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184 documents found
1: Title: Disease-related autoantibody profile in patients with systemic sclerosis.
Authors: Liaskos, Christos, et.al. .
Journal: Autoimmunity, 2017 .
Snippet: SSc patients were positive for at least one autoAb: anti-Topoisomerase I (anti-Topo) I abs in 54 (41.2%), anti-centromere proteins (anti-CENP) in 37 (28.2%, all reactive with centromere protein-A (CENPA) and centromere protein B (CENPB)), anti-RNA polymerase III(RP11) in 19 (14.5%), anti-RNA polymerase III(RP155) in 13 (9.9%),
Affiliation: a Department of Rheumatology and Clinical Immunology , Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa , Greece. b Biomedical Section , Institute of Research and Technology Thessaly, Centre for Research and Technology Hellas (CERTH) , Larissa , Greece. c Institute of Immunology affiliated to Euroimmun AG , Lübeck , Germany. d Division of Transplantation, Immunology and Mucosal Biology , MRC Centre for Transplantation, King's College London Medical School , London , UK. e Center for Molecular Medicine , Old Dominion University , Norfolk , VA , USA. .
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2: Title: Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML.
Authors: Dixon, Charles R, et.al. .
Journal: Cells (Unknown Journal), Vol. 6 (2), 2017 .
Snippet: HP1, CenpB and PML proteins accumulated at these structures for both constructs, indicating that other sites supporting chromatin interactions exist on lamin A. Together, these results indicate that lamin A-chromatin interactions are highly redundant and more diverse than generally acknowledged and highlight the importance of trying to experimentally separate their individual functions.
Affiliation: The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Swann 5.22, Max Born Crescent, Edinburgh EH9 3BF, UK. s1581423@sms.ed.ac.uk. The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Swann 5.22, Max Born Crescent, Edinburgh EH9 3BF, UK. m.platani@ed.ac.uk. The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Swann 5.22, Max Born Crescent, Edinburgh EH9 3BF, UK. amcarov@gmail.com. The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Kings Buildings, Swann 5.22, Max Born Crescent, Edinburgh EH9 3BF, UK. e.schirmer@ed.ac.uk. .
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3: Title: Mutational spectrum of CENP-B box and α-satellite DNA on chromosome 21 in Down syndrome children.
Authors: Chen, Qian, et.al. .
Journal: Molecular medicine reports (Mol Med Report), Vol. 15 (4): 2313-2317, 2017 .
Snippet: Centromere protein B (CENP‑B) and its 17 base pair binding site (CENP‑B box), which appears at regular intervals in centromeric α-satellite DNA (α-satDNA), are important for the assembly of the centromere components.
Affiliation: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China. Pediatrics Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, P.R. China. Laboratory of Reproductive Biology, Public Health College, Chongqing Medical University, Chongqing 400016, P.R. China. .
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4: Title: Increased immunoreactivity against human cytomegalovirus UL83 in systemic sclerosis.
Authors: Marou, Emmanouela, et.al. .
Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol), 2017 .
Snippet: Reactivity to UL83 HCMV was assessed in relation to clinical manifestations and SSc-related autoantibodies (autoAbs), tested by an IgG SSc autoantibody profile line immunoassay (Euroimmun) that detects autoAbs against Scl-70, CENPA, CENPB, RNA polymerase III subunit 11 (RP11), RP155, fibrillarin, NOR90, Th/To, PM-Scl100, PM-Scl75, Ku, PDGFR and Ro-52.
Affiliation: Dept. Rheumatology & Clin. Immunol., School Health Sciences, Univ.of Thessaly, Larissa; and Cellular Immunotherapy & Molecular Immunodiagnostics, Biomedical Section, Ctre for Res. & Technology-Hellas (CERTH)- Inst. Research & Technology-Thessaly, Greece. Department of Neurology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. Department of Gynaecology and Obstetrics, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. Institute of Immunology, Euroimmun, Lübeck, Germany. Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. lsakkas@med.uth.gr. .
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5: Title: Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.
Authors: Upadhyay, Udita, et.al. .
Journal: Molecular biology of the cell (Mol Biol Cell), Vol. 28 (8): 1132-1146, 2017 .
Snippet: We find that whereas the Ago1 subunit of the RITS complex is highly conserved, Tas3 is lost and Chp1 is truncated in Schizosaccharomyces cryophilus and Schizosaccharomyces octosporus We show that truncated Chp1 loses the property of heterochromatin localization and silencing when transformed in Schizosaccharomyces pombe Furthermore, multiple copies of CENPB, related to Tc1/mariner and Tc5 transposons, occur in all Schizosaccharomyces species, as well as in humans, but with loss of transposase function (except Schizosaccharomyces japonicus).
Affiliation: Department of Anesthesiology, Miller School of Medicine, University of Miami, Miami, FL 33136. Yeast Epigenetic Regulation Laboratory, Council of Scientific and Industrial Research, Chandigarh 160036, India. Department of Medicine and Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215. Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106. Protein Evolution Laboratory, Council of Scientific and Industrial Research, Chandigarh 160036, India. Microbial Type Culture Collection, Institute of Microbial Technology, Council of Scientific and Industrial Research, Chandigarh 160036, India. Yeast Epigenetic Regulation Laboratory, Council of Scientific and Industrial Research, Chandigarh 160036, India jag@imtech.res.in. .
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6: Title: Clinical autoantibody detection by microarray.
Authors: Dillaerts, Doreen, et.al. .
Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med), Vol. 55 (4): 578-585, 2017 .
Snippet: The results obtained by AMiDot on the clinical samples were compared to results obtained by EliA (Thermo Fisher) for anti-Ro60, anti-La, anti-RNP, anti-Scl-70, anti-CENPB, anti-Sm, and anti-Jo-1 and by Farr assay for anti-dsDNA.
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7: Title: CENPT bridges adjacent CENPA nucleosomes on young human α-satellite dimers.
Authors: Thakur, Jitendra, et.al. .
Journal: Genome research (Genome Res), Vol. 26 (9): 1178-87, 2016 .
Snippet: In contrast to the currently accepted model in which CENPT associates with H3 nucleosomes, we find that CENPT is centered over the CENPB box between two well-positioned CENPA nucleosomes on the most abundant centromeric young α-satellite dimers and interacts with the CENPB/CENPC complex.
Affiliation: Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. .
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8: Title: Enrichment of Scleroderma Vascular Disease-Associated Autoantigens in Endothelial Lineage Cells.
Authors: McMahan, Zsuzsanna H, et.al. .
Journal: Arthritis & rheumatology (Hoboken, N.J.) (Arthritis Rheumatol), Vol. 68 (10): 2540-9, 2016 .
Snippet: Immunohistochemical staining of paraffin-embedded skin sections showed enrichment of IFI-16 in CD31-positive vascular endothelial cells in biopsy specimens from scleroderma patients and normal controls.
Affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland. Johns Hopkins University School of Medicine, Baltimore, Maryland. lcr@jhmi.edu. .
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9: Title: Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity.
Authors: Slight-Webb, Samantha, et.al. .
Journal: Arthritis & rheumatology (Hoboken, N.J.) (Arthritis Rheumatol), Vol. 68 (10): 2492-502, 2016 .
Snippet: The majority of proinflammatory cytokines, including interferon-γ (IFNγ), tumor necrosis factor, interleukin-17 (IL-17), and granulocyte colony-stimulating factor, exhibited a stepwise increase in serum levels from ANA-negative controls to ANA-positive healthy individuals to SLE patients (P < 0.0001).
Affiliation: Oklahoma Medical Research Foundation, Oklahoma City. Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City. Stanford University School of Medicine, Stanford, California. Oklahoma Medical Research Foundation, and University of Oklahoma Health Sciences Center, Oklahoma City. Judith-James@omrf.org. .
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10: Title: Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis.
Authors: Patterson, K A, et.al. .
Journal: Arthritis & rheumatology (Hoboken, N.J.) (Arthritis Rheumatol), Vol. 67 (12): 3234-44, 2015 .
Snippet: METHODS: Serum from 505 Australian SSc patients were analyzed with a commercial line immunoassay (EuroLine; Euroimmun) for autoantibodies to centromere proteins CENP-A and CENP-B, RNA polymerase III (RNAP III; epitopes 11 and 155), the 90-kd nucleolar protein NOR-90, fibrillarin, Th/To, PM/Scl-75, PM/Scl-100, Ku, topoisomerase I (topo I), tripartite motif-containing protein 21/Ro 52, and platelet-derived growth factor receptor.
Affiliation: Flinders University, Bedford Park, South Australia, and Commonwealth Scientific and Industrial Research Organization (CSIRO), Adelaide, South Australia, Australia. Flinders University and Flinders Medical Centre, Bedford Park, South Australia, and SA Pathology, Adelaide, South Australia, Australia. Queen Elizabeth Hospital, Woodville, South Australia, Australia. Flinders Medical Centre, Bedford Park, South Australia, Australia. University of Adelaide, Adelaide, South Australia, and Queen Elizabeth Hospital, Woodville, South Australia, Australia. Menzies Institute for Medical Research, Hobart, Tasmania, Australia. Monash Health and Monash University, Melbourne, Victoria, Australia. University of Queensland, Brisbane, Queensland, Australia. Royal Perth Hospital, Perth, Western Australia, Australia. University of Melbourne and St. Vincent's Hospital Melbourne, Melbourne, Victoria, Australia. St. Vincent's Hospital, Melbourne, Victoria, Australia. University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia. Flinders University and Flinders Medical Centre, Bedford Park, South Australia, and Repatriation General Hospital, Daw Park, South Australia, Australia. .
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11: Title: DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.
Authors: Fachinetti, Daniele, et.al. .
Journal: Developmental cell (Dev Cell), Vol. 33 (3): 314-27, 2015 .
Snippet: Human centromeres are specified by a stably inherited epigenetic mark that maintains centromere position and function through a two-step mechanism relying on self-templating centromeric chromatin assembled with the histone H3 variant CENP-A, followed by CENP-A-dependent nucleation of kinetochore assembly.
Affiliation: Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: dfachinetti@ucsd.edu. Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: dcleveland@ucsd.edu. .
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12: Title: HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B.
Authors: Mukai, Risa, et.al. .
Journal: The Journal of general virology (J Gen Virol), Vol. 96 (Pt 1): 159-64, 2015 .
Snippet: Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells.
Affiliation: Graduate School of Engineering, Tokushima Bunri University, Sanuki, Kagawa, Japan. Graduate School of Engineering, Tokushima Bunri University, Sanuki, Kagawa, Japan Faculty of Pharmaceutical Science at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, Japan ohshimat@kph.bunri-u.ac.jp. .
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13: Title: Relating centromeric topography in fixed human chromosomes to α-satellite DNA and CENP-B distribution.
Authors: Khan, W A, et.al. .
Journal: Cytogenetic and genome research (Cytogenet Genome Res), Vol. 139 (4): 234-42, 2013 .
Snippet: We have developed a method with correlative fluorescence light microscopy and atomic force microscopy that investigates the physical and structural organization of α-satellite DNA sequences in the context of its associated protein, CENP-B, on human metaphase chromosome topography.
Affiliation: Department of Pathology, Schulich School of Medicine and Dentistry, London, Ont, Canada. .
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14: Title: HACking the centromere chromatin code: insights from human artificial chromosomes.
Authors: Bergmann, Jan H, et.al. .
Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology (Chromosome Res), Vol. 20 (5): 505-19, 2012 .
Snippet: At the centromere, CENP-A nucleosomes form part of a chromatin landscape termed centrochromatin.
Affiliation: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. jbergmann@cshl.edu .
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15: Title: Fluoroenzymeimmunoassay to detect systemic sclerosis-associated antibodies: diagnostic performance and correlation with conventional techniques.
Authors: Bonroy, Carolien, et.al. .
Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol), Vol. 30 (5): 748-55, 2012 Sep-Oct .
Snippet: METHODS: Sera from 144 consecutive systemic sclerosis (SSc) patients previously tested by CCT (indirect immunofluorescence on HEp-2000, western blotting, protein radio immunoprecipitation and a well-documented line immunoassay) and an additional group of 266 disease controls (80 rheumatoid arthritis, 58 systemic lupus erythematosus, 50 spondyloarthropathy, 48 osteoarthritis, 18 polymyalgia rheumatica and 12 ANCA-associated vasculitis) were retrospectively evaluated.
Affiliation: Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium. carolien.bonroy@uzgent.be .
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16: Title: Evaluation of a new multi-parallel line immunoassay for systemic sclerosis-associated antibodies in an Asian population.
Authors: Low, Andrea H L, et.al. .
Journal: Rheumatology (Oxford, England) (Rheumatology (oxford)), Vol. 51 (8): 1465-70, 2012 .
Snippet: Anti-CENPB was associated with joint pain [odds ratio (OR) 0.17], interstitial lung disease (OR 0.24) and telangiectasia (OR 4.00) (P < 0.05).
Affiliation: Block 6 Level 9, Department of Rheumatology and Immunology, Singapore General Hospital, Outram Road, Singapore 169608. andrea.low.h.l@sgh.com.sg .
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17: Title: Clinical correlates of CENP-A and CENP-B antibodies in a large cohort of patients with systemic sclerosis.
Authors: Hudson, Marie, et.al. .
Journal: The Journal of rheumatology (J Rheumatol), Vol. 39 (4): 787-94, 2012 .
Snippet: Patients having ACA, CENP-A, and/or CENP-B resembled each other and differed from the remainder of the cohort in the following respects: older chronologically and at disease onset; more commonly women; more likely to have limited disease and lower skin scores; less likely to have finger ulcers, digital tuft resorption, or finger contractures; more likely to have pulmonary hypertension; less likely to have interstitial lung disease, scleroderma renal crisis, inflammatory arthritis, and inflammatory myositis; and having lower overall disease severity.
Affiliation: Jewish General Hospital, Room A-725, 3755 Cote Ste Catherine Road, Montreal, Quebec H3T 1E2, Canada. marie.hudson@mcgill.ca .
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18: Title: Stable integration of an engineered megabase repeat array into the maize genome.
Authors: Zhang, Han, et.al. .
Journal: The Plant journal : for cell and molecular biology (Plant J), Vol. 70 (2): 357-65, 2012 .
Snippet: We designed a synthetic repeat monomer of 156 bp that contains five DNA-binding motifs (LacO, TetO, Gal4, LexA, and CENPB), and extended it into tandem arrays using an overlapping PCR method similar to that commonly used in gene synthesis.
Affiliation: Department of Genetics, University of Georgia, Athens, GA 30602, USA. .
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19: Title: Going in the right direction: mating-type switching of Schizosaccharomyces pombe is controlled by judicious expression of two different swi2 transcripts.
Authors: Yu, Chuanhe, et.al. .
Journal: Genetics, Vol. 190 (3): 977-87, 2012 .
Snippet: We also found that the abp1 gene (human CENPB homolog) controls directionality through swi2 regulation.
Affiliation: Developmental Genetics Section, Gene Regulation and Chromosome Biology Laboratory, National Institutes of Health, National Cancer Institute, Frederick, Maryland 21702-1201, USA. .
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20: Title: Putative CENP-B paralogues are not present at mammalian centromeres.
Authors: Marshall, Owen J, et.al. .
Journal: Chromosoma, Vol. 121 (2): 169-79, 2012 .
Snippet: Although two of the three proteins bound to human centromeres with low affinity when overexpressed as fusion proteins, the strongest candidate, TIGD3, demonstrated no native centromeric binding when using raised antibodies, either in human cells or in cenpb (-/-) mouse ES cells.
Affiliation: Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia. owen.marshall@mcri.edu.au .
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