krishna, Meera B, et.al. .
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem), Vol. 43 (5): 1880-1892, 2017 .
Snippet: The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.
Affiliation: Female Reproduction and Metabolic Syndromes Laboratory, Division of Molecular Reproduction, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India. Research Scholar, Kerala University, Senate House Campus, Thiruvananthapuram, India. SAMAD -IVF Hospitals, Thiruvananthapuram, India. .
Related Products: order online
5: Title: Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity.
Authors: Lu, Chang-Wu, et.al. .
Journal: PloS one, Vol. 12 (7): e0179908, 2017 .
Snippet: Recombinant adenovirus encoding human DDAH2 gene were constructed and ex vivo transferred to isolated rat aortas.
Affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, P. R. China. Guangzhou Institute of Snake Venom Research, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China. Cancer Hospital and Cancer Research Institute of Guangzhou Medical University, Guangzhou, Guangdong, P. R. China. .
Related Products: order online
6: Title: Markers of nitric oxide are associated with sepsis severity: an observational study.
Journal: Critical care (London, England) (Crit Care), Vol. 21 (1): 189, 2017 .
Snippet: Plasma lArg, hArg, and ADMA concentrations were measured by mass spectrometry and peripheral blood mononuclear cells (PBMCs) were analyzed for DDAH2 expression.
Affiliation: Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. m.winkler@uke.de. Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. m.winkler@uke.de. Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. .
Related Products: order online
7: Title: Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis.
Authors: Wang, Tao, et.al. .
Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol), Vol. 44 (9): 961-964, 2017 .
Snippet: Our findings suggested that complex genetic variations in the DDAH2 gene may influence the ADMA concentration and erythropoietin resistance in MHD patients, in which altered oxidative stress was likely involved.
Affiliation: Department of Nephrology, Hebei General Hospital, Shijiazhuang, China. Department of Dermatology, Hebei Provincial Tumor Hospital, Shijiazhuang, China. .
Related Products: order online
8: Title: Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase.
Authors: Liu, Zhaoya, et.al. .
Journal: Redox biology (Redox Biol), Vol. 12, 2017 .
Snippet: Our previous study demonstrated that VPO1 plays a critical role in endothelial dysfunction through dimethylarginine dimethylaminohydrolase2 (DDAH2)/asymmetric Dimethylarginine (ADMA) pathway.
Affiliation: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Division of Pulmonary, Allergy & Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: xyzgg2006@sina.com. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: xyshiruizheng@csu.edu.cn. .
Related Products: order online
9: Title: Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits.
Authors: Lin, Yuan, et.al. .
Journal: European journal of pharmacology (Eur J Pharmacol), Vol. 798, 2017 .
Snippet: Recombinant DDAH2 gene adenoviruses were ex vivo transferred to thoracic aortas of high fat diet feeding rabbits.
Affiliation: Department of Pharmacology, Guangzhou Institute of Snake Venom Research, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, PR China. Department of Pharmacology, Cancer Research Institute, Cancer Hospital, Guangzhou Medical University, Guangzhou 510095, Guangdong, PR China. Department of Pharmacology, Guangzhou Institute of Snake Venom Research, Guangzhou Medical University, Guangzhou 511436, Guangdong, PR China; Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, PR China. Electronic address: Xiongyan2001@yahoo.com. .
Related Products: order online
10: Title: Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro.
Authors: Shoeibi, Sara, et.al. .
Journal: Cell biochemistry and function (Cell Biochem Funct), Vol. 35 (2): 69-76, 2017 .
Snippet: In addition, an efficient transfection with a plasmid vector (without risk of interference) can be constructed a hybrid structure with EPC and DDAH2 gene to examine their function in vitro.
Affiliation: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. .
Related Products: order online
11: Title: Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
Authors: Zhou, Ru, et.al. .
Journal: Cardiovascular therapeutics (Cardiovasc Ther), Vol. 35 (2), 2017 .
Snippet: Protective effects were evaluated by hemodynamic parameter, histopathological variables, serum asymmetric dimethylarginine (ADMA), cardiac troponin I (cTnI), brain natriuretic peptide (BNP) and myocardial nitric oxide (NO), and the levels of dimethylarginine dimethylaminohydrolase 2 (DDAH2), arginine methyltransferases 1 (PRMT1) and endothelial nitric oxide synthase (eNOS) expression were analyzed.
Affiliation: Department of Pharmacology, School of Pharmacy, Ningxia Medical University, Yinchuan, China. Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, China. Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan, China. Department of Cardiology, General Hospital of Ningxia Medical University, Yinchuan, China. .
Related Products: order online
12: Title: [Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia].
Authors: Gao, S L, et.al. .
Journal: Zhonghua xin xue guan bing za zhi, Vol. 44 (8): 700-6, 2016 .
Snippet: The mRNA expression of DNA methyl transferase 1 (DNMT1) and dimethyl arginine acid dimethylamine hydrolase 2 (DDAH2) in the mesenteric arteries were detected by real-time fluorescence quantitative PCR, and the protein expressions of DNMT1 and DDAH2 in the mesenteric arteries were detected by Western blot.
Affiliation: Department of Physiology, Fenyang College Shanxi Medical University, Fenyang 032200, China. .
Related Products: order online
13: Title: Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia.
Authors: Lambden, S, et.al. .
Journal: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society (Nitric Oxide), Vol. 58, 2016 .
Snippet: This study explored the metabolism of the endogenous inhibitor of nitric oxide production asymmetric dimethylarginine(ADMA) by monocyte dimethylarginine dimethylaminohydrolase 2(DDAH2), and the role of this pathway in the regulation of the cellular response and the local environment during hypoxia.
Affiliation: Nitric Oxide Signalling Group, Clinical Sciences Centre, MRC, Hammersmith Hospital, London, UK. Centre for Altitude, Space and Extreme Environment Medicine, UCL, London, UK. Nitric Oxide Signalling Group, Clinical Sciences Centre, MRC, Hammersmith Hospital, London, UK. Electronic address: james.leiper@csc.mrc.ac.uk. .
Related Products: order online
14: Title: Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis.
Authors: Lange, Clemens, et.al. .
Journal: Experimental eye research (Exp Eye Res), Vol. 147, 2016 .
Snippet: Finally, DDAH1(+/-) and DDAH2(-/-) deficient mice were studied in the oxygen-induced retinopathy (OIR) model, a model used to emulate retinal ischemia and neovascularization, and VEGF and ADMA levels were quantified by ELISA and liquid chromatography tandem mass spectrometry.
Affiliation: Department of Genetics, UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK; Eye Center, University Hospital Freiburg, Germany. Department of Genetics, UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK. The Nitric Oxide Signalling Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK. Institute of Pharmaceutical Science, King's College London, UK. Department of Genetics, UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK. Electronic address: j.bainbridge@ucl.ac.uk. .
Related Products: order online
15: Title: Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway.
Authors: Chen, Dong, et.al. .
Journal: Asian journal of andrology (Asian J Androl), Vol. 19 (3): 291-297, 2017 May-Jun .
Snippet: We found that DDAH1 and DDAH2 were expressed in cavernosal tissue, and they were downregulated in corpora of aged rats.
Affiliation: Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China. .
Related Products: order online
16: Title: GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells.
Authors: Tan, Yonghong, et.al. .
Journal: Neurotoxicology, Vol. 54, 2016 .
Snippet: Among them, three were up-expressed including ANXA6, GNB2 and STMN1, other three were down-expressed including ubiquitin-linke protein 7 (UBL7), DDAH2 and BLVRB.
Affiliation: Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong, China. Electronic address: yonghtan@hotmail.com. Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong, China. Electronic address: wangtans@hotmail.com. Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong, China. Electronic address: zhaobaisong819@163.com. Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong, China. Electronic address: yjsheh@yeah.net. Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong, China. Electronic address: bobjuan@sina.cn. .
Related Products: order online
17: Title: Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
Authors: Wu, Yan, et.al. .
Journal: Journal of cardiovascular pharmacology and therapeutics (J Cardiovasc Pharmacol Ther), Vol. 21 (6): 536-548, 2016 .
Snippet: The rats were fed with high-fat diet for 8 weeks to establish a hyperlipidemic model, which showed an increase in plasma lipids and endothelial injury, accompanied by an elevation in myosin light chain kinase (MLCK) activity, phosphorylated nmMLC20 (p-nmMLC20) level, and asymmetric dimethylarginine (ADMA) content as well as a reduction in DDAH2 expression, DDAH activity, and nitric oxide (NO) content.
Affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China. Department of Laboratory Medicine, Xiangya School of Medicine, Central South University, Changsha, China. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China Hunan Provincial Key Laboratory of Cardiovascular Research, School of Pharmaceutical Sciences, Central South University, Changsha, China. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China Hunan Provincial Key Laboratory of Cardiovascular Research, School of Pharmaceutical Sciences, Central South University, Changsha, China Junpeng@csu.edu.cn yzhichun@126.com. .
Related Products: order online
18: Title: N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice.
Authors: Jiang, Nan, et.al. .
Journal: Molecular nutrition & food research (Mol Nutr Food Res), Vol. 60 (7): 1625-36, 2016 .
Snippet: Mechanically, this could be attributed to a direct modulation of the methylation level of DDAH2 gene promoter region by MNA.
Affiliation: Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, P. R. China. .
Related Products: order online
19: Title: Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China.
Authors: Wang, Zhong, et.al. .
Journal: São Paulo medical journal = Revista paulista de medicina (Sao Paulo Med J), Vol. 134 (3): 205-10, 2016 .
Snippet: We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uygur), to systemically investigate associations between variations in the genes DDAH1 and DDAH2 and hypertension.
Affiliation: MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China. MD. Head of Department, Department of Cardiology, First Affiliated Hospital, Shihezi Medical College, Shihezi University, Shihezi, China. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. MD. Doctoral Student, Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. MD. Head of Department, Department of Cardiology, The People 's Hospital of Boertala, Bole, China. .
Related Products: order online
20: Title: Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia.
Authors: Xu, X, et.al. .
Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol), Vol. 196, 2016 .
Snippet: Compared with the control mice, Ddah1, Ddah2 and eNos mRNA were expressed at lower levels, and Cbs and Cse mRNA were expressed at significantly higher levels in the placentas of the Hcy-treated group.
Affiliation: Department of Obstetrics and Gynaecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China. Department of Obstetrics and Gynaecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China; Institute of Embryo-Fetal Original Adult Disease Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, PR China. Department of Obstetrics and Gynaecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China. Electronic address: wwcheng29@163.com. .
Related Products: order online
Page 1 2 3 … 7 
Documents per page: 20 | 50 | 100