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58 documents found
1: Title: Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis.
Authors: Bhosale, Santosh D, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 8 (1): 9209, 2018 .
Snippet: Fibulin 1 proteoform C (FBLN1C), Beta-ala-his-dipeptidase (CNDP1), Cadherin-13 (CDH13), Gelsolin (GSN) and 72 kDa type IV collagenase (MMP2) were less abundant in cases, whereas Apolipoproteins C-III (APOC3) and apolipoprotein E (APOE) were more abundant.
Affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Faculty of Medicine, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Pharmaceutical Science, University of Maryland, Baltimore, Maryland, USA. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland. rilahes@utu.fi. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. olli.raitakari@utu.fi. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. olli.raitakari@utu.fi. .
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2: Title: Proteomics of liquid biopsies: Depicting RCC infiltration into the renal vein by MS analysis of urine and plasma.
Authors: Chinello, Clizia, et.al. .
Journal: Journal of proteomics (J Proteomics), 2018 .
Snippet: To the augment of vascular involvement, the abundance of only three proteins in urine(UROM,RALA,CNDP1) and two in plasma(APOA1,K2C1) diminished while increased for twenty-six urinary proteins.
Affiliation: Department of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, Vedano al Lambro, Italy. Electronic address: clizia.chinello@unimib.it. Department of Medicine and Surgery, University of Milano-Bicocca, Clinical Proteomics and Metabolomics Unit, Vedano al Lambro, Italy. Pathology Unit, Vimercate Hospital, Vimercate, Italy. Pathology Unit, S.Gerardo Hospital, Monza, Italy. Urology Unit, S.Gerardo Hospital, Monza, Italy. Department of Life Sciences, School of Sciences, European University Cyprus, 1516 Nicosia, Cyprus. .
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3: Title: The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.
Journal: Journal of nutrigenetics and nutrigenomics (J Nutrigenet Nutrigenomics), Vol. 10 (5-6): 146-154, 2018 .
Snippet: We analyzed the relationships between the genotypes of 4 single-nucleotide polymorphisms (SNPs) (rs12605520, rs7244647, rs4891558, and rs17089368) in the CNDP1/CNDP2 locus and body mass index or prevalence of obesity/overweight taking into account dietary carbohydrate and carotene intake.
Affiliation: Laboratory of Human Genetics, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan. .
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4: Title: Ontogeny-related pharmacogene changes in the pediatric liver transcriptome.
Authors: Meier, Richard, et.al. .
Journal: Pharmacogenetics and genomics (Pharmacogenet Genomics), 2018 .
Snippet: The analysis of genome-wide changes detected transcripts in the following genes with significant changes in mRNA expression (P<1×10 with false discovery rate<5×0): ADCY1, PTPRD, CNDP1, DCAF12L1 and HIP1.
Affiliation: Department of Biostatistics, University of Kansas Medical Center. Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation. Division of Experimental and Translational Genetics, Children's Mercy Hospital. Department of Biomedical and Health Informatics, University of Missouri Kansas City School of Medicine, Kansas City, Missouri. Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, USA. .
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5: Title: Carnosinase, diabetes mellitus and the potential relevance of carnosinase deficiency.
Authors: Peters, Verena, et.al. .
Journal: Journal of inherited metabolic disease (J Inherit Metab Dis), Vol. 41 (1): 39-47, 2018 .
Snippet: A CNDP1 polymorphism associated with low CN1 activity correlates with significantly reduced risk for diabetic nephropathy, especially in women with type 2 diabetes, and may slow progression of chronic kidney disease in children with glomerulonephritis.
Affiliation: Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany. Verena.Peters@med.uni-heidelberg.de. Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria. Centre for Paediatric and Adolescent Medicine, University of Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany. .
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6: Title: Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status.
Journal: International journal of sport nutrition and exercise metabolism (Int J Sport Nutr Exerc Metab), 2017 .
Snippet: In conclusion, we found that minor alleles carriers for CNDP2 rs3764509 (G-allele), CNDP2-CNDP1 rs2346061 (C-allele) and CNDP1 rs2887 (A-allele) are more likely to be a power athlete.
Affiliation: 1 School of Physical Education and Sport, University of São Paulo, Sao Paulo, SP, Brazil. .
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7: Title: Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.
Authors: Peters, Verena, et.al. .
Journal: Journal of enzyme inhibition and medicinal chemistry (J Enzyme Inhib Med Chem), Vol. 32 (1): 1102-1110, 2017 .
Snippet: In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy.
Affiliation: a Centre for Paediatric and Adolescent Medicine , University of Heidelberg , Heidelberg , Germany. b Department of Biomedical and Biotechnological Sciences, School of Medicine , University of Catania , Catania , Italy. c Department of Internal Medicine , University Heidelberg , Heidelberg , Germany. d The Rolf Luft Center Research Center for Diabetes and Endocrinology , Karolinska Institutet , Stockholm , Sweden. e Institute for Physiology and Pathophysiology, University Heidelberg , Heidelberg , Germany. f Department of Pharmaceutical Sciences , Università degli Studi di Milano , Milan , Italy. .
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8: Title: The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration.
Authors: Albrecht, Thomas, et.al. .
Journal: Journal of diabetes research (J Diabetes Res), Vol. 2017, 2017 .
Snippet: Considering that the homozygous CNDP1 (CTG)5 genotype affords protection against diabetic nephropathy (DN) in female patients with type 2 diabetes, this study assessed if this association remains gender-specific when applying clinical inclusion criteria (CIC-DN) or biopsy proof (BP-DN).
Affiliation: Fifth Medical Department (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Centre for Pediatric and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany. Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. .
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9: Title: Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice.
Authors: Albrecht, Thomas, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients.
Affiliation: Department of Nephrology, Endocrinology and Rheumatology, Fifth Department of Medicine, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany. The Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands. The Department of Pharmaceutical Sciences, University of Milan, Milan, Italy. Department of Nephrology, University Medical Center Groningen, Groningen, the Netherlands. .
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10: Title: Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians.
Authors: Yadav, Ashok K, et.al. .
Journal: The Indian journal of medical research (Indian J Med Res), Vol. 144 (1): 32-37, 2016 .
Snippet: INTERPRETATION & CONCLUSIONS: Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population.
Affiliation: Department of Nephrology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. Department of Endocrinology, Post Graduate Institute of Medical Education & Research, Chandigarh, India. Department of Nephrology, Post Graduate Institute of Medical Education & Research, Chandigarh; George Institute for Global Health, New Delhi, India. .
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11: Title: The (CTG)n repeat polymorphism in CNDP1 gene: New insights into an old molecule.
Journal: The Indian journal of medical research (Indian J Med Res), Vol. 144 (1): 6-8, 2016 .
No Abstract available.
Affiliation: Laboratory of Human Molecular Genetics, Lutheran University of Brazil (ULBRA) Canoas, RS, Brazil. .
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12: Title: CNDP1 genotype and renal survival in pediatric nephropathies.
Authors: Peters, Verena, et.al. .
Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab), Vol. 29 (7): 827-33, 2016 .
Snippet: METHODS: To evaluate the impact of the CNDP1 Mannheim allele on pediatric chronic kidney disease (CKD), we prospectively followed the long-term clinical outcome of 272 children with non-diabetic kidney disease (glomerulopathies n=32, non-glomerular kidney disease n=240).
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13: Title: Carnosine and Homocarnosine Degradation Mechanisms by the Human Carnosinase Enzyme CN1: Insights from Multiscale Simulations.
Authors: Pavlin, Matic, et.al. .
Journal: Biochemistry, Vol. 55 (19): 2772-84, 2016 .
Snippet: (iii) Hydrogen bonds at the binding site, present in the dimer but absent in the monomer, might play a role in the experimentally observed higher activity of the dimeric form.
Affiliation: Laboratory for Computational Biophysics, German Research School for Simulation Sciences (GRS), Forschungszentrum Jülich-RWTH Aachen , 52425 Jülich, Germany. Computational Biomedicine Section (INM-9), Institute for Neuroscience and Medicine (INM), and Institute of Advanced Simulation (IAS), Forschungszentrum Jülich , 52425 Jülich, Germany. Jülich Supercomputing Center (JSC), Forschungszentrum Jülich , 52425 Jülich, Germany. Department of Oncology, Hematology and Stem Cell Transplantation, University Hospital Aachen, RWTH Aachen University , Pauwelsstraße 30, 52074 Aachen, Germany. Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia , Via Morego 30, 16163 Genoa, Italy. .
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14: Title: Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.
Authors: Zhang, Shiqi, et.al. .
Journal: PloS one, Vol. 11 (1): e0146831, 2016 .
Snippet: Since patients with kidney failure are often deficient in zinc and other trace elements we also assessed the RYSK173 CN-1 proportion in serum of these patients and studied the influence of hemodialysis hereon in relation to Zn2+ and Cu2+ concentration during hemodialysis.
Affiliation: Vth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Department of Endocrinology, The first affiliated hospital of Anhui Medical University, Hefei, China. Department of Anesthesiology and Surgical Intensive Care Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany. Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. .
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15: Title: Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine.
Authors: Zhang, Shiqi, et.al. .
Journal: Journal of diabetes research (J Diabetes Res), Vol. 2016, 2016 .
Snippet: HG did not change the expression of divalent metal transporter 1 (DMT1), ferroportin (IREG), and transferrin receptor protein 1 (TFRC).
Affiliation: Vth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, 68167 Mannheim, Germany; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Vth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, 68167 Mannheim, Germany; Department of Cardiology, Pulmonology, Intensive Care and Vascular Medicine, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany. Vth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, 68167 Mannheim, Germany. Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, Netherlands. .
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16: Title: Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes.
Authors: Stegen, Sanne, et.al. .
Journal: American journal of physiology. Endocrinology and metabolism (Am J Physiol Endocrinol Metab), Vol. 309 (7): E663-9, 2015 .
Snippet: A particular allele of the carnosinase gene (CNDP1) is associated with reduced plasma carnosinase activity and reduced risk for nephropathy in diabetic patients.
Affiliation: Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium; Departments of Medicine, Cardiac Sciences, and Community Health Sciences, Cumming School of Medicine, Faculties of Medicine and Kinesiology, University of Calgary, Calgary, Alberta, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Alberta Health Services, Calgary, Alberta, Canada; 5th Medical Department, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; and. Department of Family Medicine and Primary Health Care, Ghent University, Ghent, Belgium. Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium; wim.derave@ugent.be. .
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17: Title: Intrinsic carnosine metabolism in the human kidney.
Authors: Peters, Verena, et.al. .
Journal: Amino acids, Vol. 47 (12): 2541-50, 2015 .
Snippet: Expression, distribution, and localization of carnosinase-1 (CNDP1), carnosine synthase (CARNS), and taurine transporters (TauT) were measured in human kidneys.
Affiliation: University Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg, Germany. Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. c.q.f.klessens@lumc.nl. Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. Department of Metabolic Regulation, Faculty of Biology, University of Warsaw, Krakowskie Przedmieście 26/28, 00-927, Warsaw, Poland. Department of Human Genetics, Medical University of Innsbruck, Innrain 52, Christoph-Probst-Platz, 6020, Innsbruck, Austria. .
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18: Title: Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Authors: Arner, Peter, et.al. .
Journal: PloS one, Vol. 10 (4): e0123566, 2015 .
Snippet: These results, together with recently published data demonstrating lower circulating CNDP1 in subjects with glioblastoma and metastatic prostate cancer, suggest that CNDP1 may constitute a marker of aggressive cancer and CC.
Affiliation: Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden. Affinity Proteomics, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Box 1031, 171 21, Solna, Sweden. Department of Surgery, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden. Division of Surgery, Department for Clinical Science, Intervention and Technology (CLINTEC), Södersjukhuset, 118 83, Stockholm, Sweden. .
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19: Title: Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase.
Authors: Veiga-da-Cunha, Maria, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 289 (28): 19726-36, 2014 .
Snippet: Carnosine synthase is the ATP-dependent ligase responsible for carnosine (β-alanyl-histidine) and homocarnosine (γ-aminobutyryl-histidine) synthesis in skeletal muscle and brain, respectively.
Affiliation: From the Welbio and the Laboratory of Physiological Chemistry, maria.veiga@uclouvain.be. From the Welbio and the Laboratory of Physiological Chemistry. the Ludwig Institute for Cancer Research, and. the Protein Phosphorylation Unit, de Duve Institute, Université Catholique de Louvain, 1200 Brussels, Belgium. .
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20: Title: Sex specific association between carnosinase gene CNDP1 and cardiovascular mortality in patients with type 2 diabetes (ZODIAC-22).
Authors: Alkhalaf, A, et.al. .
Journal: Journal of nephrology (J Nephrol), Vol. 28 (2): 201-7, 2015 .
Snippet: INTRODUCTION: Homozygosity for a 5-leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been associated with a reduced prevalence of diabetic nephropathy in cross-sectional studies in patients with type 2 diabetes, particularly in women.
Affiliation: Diabetes Centre, Isala Clinics, Dr. Spanjaardweg 11, P.O. Box 10400, 8000 GK, Zwolle, The Netherlands. .
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