refine search
Cleavage And Polyadenylation Specificity Factor 4
 
Polyadenylation 4
 
mRNA cleavage and polyadenylation specificity factor complex 3
 
mRNA processing 2
 
RNA, Messenger 5
 
Down-Regulation 4
 
Clustered Regularly Interspaced Short Palindromic Repeats 2
 
RNA Precursors 2
 
Endonucleases 2
 
Polymerase Chain Reaction 3
 
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
8 documents found
1: Title: CSR1 suppresses tumor growth and metastasis of human hepatocellular carcinoma via inhibition of HPIP.
Authors: Jiang, L, et.al. .
Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci), Vol. 21 (17): 3813-3820, 2017 .
Snippet: CSR1 has critical roles in the regulation of cell apoptosis via inactivation of CPSF3 or preventing the interaction of XIAP with caspases.
Affiliation: Department of General Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. Liubin3575630@163.com. .
Related Products: order online
2: Title: A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
Authors: Sonoiki, Ebere, et.al. .
Journal: Nature communications (Nat Commun), Vol. 8, 2017 .
Snippet: Multiple P. falciparum lines selected in vitro for resistance to AN3661 harboured point mutations in pfcpsf3, which encodes a homologue of mammalian cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or CPSF3).
Affiliation: Department of Medicine, University of California, Box 0811, San Francisco, California 94143, USA. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, 293 University Hall, 2199 Addison Street, Berkeley, California 94720-7360, USA. Department of Microbiology and Immunology, Columbia University Medical Center, Room 1502 HHSC, 701 West 168th Street, New York, New York 10032, USA. Anacor Pharmaceuticals, Inc., 1020 East Meadow Circle, Palo Alto, California 94303-4230, USA. Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, Box 2542, 1700 4th Street, 403C, San Francisco, California 94158, USA. Malaria Discovery Performance Unit, Diseases of the Developing World, Tres Cantos Medicines Development Campus,GlaxoSmithKline, c/Severo Ochoa 2, Tres Cantos 28760, Spain. Department of Natural Sciences and Mathematics, Dominican University of California, 50 Acacia Avenue, San Rafael, California 94901, USA. Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA. .
Related Products: order online
3: Title: Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.
Authors: Palencia, Andrés, et.al. .
Journal: EMBO molecular medicine (Embo Mol Med), Vol. 9 (3): 385-394, 2017 .
Snippet: Here we report that the benzoxaborole AN3661 had potent in vitro activity against T. gondii Parasites selected to be resistant to AN3661 had mutations in TgCPSF3, which encodes a homologue of cleavage and polyadenylation specificity factor subunit 3 (CPSF-73 or CPSF3), an endonuclease involved in mRNA processing in eukaryotes.
Affiliation: Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions & Immunity to Infection, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France andres.palencia@univ-grenoble-alpes.fr alexandre.bougdour@univ-grenoble-alpes.fr mohamed-ali.hakimi@univ-grenoble-alpes.fr. European Molecular Biology Laboratory (EMBL), Grenoble Outstation and Unit of Virus Host-Cell Interactions, University of Grenoble-EMBL-Centre National de la Recherche Scientifique, Grenoble Cedex 9, France. Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions & Immunity to Infection, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France. Institute for Advanced Biosciences (IAB), OPTIMAL Small Animal Imaging Facility, Grenoble, France. Anacor Pharmaceuticals Inc., Palo Alto, CA, USA. Department of Medicine, University of California, San Francisco, CA, USA. .
Related Products: order online
4: Title: A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression.
Authors: Du, Peng, et.al. .
Journal: Cell, Vol. 162 (4): 885-99, 2015 .
Snippet: The endonuclease CPSF3 (CPSF73) and the spliceosome-associated ISY1 are responsible for pro-miRNA biogenesis and expression of all miRNAs within the cluster except miR-92.
Affiliation: Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA. Electronic address: rgregory@enders.tch.harvard.edu. .
Related Products: order online
5: Title: Comprehensive exploration of novel chimeric transcripts in clear cell renal cell carcinomas using whole transcriptome analysis.
Authors: Gotoh, Masahiro, et.al. .
Journal: Genes, chromosomes & cancer (Genes Chromosomes Cancer), Vol. 53 (12): 1018-32, 2014 .
Snippet: Quantitative RT-PCR analysis revealed that the mRNA expression levels for the MMACHC, PTER, EPC2, ATXN7, FHIT, KIFAP3, CPEB1, MINPP1, TEX264, FAM107A, UPF3A, CDC16, MCCC1, CPSF3, and ASAP2 genes, being partner genes involved in the chimeric transcripts in the initial cohort, were significantly reduced in 26 T samples relative to the corresponding 26 N samples in the second cohort.
Affiliation: Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan. .
Related Products: order online
6: Title: Microarray analysis revealed that immunity-associated genes are primarily regulated by roxarsone in promoting broiler chicken (Gallus gallus domesticus) growth.
Authors: Li, C L, et.al. .
Journal: Poultry science (Poultry Sci), Vol. 91 (12): 3184-90, 2012 .
Snippet: Analysis showed that 30 genes, such as the interleukin 3 regulated nuclear factor (NFIL3), the regulatory factor X-associated ankyrin-containing protein (RFXANK), the cleavage and polyadenylation-specific factor 3 (CPSF3), and the FK506 binding protein 9 (FKBP9), have consistently up or downregulated (fold change ≥1.5 or ≤0.6, P < 0.05, false discovery rate ≤0.05) throughout the medication periods.
Affiliation: Department of Animal Science and Technology, China Agricultural University, Beijing 100094, China. lichanglv@mbg.ae .
Related Products: order online
7: Title: CSR1 induces cell death through inactivation of CPSF3.
Authors: Zhu, Z-H, et.al. .
Journal: Oncogene, Vol. 28 (1): 41-51, 2009 .
Snippet: In this study, we screened a prostate cDNA library using a yeast two-hybrid system and found that the cleavage and polyadenylation-specific factor 3 (CPSF3), an essential component for converting heteronuclear RNA to mRNA, binds with high affinity to the CSR1 C terminus.
Affiliation: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. .
Related Products: order online
8: Title: Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression.
Authors: Calzado, Marco A, et.al. .
Journal: Journal of virology (J Virol), Vol. 78 (13): 6846-54, 2004 .
Snippet: HIV-1 Tat specifically increases the expression of the cleavage and polyadenylation specificity factor (CPSF) 73-kDa subunit (CPSF3) without affecting the expression of the 160- and 100-kDa subunits of the CPSF complex.
Affiliation: Departamento de Biología Celular, Fisiología e Inmunología, Facultad de Medicina, Universidad de Córdoba, Cordoba, Spain. .
Related Products: order online
Documents per page: 20 | 50 | 100