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25 documents found
1: Title: Characterization of germline mutations in familial lung cancer from the Chinese population.
Authors: Kanwal, Madiha, et.al. .
Journal: Gene, Vol. 641, 2018 .
Snippet: Mutations of the five genes (ARHGEF5, ANKRD20A2, ZNF595, ZNF812, MYO18B) may be potential germline mutations of lung cancer.
Affiliation: Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China; Kunming College of Life Sciences, University of Chinese Academy of Sciences, Kunming, China. Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. Computational Biology and Medical Ecology Laboratory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, China. Department of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, China; The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area, Ministry of Education of the People's Republic of China, Kunming, China. Department of Thoracic and Cardiovascular Surgery, The Third Affiliated Hospital of Kunming Medical University (Yunnan Tumor Hospital), Kunming, China; The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area, Ministry of Education of the People's Republic of China, Kunming, China. Electronic address: huangych2001@aliyun.com. Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. Electronic address: caoy@mail.kiz.ac.cn. .
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2: Title: The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition.
Authors: Komiya, Y, et.al. .
Journal: Oncogenesis (Unknown Journal), Vol. 5 (9): e258, 2016 .
Snippet: Here we show that the Rho guanine nucleotide exchange factor (GEF) ARHGEF5 promotes tumor malignancy in a manner dependent on EMT status.
Affiliation: Department of Oncogene Research and Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. Department of Molecular Biology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Hokkaido, Japan. Division of Microbiology and Oncology, Aichi Cancer Center Research Institute, Aichi, Japan. .
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3: Title: Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
Authors: Holmfeldt, Per, et.al. .
Journal: The Journal of experimental medicine (J Exp Med), Vol. 213 (3): 433-49, 2016 .
Snippet: We identified 17 regulators of HSPC repopulation: Arhgef5, Armcx1, Cadps2, Crispld1, Emcn, Foxa3, Fstl1, Glis2, Gprasp2, Gpr56, Myct1, Nbea, P2ry14, Smarca2, Sox4, Stat4, and Zfp251.
Affiliation: Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105. Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105. Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105. Department of Internal Medicine, University of Iowa, Iowa City, IA 52242. Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105 shannon.mckinney-freeman@stjude.org. .
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4: Title: Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
Authors: Gingras, Jacinthe, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 129 (5): 898-911, 2016 .
Snippet: They include multiple members of the DGC, as well as α-catulin, liprin-α1, Usp9x, PI3K, Arhgef5 and Grb2.
Affiliation: Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Laboratory of Synaptogenesis, Dept. of Cell Biology, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland. Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA. Novartis Biomedical Institute, Cambridge, MA 02139, USA. Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA. Laboratory of Synaptogenesis, Dept. of Cell Biology, Nencki Institute of Experimental Biology, Warsaw 02-093, Poland t.proszynski@nencki.gov.pl. .
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5: Title: Milk traits of lactating cows submitted to feed restriction.
Journal: Tropical animal health and production (Trop Anim Health Prod), Vol. 48 (1): 37-43, 2016 .
Snippet: The milk stability to the ethanol test, protein content, milk yield, and somatic cells score were the most important attributes retained by the discriminant analysis.
Affiliation: Department of Animal Science, Faculdade de Agronomia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, DF, Brazil. Centro Nacional de Pesquisa de Clima Temperado, Embrapa, Pelotas, RS, Brazil. Instituto de Ciências Biológicas, Universidade de Rio Grande, São Lourenço do Sul, RS, Brazil. Embrapa Semiárido, Petrolina, PE, Brazil. Empresa de Assistência Técnica e Extensão Rural, EMATER, Erechim, RS, Brazil. Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina, Lages, SC, Brazil. Department of Animal Science, Faculdade de Agronomia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. vivinha.fischer@hotmail.com. , Av. Bento Gonçalves, 7712, Porto Alegre, RS, 91540-000, Brazil. vivinha.fischer@hotmail.com. .
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6: Title: Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
Authors: Lee, Hye-Kyung, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 290 (23): 14740-53, 2015 .
Snippet: ODAM induced RhoA activity and the expression of downstream factors, including ROCK (Rho-associated kinase), by interacting with Rho guanine nucleotide exchange factor 5 (ARHGEF5).
Affiliation: From the Departments of Oral Histology/Developmental Biology and. the Department of Periodontology, Anam Hospital, Korea University, 73 Inchonro, Anam-dong, Seongbuk-gu, Seoul 136-713, Korea, and. Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute, Seoul National University, 101 Daehagro, Chongro-gu, Seoul 110-744, Korea. the Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, 173-82 Gumiro, Seongnam-si, Gyeonggi-do 463-707, Korea. From the Departments of Oral Histology/Developmental Biology and jcapark@snu.ac.kr. .
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7: Title: Sequential or concomitant therapy for eradication of Helicobacter pylori infection: A systematic review and meta-analysis.
Authors: Kim, Joon Sung, et.al. .
Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol), Vol. 30 (9): 1338-45, 2015 .
Snippet: Dichotomous data were pooled to obtain the odds ratio (OR) of the eradication rate with 95% confidence intervals (CIs).
Affiliation: Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea. .
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8: Title: Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and Cyclin D1 Upregulation.
Authors: He, Ping, et.al. .
Journal: Molecular cancer therapeutics (Mol Cancer Ther), Vol. 14 (7): 1671-9, 2015 .
Snippet: We sought to elucidate the role of Rho guanine nucleotide exchange factor 5 (ARHGEF5) in tumorigenesis of lung adenocarcinoma cells.
Affiliation: Cardiothoracic Surgery Department, Southwest Hospital, Third Military Medical University, Chongqing, China. Cardiothoracic Surgery Department, Southwest Hospital, Third Military Medical University, Chongqing, China. WangHDSci@163.com. .
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9: Title: Targeting rho guanine nucleotide exchange factor ARHGEF5/TIM with auto-inhibitory peptides in human breast cancer.
Authors: Huang, Ou, et.al. .
Journal: Amino acids, Vol. 47 (6): 1239-46, 2015 .
Snippet: The oncogenic protein ARHGEF5/TIM has long been known to express specifically in human breast cancer and other tumors, which is an important member of Rho guanine nucleotide exchange factors that activate Rho-family GTPases by promoting GTP/GDP exchange.
Affiliation: Department of Surgery, Ruijin Hospital, Medical School of Shanghai Jiaotong University, Shanghai, 200025, China. .
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10: Title: The auto-inhibitory state of Rho guanine nucleotide exchange factor ARHGEF5/TIM can be relieved by targeting its SH3 domain with rationally designed peptide aptamers.
Authors: He, Ping, et.al. .
Journal: Biochimie, Vol. 111, 2015 .
Snippet: The short isoform of Rho guanine nucleotide exchange factor ARHGEF5 is known as TIM, which plays diverse roles in, for example, tumorigenesis, neuronal development and Src-induced podosome formation through the activation of its substrates, the Rho family of GTPases.
Affiliation: Department of Cardiothoracic Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. College of Bioengineering, Chongqing University, Chongqing 400044, China. Department of Cardiothoracic Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: wuweiyahoo@sohu.com. .
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11: Title: Vasculature of the hive: heat dissipation in the honey bee (Apis mellifera) hive.
Authors: Bonoan, Rachael E, et.al. .
Journal: Die Naturwissenschaften (Naturwissenschaften), Vol. 101 (6): 459-65, 2014 .
Snippet: Residing in temperate environments, honey bees (Apis mellifera) work especially hard to maintain brood comb temperature between 32 and 36 °C.
Affiliation: Department of Biology, Tufts University, 163 Packard Ave, Medford, MA, USA. .
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12: Title: Identification of tumor antigens that elicit a humoral immune response in the sera of Chinese esophageal squamous cell carcinoma patients by modified serological proteome analysis.
Authors: Gao, Hongjun, et.al. .
Journal: Cancer letters (Cancer Lett), Vol. 344 (1): 54-61, 2014 .
Snippet: From these, 105 kDa heat shock protein (HSP105) and triosephosphate isomerase (TIM) were further evaluated and we determined they could induce autoantibody responses in ESCC sera and are highly expressed in ESCC tissues.
Affiliation: Clinical Laboratory of China Meitan General Hospital, Beijing, PR China. Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. Department of Thoracic Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. Department of Thoracic Surgery, Navy General Hospital of Chinese PLA, Beijing, PR China. Center for Basic Medical Science, Navy General Hospital of Chinese PLA, Beijing, PR China. State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. Center for Basic Medical Science, Navy General Hospital of Chinese PLA, Beijing, PR China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. Electronic address: xhzdoctor@yahoo.cn. .
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13: Title: Co-expression of Rho guanine nucleotide exchange factor 5 and Src associates with poor prognosis of patients with resected non-small cell lung cancer.
Authors: He, Ping, et.al. .
Journal: Oncology reports (Oncol Rep), Vol. 30 (6): 2864-70, 2013 .
Snippet: Therefore, we evaluated the expression of ARHGEF5 and Src in resected NSCLC tissues and the correlation of co-expression of ARHGEF5 and Src and the prognosis of patients with resected NSCLC.
Affiliation: Department of Cardiothoracic Surgery, Southwest Hospital, Third Military Medical University, 400038 Chongqing, P.R. China. .
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14: Title: TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine.
Authors: Jemielity, Stephanie, et.al. .
Journal: PLoS pathogens (Plos Pathog), Vol. 9 (3): e1003232, 2013 .
Snippet: All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments.
Affiliation: Division of Respiratory Diseases Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America. .
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15: Title: Microsatellite loci over a thirty-three year period for a malaria parasite (Plasmodium mexicanum): bottleneck in effective population size and effect on allele frequencies.
Authors: Schall, J J, et.al. .
Journal: Parasitology, Vol. 140 (1): 21-8, 2013 .
Snippet: Microsatellite allele frequencies for 4 loci were followed in a population of Plasmodium mexicanum, a malaria parasite of lizards in California USA at 1 site from 1978 to 2010.
Affiliation: Department of Biology, University of Vermont, Burlington, VT 05405, USA. jschall@uvm.edu .
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16: Title: TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A.
Authors: Mihira, Hajime, et.al. .
Journal: Journal of biochemistry (J Biochem), Vol. 151 (2): 145-56, 2012 .
Snippet: Whereas activation of Rho signals via TGF-β-induced non-Smad signals has been implicated in epithelial-mesenchymal transition (EMT), we found that Arhgef5, a guanine nucleotide exchange factor, is induced by Smad signals and contributes to the TGF-β2-induced α-SMA expression in MS-1 cells.
Affiliation: Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. .
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17: Title: The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
Authors: Kuroiwa, Miho, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 124 (Pt 10): 1726-38, 2011 .
Snippet: Using an inducible system for Src activation, we found that Src-induced podosome formation depends upon the Src SH3 domain, and identified Arhgef5 as a Src SH3-binding protein.
Affiliation: Department of Oncogene Research, Research institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. .
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18: Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
Authors: Wang, Zhenglong, et.al. .
Journal: The Journal of biological chemistry (J Biol Chem), Vol. 284 (42): 28599-606, 2009 .
Snippet: Arhgef5 can strongly activate RhoA and RhoB and weakly RhoC and RhoG, but not Rac1, RhoQ, RhoD, or RhoV, in transfected human embryonic kidney 293 cells.
Affiliation: Program for Vascular Biology and Therapeutics and Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520,, USA. .
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19: Title: Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Authors: Biagini, Giuseppe, et.al. .
Journal: Journal of neuropathology and experimental neurology (J Neuropath Exp Neur), Vol. 67 (7): 687-701, 2008 .
Snippet: Using FosB/DeltaFosB markers, we found induction of FosB/DeltaFosB immunopositivity in CA3 neurons of young but not in adult rats.
Affiliation: Dipartimento di Scienze Biomediche, Università di Modena e Reggio Emilia, Modena, Italy. gbiagini@unimore.it .
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20: Title: 8-quinolyl phosphate as a substrate for the fluorimetric determination of alkaline phosphatase.
Authors: Zhu, Xiaojing, et.al. .
Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta), Vol. 377 (1-2): 150-3, 2007 .
Snippet: With this method, ALP could be applied to assess ALP in human serum and the results were evaluated by comparison with a standard colorimetric assay using p-nitrophenyl phosphate as ALP substrate.
Affiliation: Department of Chemistry, Shandong Normal University, Jinan, 250014, China. .
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