refine search
Chloride Channels 13
 
chloride channel complex 9
 
Chlorides 12
 
Niflumic Acid 3
 
Oligonucleotide Array Sequence Analysis 5
 
gene expression 7
 
Up-Regulation 6
 
RNA, Messenger 7
 
Cystic Fibrosis 4
 
Genomics 6
 
Authors
Locations
Journals
Publication Dates
Find concepts in Knowledge Base
Explore current query
documentsstatisticstop authorclipboard
20 documents found
1: Title: CLCA4 inhibits bladder cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT pathway.
Authors: Hou, Teng, et.al. .
Journal: Oncotarget, Vol. 8 (54): 93001-93013, 2017 .
Snippet: Additionally, CLCA4 could mediate the migration and invasion of bladder cancer cells by regulating epithelial-mesenchymal transition and PI3K/Akt activation.
Affiliation: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Department of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China. .
Related Products: order online
2: Title: DNA methylation patterns and gene expression associated with litter size in Berkshire pig placenta.
Authors: Hwang, Jung Hye, et.al. .
Journal: PloS one, Vol. 12 (9): e0184539, 2017 .
Snippet: The expression of only three of these genes (PRKG2, CLCA4, and PCK1) was verified by RT-qPCR.
Affiliation: Swine Science and Technology Center, Gyeongnam National University of Science & Technology, Jinju, South Korea. Department of Animal Resource Technology, Gyeongnam National University of Science & Technology, Jinju, South Korea. Dasan Pig Breeding Co., Namwon, South Korea. .
Related Products: order online
3: Title: A global analysis of CNVs in swine using whole genome sequence data and association analysis with fatty acid composition and growth traits.
Authors: Revilla, Manuel, et.al. .
Journal: PloS one, Vol. 12 (5): e0177014, 2017 .
Snippet: Some of the identified CNVRs contained relevant functional genes (e.g., CLCA4, CYP4X1, GPAT2, MOGAT2, PLA2G2A and PRKG1, among others).
Affiliation: Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. Plant and Animal Genomics, Centre de Recerca en Agrigenòmica (CRAG), Consorci CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Spain. Department of Animal Science, Santa Catarina State University, Lages, Santa Catarina, Brazil. Departamento de Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain. Departament de Genètica i Millora Animal, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui, Spain. .
Related Products: order online
4: Title: Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy.
Authors: Long, Hong-Yu, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 7, 2017 .
Snippet: The differentially methylated genes were largely related to pathways predicted to participate in anion binding, oxidoreductant activity, growth regulation, skeletal development and drug metabolism, with the most distinct ones included SLC34A2, CLCN6, CLCA4, CYP3A43, CYP3A4 and CYP2C9.
Affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Department of Anatomy and Neurobiology, Central South University School of Basic Medicine, Changsha, Hunan 410013, China. Key Laboratory of Hunan Province in Neurodegenerative Disorders, Changsha, Hunan 410008, China. .
Related Products: order online
5: Title: Naturally Occurring Deletion Mutants of the Pig-Specific, Intestinal Crypt Epithelial Cell Protein CLCA4b without Apparent Phenotype.
Authors: Plog, Stephanie, et.al. .
Journal: PloS one, Vol. 10 (10): e0140050, 2015 .
Snippet: The CLCA4b gene is a pig-specific duplication product of the CLCA4 ancestor and its protein is exclusively expressed in small and large intestinal crypt epithelial cells, a niche specifically occupied by no other porcine CLCA family member.
Affiliation: Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany. Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität, Munich, Oberschleissheim, Germany. Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America. .
Related Products: order online
6: Title: Uterine Contractility in the Nonpregnant Mouse: Changes During the Estrous Cycle and Effects of Chloride Channel Blockade.
Authors: Dodds, Kelsi N, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 92 (6): 141, 2015 .
Snippet: It is unlikely that this conductance is generated by the Ca(2+)-activated Cl(-) channels, anoctamin-1 and CLCA4, as immunohistochemical labeling did not reveal protein expression within muscle or pacemaker cell networks.
Affiliation: Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia. Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia elizabeth.beckett@adelaide.edu.au. .
Related Products: order online
7: Title: Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70.
Authors: Bundela, Saurabh, et.al. .
Journal: PloS one, Vol. 9 (7): e102610, 2014 .
Snippet: In all, 2365 genes were detected to be differentially expressed genes, which includes some of the highly differentially expressed genes like matrix metalloproteinases (MMP-1/3/10/13), chemokine (C-X-C motif) ligands (IL8, CXCL-10/-11), PTHLH, SERPINE1, NELL2, S100A7A, MAL, CRNN, TGM3, CLCA4, keratins (KRT-3/4/13/76/78), SERPINB11 and serine peptidase inhibitors (SPINK-5/7).
Affiliation: Defence Research Development Establishment, Defence Research Development Organization, Ministry of Defence, Govt. of India, Gwalior, Madhya Pradesh, India; Department of Postgraduate Studies & Research in Biological Sciences, Rani Durgavati University, Jabalpur, Madhya Pradesh, India. Department of Postgraduate Studies & Research in Biological Sciences, Rani Durgavati University, Jabalpur, Madhya Pradesh, India. Defence Research Development Establishment, Defence Research Development Organization, Ministry of Defence, Govt. of India, Gwalior, Madhya Pradesh, India; School of Studies in Biotechnology, Jiwaji University, Gwalior, Madhya Pradesh, India. .
Related Products: order online
8: Title: Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells.
Authors: Yu, Yang, et.al. .
Journal: PloS one, Vol. 8 (12): e83943, 2013 .
Snippet: We show here that another member of the CLCA gene family, CLCA4, is expressed in mammary epithelial cells and is similarly downregulated in breast tumors and in breast cancer cell lines.
Affiliation: Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America. Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America ; Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America ; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America. Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America ; Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America. .
Related Products: order online
9: Title: The transition from proliferation to differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1.
Authors: Yang, Bo, et.al. .
Journal: PloS one, Vol. 8 (4): e60861, 2013 .
Snippet: We showed that: 1) CLCA1 and CLCA4 expression were down-regulated significantly in CRC patients; 2) CLCA1 expression was up-regulated in Caco-2 cells induced to differentiate by confluent culture or by treatment with sodium butyrate (NaBT); 3) Knockdown of CLCA1 with siRNA significantly inhibited cell differentiation and promoted cell proliferation in Caco-2 confluent cultures, and 4) In Caco-2 3D culture, suppression of CLCA1 significantly increased cell proliferation and compromised NaBT-induced inhibition of proliferation.
Affiliation: Department of General Surgery, The 309th Hospital of PLA, Beijing, China. y7115@sina.com .
Related Products: order online
10: Title: Single nucleotide polymorphism array analysis in men with idiopathic azoospermia or oligoasthenozoospermia syndrome.
Authors: Frühmesser, Anne, et.al. .
Journal: Fertility and sterility (Fertil Steril), Vol. 100 (1): 81-7, 2013 .
Snippet: We therefore conclude that CLCA4 might be functional during human spermatogenesis after meiosis, most likely as a modifier of CFTR gene expression.
Affiliation: Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Human Genetics, Innsbruck Medical University, Innsbruck, Austria. .
Related Products: order online
11: Title: CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine.
Authors: Kolbe, Ernst-Wolfgang, et.al. .
Journal: European journal of human genetics : EJHG (Eur J Hum Genet), Vol. 21 (6): 691-4, 2013 .
Snippet: Refined analysis of the CLCA4 association signal among F508del homozygous CF patients who exhibit either no, CFTR-mediated or Ca(2+)-mediated residual chloride conductance revealed that allele distributions for markers rs11807298-rs113894048-rs6684219 differed significantly among these three patient groups.
Affiliation: Department of Pediatrics, Hannover Medical School, Hannover, Germany. .
Related Products: order online
12: Title: The porcine chloride channel calcium-activated family member pCLCA4a mirrors lung expression of the human hCLCA4.
Authors: Plog, Stephanie, et.al. .
Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (J Histochem Cytochem), Vol. 60 (1): 45-56, 2012 .
Snippet: The human CLCA (originally named chloride channels, calcium-activated) member hCLCA4 is considered a potential modifier of disease severity in CF, but its murine ortholog, mCLCA6, is not expressed in the mouse lung.
Affiliation: Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany. .
Related Products: order online
13: Title: Inward-rectifier chloride currents in Reissner's membrane epithelial cells.
Authors: Kim, Kyunghee X, et.al. .
Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), Vol. 394 (2): 434-8, 2010 .
Snippet: Channel transcripts expressed include ClC-2, Slc26a7 and ClC-Ka, but not Cftr, ClC-1, ClCa1, ClCa2, ClCa3, ClCa4, Slc26a9, ClC-Kb, Best1, Best2, Best3 or the beta-subunit of ClC-K, barttin.
Affiliation: Cellular Biophysics Laboratory, Kansas State University, Dept. of Anatomy and Physiology, 228 Coles Hall, Manhattan, KS 66506-5802, USA. .
Related Products: order online
14: Title: Biomarkers of human gastrointestinal tract regions.
Authors: Comelli, Elena Maria, et.al. .
Journal: Mammalian genome : official journal of the International Mammalian Genome Society (Mamm Genome), Vol. 20 (8): 516-27, 2009 .
Snippet: These include CLCA4 and SLC26A2, both implicated in ion transport.
Affiliation: Department of Nutrition and Health, Nestlé Research Center, Vers chez les Blanc, Lausanne, Switzerland. elena.comelli@utoronto.ca .
Related Products: order online
15: Title: Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.
Authors: Piirsoo, Marko, et.al. .
Journal: BMC developmental biology (Bmc Dev Biol), Vol. 9, 2009 .
Snippet: While human CLCA2 and CLCA4 genes are widely expressed in brain, and at particularly high levels in the optic nerve, human CLCA3, the closest homologue of mouse Clca1, Clca2 and Clca4, is not expressed in the brain.
Affiliation: Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia. marko.piirsoo@ttu.ee .
Related Products: order online
16: Title: Cloning and characterization of a calcium-activated chloride channel in rat uterus.
Authors: Song, Junfang, et.al. .
Journal: Biology of reproduction (Biol Reprod), Vol. 80 (4): 788-94, 2009 .
Snippet: Transient transfection of rat CLCA4-enhanced green fluorescent protein in Chinese hamster ovary cells resulted in production of characteristic Cl(-) currents that could be activated by Ca(2+) and ionomycin but inhibited by niflumic acid, a CLCA-channel blocker.
Affiliation: Institute of Genetics and Developmental Biology and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. .
Related Products: order online
17: Title: mCLCA4 ER processing and secretion requires luminal sorting motifs.
Authors: Huan, Chunlei, et.al. .
Journal: American journal of physiology. Cell physiology (Am J Physiol-cell Ph), Vol. 295 (1): C279-87, 2008 .
Snippet: The 125-kDa mCLCA4 gene product is cleaved to 90- and 40-kDa fragments, and the NH(2)- and COOH-terminal fragments are secreted, where they are found in cell media and associated with the plasma membrane.
Affiliation: Biomedical Sciences Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA. .
Related Products: order online
18: Title: Transcriptomic dissection of tongue squamous cell carcinoma.
Authors: Ye, Hui, et.al. .
Journal: BMC genomics, Vol. 9, 2008 .
Snippet: These include up-regulated genes (MMP1, MMP10, MMP3, MMP12, PTHLH, INHBA, LAMC2, IL8, KRT17, COL1A2, IFI6, ISG15, PLAU, GREM1, MMP9, IFI44, CXCL1), and down-regulated genes (KRT4, MAL, CRNN, SCEL, CRISP3, SPINK5, CLCA4, ADH1B, P11, TGM3, RHCG, PPP1R3C, CEACAM7, HPGD, CFD, ABCA8, CLU, CYP3A5).
Affiliation: Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA. huiye@uic.edu .
Related Products: order online
19: Title: Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.
Authors: Huang, Liquan, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 280 (43): 36150-7, 2005 .
Snippet: The chloride channel blockers niflumic acid and 5-nitro-2-(3-phenylpropylamino)benzoic acid had a slight or no inhibitory effect on the conductance of ClC-4, but both blockers inhibited ClC-4A, suggesting that ClC-4A is a candidate channel for an acid-induced 5-nitro-2-(3-phenylpropylamino)benzoic acid-sensitive current.
Affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308, USA. lhuang@monell.org .
Related Products: order online
20: Title: The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.
Authors: Ritzka, Margit, et.al. .
Journal: Human genetics (Hum Genet), Vol. 115 (6): 483-91, 2004 .
Snippet: Expression of hCLCA1 and hCLCA4 in human rectal mucosa was proven by microarray analysis.
Affiliation: Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl-Neuberg Str. 1, 30625 Hannover, Germany. .
Related Products: order online
Documents per page: 20 | 50 | 100