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21 documents found
1: Title: Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.
Authors: Palmer, Colin J, et.al. .
Journal: Molecular metabolism (Mol Metab), Vol. 6 (10): 1212-1225, 2017 .
Snippet: In addition, the Cdkal1 homolog Cdk5rap1 regulates mitochondrial protein translation and mitochondrial function in skeletal muscle.
Affiliation: Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY 10065, USA. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: abanks@bwh.harvard.edu. .
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2: Title: Inhibition of Cdk5 Promotes β-cell Differentiation from Ductal Progenitors.
Authors: Liu, Ka-Cheuk, et.al. .
Journal: Diabetes, 2017 .
Snippet: By duct-specific overexpression of the endogenous Cdk5 inhibitors Cdk5rap1 or Cdkal1 (which previously have been linked to diabetes in GWAS), as well as deleting cdk5, we validated the role of chemical Cdk5 inhibition in β-cell differentiation by genetic means.
Affiliation: Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, 17177 Stockholm, Sweden. Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, Jette, 1090, Brussels, Belgium. Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8501, Japan. Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen DK-2200, Denmark. Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, 17177 Stockholm, Sweden. olov.andersson@ki.se. .
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3: Title: Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species.
Authors: Fakruddin, Md, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), 2017 .
Snippet: We have recently shown that Cdk5 regulatory subunit-associated protein 1 (Cdk5rap1) specifically converts i6A to ms2i6A at position A37 of four mitochondrial DNA-encoded tRNAs, and that the modification regulates efficient mitochondrial translation and energy metabolism in mammals.
Affiliation: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto 860-8556, Japan. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan. Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. .
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4: Title: Radical S-Adenosylmethionine Enzymes in Human Health and Disease.
Authors: Landgraf, Bradley J, et.al. .
Journal: Annual review of biochemistry (Annu Rev Biochem), Vol. 85, 2016 .
Snippet: Of approximately 114,000 of these enzymes, 8 are known to be present in humans: MOCS1, molybdenum cofactor biosynthesis; LIAS, lipoic acid biosynthesis; CDK5RAP1, 2-methylthio-N(6)-isopentenyladenosine biosynthesis; CDKAL1, methylthio-N(6)-threonylcarbamoyladenosine biosynthesis; TYW1, wybutosine biosynthesis; ELP3, 5-methoxycarbonylmethyl uridine; and RSAD1 and viperin, both of unknown function.
Affiliation: Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802. The Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802; email: squire@psu.edu. .
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5: Title: AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis.
Authors: Ren, Yu, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 362 (2): 174-82, 2015 .
Snippet: AC1MMYR2 attenuated CDK5 activity by functional targeting CDK5RAP1, CDK5 activator p39 and target p-FAK(ser732).
Affiliation: Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China. Department of Head & Neck, Tianjin Cancer Institute and Hospital, Tianjin 300060, China. Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China. Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Electronic address: mei_10668@163.com. Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China; Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, China. Electronic address: kang97061@gmail.com. .
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6: Title: Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans.
Authors: Wei, Fan-Yan, et.al. .
Journal: Cell metabolism (Cell Metab), Vol. 21 (3): 428-42, 2015 .
Snippet: Deficiency in ms(2) modification markedly impaired mitochondrial protein synthesis, which resulted in respiratory defects in Cdk5rap1 knockout (KO) mice.
Affiliation: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan. Department of Molecular Genetics, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan. First Department of Physiology, Kawasaki Medical School, Okayama 701-0192, Japan. Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. Department of Pediatrics and Child Health, Kurume University Graduate School of Medicine, Fukuoka 830-0011, Japan. Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address: tomikt@kumamoto-u.ac.jp. .
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7: Title: CDK5RAP1 deficiency induces cell cycle arrest and apoptosis in human breast cancer cell line by the ROS/JNK signaling pathway.
Authors: Wang, Hongbin, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 33 (3): 1089-96, 2015 .
Snippet: Taken together, these data indicated that CDK5RAP1 deficiency induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells by the ROS/JNK signaling pathway.
Affiliation: Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China. .
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8: Title: Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.
Authors: Kilari, Rajagopal S, et.al. .
Journal: FEBS letters (Febs Lett), Vol. 587 (21): 3464-70, 2013 .
Snippet: We illuminate the metabolism and the cell-signaling activities of inositol pyrophosphates, by showing that regulation of yeast cyclin-kinase by 1-InsP7 is not conserved for mammalian CDK5, and by kinetically characterizing Ddp1p/DIPP-mediated dephosphorylation of 1-InsP7, 5-InsP7 and InsP8.
Affiliation: Department of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV11LY, UK. .
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9: Title: The protein p17 signaling pathways in cancer.
Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol), Vol. 34 (6): 4081-7, 2013 .
Snippet: Moreover, p17 drives the cell cycle into the G0/G1 phase and enhances survival of proliferating cells.
Affiliation: Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea, klaus@hanyang.ac.kr. .
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10: Title: Association between CDK5RAP1 polymorphisms and susceptibility to vitiligo in the Korean population.
Authors: Shin, Min-Kyung, et.al. .
Journal: European journal of dermatology : EJD (Eur J Dermatol), Vol. 22 (4): 495-9, 2012 Jul-Aug .
Snippet: Cyclin-dependent kinase 5 regulatory subunit associated protein 1 (CDK5RAP1) is expressed in neuronal tissues, and cyclin-dependent kinase 5 (CDK5) seems to be critically involved in the migration of neuroblasts during early post-natal development.
Affiliation: Department of Dermatology, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. .
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11: Title: The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA.
Authors: Reiter, Veronika, et.al. .
Journal: Nucleic acids research (Nucleic Acids Res), Vol. 40 (13): 6235-40, 2012 .
Snippet: Here, we show that CDK5RAP1 is a radical SAM enzyme, which postsynthetically converts the RNA modification N6-isopentenyladenosine (i(6)A) into 2-methylthio-N6-isopentenyladenosine (ms(2)i(6)A).
Affiliation: Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Ludwig-Maximilians University, Munich 81377, Germany. .
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12: Title: Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin.
Authors: Padua, Maria B, et.al. .
Journal: Journal of cellular biochemistry (J Cell Biochem), Vol. 107 (6): 1182-8, 2009 .
Snippet: At 24 h, rOvUS decreased expression of 16 genes related to regulation and progression through M (BIRC5, CCNB1, CKS2, CDK5RAP1, CDC20, E2F4, MAD2L2) and G(1) (CDK4, CDKN3, TFDP2), DNA damage checkpoints and repair (RAD17, BRCA1, BCCIP, KPNA2, RAD1).
Affiliation: Department of Animal Sciences, University of Florida, Gainesville, Florida 32611-0910, USA. .
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13: Title: [Functions of Cdk5 in non-neuronal tissues: focusing on regulation of insulin secretion].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme (Tanpakushitsu Kakusan Koso), Vol. 54 (7): 808-12, 2009 .
No Abstract available.
Affiliation: tomikt@kumamoto-u.ac.jp .
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14: Title: Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts.
Authors: Hakimuddin, Fatima, et.al. .
Journal: Nutrition research (New York, N.Y.) (Nutr Res), Vol. 28 (10): 702-13, 2008 .
Snippet: Several genes related to cell cycle regulation, such as CDK5RAP1, RBBP8, and SERTAD1, were up-regulated in these tumors.
Affiliation: Department of Food Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1. .
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15: Title: The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability.
Authors: Moncini, Silvia, et.al. .
Journal: BMC molecular biology (Bmc Mol Biol), Vol. 8, 2007 .
Snippet: BACKGROUND: CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development.
Affiliation: Department of Biology and Genetics, Medical Faculty, University of Milan, Via Viotti 3/5, 20133 Milan, Italy. silvia.moncini@unimi.it .
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16: Title: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Journal: Nature genetics (Nat Genet), Vol. 39 (6): 770-5, 2007 .
Snippet: Observational study and genome-wide association study of gene-disease association.
Affiliation: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. vstein@decode.is .
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17: Title: [Relationship between function and structure of ATP-sensitive K+ (KATP) channels].
Authors: Kurachi, Yoshihisa, et.al. .
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nippon Yakurigaku Zasshi), Vol. 126 (5): 311-6, 2005 .
No Abstract available.
Affiliation: ykurachi@pharma2.med.osaka-u.ac.jp .
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18: Title: Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1.
Authors: Zou, Xianqiong, et.al. .
Journal: Genes & genetic systems (Genes Genet Syst), Vol. 79 (3): 177-82, 2004 .
Snippet: Two novel splice variants of CDK5RAP1, named CDK5RAP1_v3 and CDK5RAP1_v4, were isolated through the large-scale sequencing analysis of a human fetal brain cDNA library.
Affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China. .
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19: Title: Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.
Authors: Ching, Yick-Pang, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 277 (18): 15237-40, 2002 .
Snippet: Neuronal Cdc2-like kinase (Nclk) plays an important role in a variety of cellular processes, including neuronal cell differentiation, apoptosis, neuron migration, and formation of neuromuscular junction.
Affiliation: Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. .
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20: Title: Identification of a common protein association region in the neuronal Cdk5 activator.
Authors: Wang, X, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 275 (41): 31763-9, 2000 .
Snippet: Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity.
Affiliation: Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Peoples Republic of China. .
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