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49 documents found
1: Title: [The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins].
Authors: Mikurova, A V, et.al. .
Journal: Biomeditsinskaia khimiia (Biomed Khim), Vol. 63 (5): 397-404, 2017 .
Snippet: V rabote provedena otsenka na 5 model'nykh belkakh (CYB5A, SMAD4, RAB27B, FECH i CXXC1) stepeni pokrytiia aminokislotnoĭ posledovatel'nosti v panoramnoĭ proteomike pri ispol'zovanii razlichnykh metodov obrabotki dannykh, vkliuchaiushchikh poiskovye sistemy (Mascot i X!Tandem) i programmy de novo sekvenirovaniia (PEAKS, Novor i PepNovo+).
Affiliation: Institute of Biomedical Chemistry, Moscow, Russia. .
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2: Title: CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.
Authors: Yu, Chao, et.al. .
Journal: Cell reports (Cell Rep), Vol. 20 (5): 1161-1172, 2017 .
Snippet: To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 histone H3K4 methyltransferase, in developing oocytes.
Affiliation: Life Sciences Institute, Zhejiang University, Hangzhou 310058, China; Department of Chemistry and Molecular Biology, Goteborg University, Goteborg SE405 30, Sweden. Biomedical Institute for Pioneering Investigation via Convergence, Peking University, Beijing 100871, China. Life Sciences Institute, Zhejiang University, Hangzhou 310058, China. Institute of Aging Research, Hangzhou Normal University, Hangzhou 311121, China. Institute of Immunology, Zhejiang University Medical School, Hangzhou 310058, China. Department of Chemistry and Molecular Biology, Goteborg University, Goteborg SE405 30, Sweden. Life Sciences Institute, Zhejiang University, Hangzhou 310058, China; Institute of Aging Research, Hangzhou Normal University, Hangzhou 311121, China. Electronic address: hyfan@zju.edu.cn. .
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3: Title: The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.
Authors: Imai, Yukiko, et.al. .
Journal: Chromosoma, 2017 .
Snippet: As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis.
Affiliation: Institut de Génétique Humaine UMR9002 CNRS-Université de Montpellier, 141 rue de la cardonille, 34396, Montpellier cedex 05, France. SEAT-TAAM CNRS Phenomin UPS44, 7 rue Guy Môquet, 94800, Villejuif, France. Faculty of Medicine at the TU Dresden, Institute of Physiological Chemistry, Fetscherstraße 74, 01307, Dresden, Germany. Institut de Génétique Humaine UMR9002 CNRS-Université de Montpellier, 141 rue de la cardonille, 34396, Montpellier cedex 05, France. bernard.de-massy@igh.cnrs.fr. .
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4: Title: PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.
Authors: Parvanov, Emil D, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 28 (3): 488-499, 2017 .
Snippet: By a combination of yeast-two hybrid assay, in vitro binding, and coimmunoprecipitation from mouse spermatocytes, we identified four proteins that directly interact with PRDM9's KRAB domain, namely CXXC1, EWSR1, EHMT2, and CDYL.
Affiliation: Center for Genome Dynamics, Jackson Laboratory, Bar Harbor, ME 04609. Department of Biology, Masaryk University, Brno, Czech Republic 625 00. Department of Biology, Masaryk University, Brno, Czech Republic 625 00 petko.petkov@jax.org lkrejci@chemi.muni.cz. National Centre for Biomolecular Research, Masaryk University, Brno, Czech Republic 625 00. Center for Genome Dynamics, Jackson Laboratory, Bar Harbor, ME 04609 petko.petkov@jax.org lkrejci@chemi.muni.cz. .
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5: Title: Efficient differentiation of murine embryonic stem cells requires the binding of CXXC finger protein 1 to DNA or methylated histone H3-Lys4.
Authors: Mahadevan, Jyothi, et.al. .
Journal: Gene, Vol. 594 (1): 1-9, 2016 .
Snippet: Murine embryonic stem (ES) cells lacking Cfp1 exhibit a loss of histone H3-Lys4 tri-methylation (H3K4me3) at many CpG islands, and a mis-localization of this epigenetic mark to heterochromatic sub-nuclear domains.
Affiliation: Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States; Biology Department, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, United States. Electronic address: dskalnik@iupui.edu. .
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6: Title: Sequences and expression of pathway-specific complement components in developing red-tailed phascogale (Phascogale calura).
Authors: Ong, Oselyne T W, et.al. .
Journal: Developmental and comparative immunology (Dev Comp Immunol), Vol. 65, 2016 .
Snippet: Gene expression of representative molecules from each of the major complement pathways was also investigated in whole body tissues from 1 to 18 day old animals and liver tissues from 31-day to 14-month old animals.
Affiliation: School of Science and Health, Hawkesbury, University of Western Sydney, Locked Bag 1797, Penrith, NSW 2751, Australia. School of Science and Health, Hawkesbury, University of Western Sydney, Locked Bag 1797, Penrith, NSW 2751, Australia. Electronic address: j.old@westernsydney.edu.au. .
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7: Title: CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Authors: Cao, Wenqiang, et.al. .
Journal: Nature communications (Nat Commun), Vol. 7, 2016 .
Snippet: Previous studies have identified Cxxc1 as a regulator of both cytosine methylation and histone 3 lysine 4 trimethylation (H3K4me3).
Affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA. Core Facilities, College of Medicine, Zhejiang University, Hangzhou 310058, China. .
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8: Title: Genes Regulated by Vitamin D in Bone Cells Are Positively Selected in East Asians.
Authors: Arciero, Elena, et.al. .
Journal: PloS one, Vol. 10 (12): e0146072, 2015 .
Snippet: Four of these candidate variants (one each in CXXC1 and RUNX2 and two in LRP5) had a >70% derived allele frequency in East Asians, but were present at lower (20-60%) frequency in Europeans as well, suggesting that the adaptation might have been part of a common response to climatic and dietary changes as humans expanded out of Africa, with implications for their role in vitamin D-dependent bone mineralization and osteoporosis insurgence.
Affiliation: The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, United Kingdom. Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126, Bologna, Italy. Division of Biological Anthropology, University of Cambridge, CB2 1QH, Cambridge, United Kingdom. .
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9: Title: Solution structure of human MBD1 CXXC1.
Authors: Thomson, Ross, et.al. .
Journal: Journal of biomolecular NMR (J Biomol Nmr), Vol. 63 (3): 309-14, 2015 .
No Abstract available.
Affiliation: Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK. Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK. Brian.Smith@glasgow.ac.uk. .
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10: Title: Histone H3K4 trimethylation: dynamic interplay with pre-mRNA splicing.
Authors: Davie, James R, et.al. .
Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire (Biochem Cell Biol), Vol. 94 (1): 1-11, 2016 .
Snippet: CXXC1, which is associated with SETD1A and SETD1B, target these enzymes to unmethylated CpG islands.
Affiliation: Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. .
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11: Title: Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.
Authors: Lauss, Martin, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 135 (7): 1820-8, 2015 .
Snippet: In this study, we obtained genome-wide DNA methylation profiles from 50 stage IV melanomas, normal melanocytes, keratinocytes, and dermal fibroblasts and utilized The Cancer Genome Atlas data for experimental validation.
Affiliation: 1] Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden [2] CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden. Departments of Dermatology and Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA. Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden. 1] Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden [2] Department of Clinical Pathology, Skåne University Hospital, Lund, Sweden. Section of Oncology, Institute of Medicine, University of Bergen, Bergen, Norway. 1] Department of Clinical Molecular Biology and Laboratory Sciences, Akershus University Hospital, Lørenskog, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway. .
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12: Title: The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis.
Authors: Chun, Kristin T, et.al. .
Journal: PloS one, Vol. 9 (12): e113745, 2014 .
Snippet: CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation.
Affiliation: Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Biology Department, Indiana University-Purdue University Indianapolis School of Science, Indianapolis, Indiana, United States of America. Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America. Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America. Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America; Departments of Microbiology & Immunology and Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America. Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America. .
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13: Title: Synthetic CpG islands reveal DNA sequence determinants of chromatin structure.
Authors: Wachter, Elisabeth, et.al. .
Journal: eLife, Vol. 3, 2014 .
Snippet: To determine whether CGI chromatin is developmentally programmed at specific genes or is imposed by shared features of CGI DNA, we integrated artificial CGI-like DNA sequences into the ESC genome.
Affiliation: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom. Genomics and Biotechnology Centre, Technische Universitaet Dresden, Dresden, Germany. .
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14: Title: Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells.
Authors: Clouaire, Thomas, et.al. .
Journal: Genome biology (Genome Biol), Vol. 15 (9): 451, 2014 .
Snippet: We also show that Cfp1-dependent H3K4me3 deposition contributes to H3K9 acetylation genome-wide, suggesting that Cfp1-dependent H3K4me3 regulates overall H3K9 acetylation dynamics and is necessary for histone acetyl transferase recruitment.
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15: Title: Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness.
Authors: Cheray, Mathilde, et.al. .
Journal: Epigenomics, Vol. 6 (3): 267-75, 2014 .
Snippet: AIM: DNA methylation is a fundamental biologic process of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantages.
Affiliation: UMR 892 INSERM, 6299 CNRS, Nantes, France. .
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16: Title: Renal cells exposed to cadmium in vitro and in vivo: normalizing gene expression data.
Authors: Nair, A R, et.al. .
Journal: Journal of applied toxicology : JAT (J Appl Toxicol), Vol. 35 (5): 478-84, 2015 .
Snippet: This study shows that glyceraldehyde-3-phosphate dehydrogenase (Gapdh), tyrosine monooxygenase/tryptophan5-monooxygenase activation-protein, zeta polypeptide (Ywhaz) and beta-actin (Actb) are the most stable reference genes in a kidney proximal tubular cell line exposed to moderate and high Cd concentrations, applied as CdCl2 .
Affiliation: Centre for Environmental Sciences, Hasselt University, Agoralaan Building D, 3590, Diepenbeek, Belgium. .
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17: Title: Extreme HOT regions are CpG-dense promoters in C. elegans and humans.
Authors: Chen, Ron A-J, et.al. .
Journal: Genome research (Genome Res), Vol. 24 (7): 1138-46, 2014 .
Snippet: Nonmethylated CG dinucleotides are recognized by CXXC finger protein 1 (CXXC1, also known as CFP1), which recruits SETD1A (also known as Set1) methyltransferase for trimethylation of histone H3 lysine 4, an active promoter mark.
Affiliation: The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge CB3 0DH, United Kingdom. .
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18: Title: Epigenetics: relevance and implications for public health.
Authors: Rozek, Laura S, et.al. .
Journal: Annual review of public health (Annu Rev Public Health), Vol. 35, 2014 .
Snippet: Chromatin remodeling, histone tail modifications, and DNA methylation are dynamic epigenetic changes responsive to external stimuli.
Affiliation: Department of Environmental Health Sciences, and. .
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19: Title: Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.
Authors: Denissov, Sergei, et.al. .
Journal: Development (Cambridge, England) (Development), Vol. 141 (3): 526-37, 2014 .
Snippet: By contrast, the Set1 complex (Set1C) subunit Cxxc1 is primarily bound to active but not bivalent promoters.
Affiliation: Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences (NCMLS), Radboud University, PO Box 9101, 6500 HB Nijmegen, The Netherlands. .
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20: Title: CpG island chromatin is shaped by recruitment of ZF-CxxC proteins.
Authors: Blackledge, Neil P, et.al. .
Journal: Cold Spring Harbor perspectives in biology (Cold Spring Harbor Perspect Biol), Vol. 5 (11): a018648, 2013 .
Snippet: The action of these zinc finger CxxC domain proteins therefore imposes a defined chromatin architecture on CpG islands that distinguishes these important regulatory elements from the surrounding genome.
Affiliation: Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. .
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