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417 documents found
1: Title: Genes involved in leukotriene synthesis pathway are dynamically regulated during lung development in Rhesus monkeys.
Authors: Xia, Wanmin, et.al. .
Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids), Vol. 122, 2017 .
Snippet: RESULTS: The results showed that the expression levels of PLA2G1B, PLA2G10, PLA2G2D, ALOX5, and ALOX5AP increased dramatically in the lung of Rhesus monkey, reflecting the changes in the pulmonary environment after delivery.
Affiliation: Department of Pediatric Respiratory, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Department of Respiratory, Chengdu Women & Children's Hospital, Chengdu 610091, China. The Vascular Remodeling and Developmental Defects Research Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Department of Basic Research, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China; State Key Laboratory of Molecular Oncology, Department of Aetiology and Carcinogenesis, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. State Key Laboratory of Molecular Oncology, Department of Aetiology and Carcinogenesis, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Lung Development and Diseases, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address: huajingwan@scu.edu.cn. Department of Pediatric Respiratory, West China Second University Hospital, Sichuan University, Chengdu 610041, China; The Vascular Remodeling and Developmental Defects Research Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Electronic address: hanmin@vip.163.com. .
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2: Title: Identification of Proteomic Features To Distinguish Benign Pulmonary Nodules from Lung Adenocarcinoma.
Authors: Codreanu, Simona G, et.al. .
Journal: Journal of proteome research (J Proteome Res), Vol. 16 (9): 3266-3276, 2017 .
Snippet: PRM analyses confirmed significant nodule-specific abundance of 10 proteins including ALOX5, ALOX5AP, CCL19, CILP1, COL5A2, ITGB2, ITGAX, PTPRE, S100A12, and SLC2A3 and significant ADC-specific abundance of CEACAM6, CRABP2, LAD1, PLOD2, and TMEM110-MUSTN1.
Affiliation: Department of Biochemistry, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Department of Biostatistics, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Center for Quantitative Sciences, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Department of Cancer Biology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States. Veterans Affairs, Tennessee Valley Healthcare System , Nashville, Tennessee 37212, United States. .
3: Title: Preliminary profiling of blood transcriptome in a rat model of hemorrhagic shock.
Authors: Braga, D, et.al. .
Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (maywood)), Vol. 242 (14): 1462-1470, 2017 .
Snippet: The transcriptome of whole blood from shocked animals shows modulation of genes related to inflammation and immune response (Tlr13, Il1b, Ccl6, Lgals3), antioxidant functions (Mt2A, Mt1), tissue injury and repair pathways (Gpnmb, Trim72) and lipid mediators (Alox5ap, Ltb4r, Ptger2) compared with control animals.
Affiliation: 1 Dipartimento di Scienze della Salute, Università Degli Studi di Milano, Milan 20142, Italy. 2 Fondazione Filarete, Milan 20139, Italy. 3 Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. 4 Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan 20133, Italy. 5 Department of Anesthesiology & Critical Care, VA San Diego Healthcare System, San Diego, CA 92103, USA. .
4: Title: Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate.
Authors: Batistel, Fernanda, et.al. .
Journal: Journal of animal science and biotechnology (J Anim Sci Biotechnol), Vol. 8, 2017 .
Snippet: Feeding AAC led to greater PMNL expression of genes related with inflammation response (DDX58), oxidative stress response (MPO), eicosanoid metabolism (PLA2G4A and ALOX5AP), transcription regulation (PPARG), and cellular adhesion (TLN1).
Affiliation: Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801 USA. Department of Dairy Science, South Dakota State University, Brookings, SD USA. Department of Food Science and Technology, University College of Agriculture & Environmental Sciences, The Islamia University of Bahawalpur, Bahawalpur, Punjab Pakistan. College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193 China. Zinpro Corporation, Eden Prairie, MN USA. .
5: Title: Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed.
Authors: Seroussi, Eyal, et.al. .
Journal: Genetics, selection, evolution : GSE (Genet Sel Evol), Vol. 49 (1): 19, 2017 .
Snippet: Similar to other studies, the most significant VGR was detected on OAR10, in a region that contains candidate genes affecting horn type (RXFP2), climate adaptation (ALOX5AP), fiber diameter (KATNAl1), coat pigmentation (FRY) and genes associated with fat distribution.
Affiliation: Institute of Animal Science, ARO, The Volcani Center, PO Box 15159, 7528809, Rishon LeZion, Israel. Institute of Animal Science, ARO, The Volcani Center, PO Box 15159, 7528809, Rishon LeZion, Israel. gootwine@agri.gov.il. .
6: Title: The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related interstitial lung disease: a multicentre European Scleroderma Trials and Research group (EUSTAR) study.
Authors: Kowal-Bielecka, Otylia, et.al. .
Journal: Rheumatology (Oxford, England) (Rheumatology (oxford)), Vol. 56 (5): 844-852, 2017 .
Snippet: Objectives.: The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important mediators of inflammation and connective tissue remodelling.
Affiliation: Department of Rheumatology and Internal Medicine. Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland. Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France. Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen. Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Experimental and Clinical Medicine, Section of Internal Medicine and Division of Rheumatology, AOUC, University of Florence, Florence, Italy. Department of Rheumatology, Lund University, Skåne University Hospital, Lund, Sweden. Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland. Clinic of Rheumatology, University of Lübeck, Lübeck, Germany. Department of Orthopedics and Traumatology. Department of Statistics and Medical Informatics. Department of Medical Pathomorphology. Department of Allergology and Internal Medicine. Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland. .
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7: Title: Effects of precalving body condition and prepartum feeding level on gene expression in circulating neutrophils.
Authors: Crookenden, M A, et.al. .
Journal: Journal of dairy science (J Dairy Sci), Vol. 100 (3): 2310-2322, 2017 .
Snippet: Precalving BCS altered the inflammatory state of neutrophils, with significant increases in overall gene expression of antimicrobial peptides (BNBD4 and DEFB10) and the anti-inflammatory cytokine IL10, and significantly decreased expression of proinflammatory cytokine IL23A in thinner cows (BCS 4) compared with cows calving at BCS 5. Feeding level had a time-dependent effect on gene expression; for example, increased expression of genes involved in leukotriene synthesis (PLA2G4A and ALOX5AP) occurred only at 1 wk postcalving in cows overfed (125% of requirements) precalving compared with those offered 75% of maintenance requirements.
Affiliation: DairyNZ, c/o University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand; Institute of Vet, Animal and Biomedical Sciences, Massey University, Palmerston North 4442, New Zealand. Electronic address: mallory.crookenden@dairynz.co.nz. DairyNZ, c/o University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand. Institute of Vet, Animal and Biomedical Sciences, Massey University, Palmerston North 4442, New Zealand; AgResearch, Hopkirk Research Institute, Palmerston North 4442, New Zealand. Institute of Vet, Animal and Biomedical Sciences, Massey University, Palmerston North 4442, New Zealand. DairyNZ, Cnr Ruakura and Morrinsville Rds (SH26), Newstead, Hamilton 3284, New Zealand. Department of Animal and Avian Sciences, University of Maryland, College Park 20742. University of Queensland, Centre for Clinical Research, Herston, Queensland 4029, Australia. Department of Animal Sciences, University of Illinois, Urbana 61801. .
8: Title: The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects.
Authors: Chen, Zhongjun, et.al. .
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci), Vol. 38 (4): 579-587, 2017 .
Snippet: The association between ALOX5AP SG13S114 polymorphism and ischemic stroke (IS) susceptibility has extensively been investigated, especially in white populations; however, the results were inconclusive.
Affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China. Department of Neurosurgery, Nanjing Brain Hospital Affiliated with Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China. Department of Neurosurgery, Sir Shaw Hospital, Nanjing Medical University, Nanjing, 211100, Jiangsu, China. Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. lilixin2@hotmail.com. .
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9: Title: Genetic Predictors of Drug Hypersensitivity.
Authors: Cornejo-Garcia, Jose A, et.al. .
Journal: Current pharmaceutical design (Curr Pharm Des), Vol. 22 (45): 6725-6733, 2016 .
Snippet: The predictors of DHRs against NSAIDs are mostly linked to metabolism of eicosanoids (ALOX5, ALOX5AP, TBXAS1, PTGDR, CYSLTR1).
Affiliation: Faculte de Medecine, Batiment C 2eme etage, 9 avenue de la Foret de Haye - B.P. 184, 54505 Vandoeuvre- les-Nancy CEDEX, France. .
10: Title: Exome sequencing in Thai patients with familial obesity.
Authors: Kaewsutthi, S, et.al. .
Journal: Genetics and molecular research : GMR (Genet Mol Res), Vol. 15 (2), 2016 .
Snippet: The minor allele frequency of 14 of these genes (ALOX5AP, COL9A2, DEFB126, GDPD4, HCRTR1, MLL3, OPLAH, OR4C45, PRIM2, RXFP2, TIGD6, TRPM8, USP49, and ZNF596) was low, indicating causal variants that could be associated with complex traits or diseases.
Affiliation: Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. .
11: Title: Genetic Variants in the Transcriptional Regulatory Region of the ALOX5AP gene and Susceptibility to Ischemic Stroke in Chinese Populations.
Authors: Yang, Dongzhi, et.al. .
Journal: Scientific reports (Sci Rep), Vol. 6, 2016 .
Snippet: No coding sequence variants of the ALOX5AP gene that lead to amino acid substitutions have been identified.
Affiliation: School of life sciences of Zhengzhou University, Zhengzhou, 450052, China. Department of Neurology, The First People's Hospital of Zhengzhou, Zhengzhou, 450000, China. Department of Medical Genetics &Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China. .
12: Title: Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.
Authors: Diakite, Brehima, et.al. .
Journal: Journal of genetics (J Genet), Vol. 95 (2): 303-9, 2016 .
Snippet: According to the risk factors of ischaemic stroke, a positive correlation was observed only between SG13S114 variant of ALOX5AP gene and hypertension (Pc = 0.026).
Affiliation: Faculty of Medicine and Pharmacy 14, Department of Genetics and Molecular Pathology Laboratory (LGPM), Hassan II University, 9154 Casablanca, Morocco.br.diakite@yahoo.fr. .
13: Title: Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways.
Authors: Postula, Marek, et.al. .
Journal: Experimental and therapeutic medicine (Exp Ther Med), Vol. 12 (1): 415-421, 2016 .
Snippet: The aim of the present study was to investigate a possible association between the accumulation of rare coding variants in the genes for arachidonate 5-lipoxygenase (ALOX5) and ALOX5-activating protein (ALOX5AP), and corresponding production of leukotrienes (LTs) in patients with type 2 diabetes mellitus (T2DM) receiving acetylsalicylic therapy.
Affiliation: Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw 02-097, Poland; Perioperative Genomics Laboratory, Penn State University, College of Medicine, Hershey, PA 17033, USA. Perioperative Genomics Laboratory, Penn State University, College of Medicine, Hershey, PA 17033, USA. Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw 02-097, Poland; Department of Cardiology and Hypertension, Central Clinical Hospital, The Ministry of the Interior, Warsaw 02-507, Poland. Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw 02-097, Poland. Department of Cardiology, Medical University of Warsaw, Warsaw 02-091, Poland. Department of Cardiology and Hypertension, Central Clinical Hospital, The Ministry of the Interior, Warsaw 02-507, Poland; Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw 02-106, Poland. .
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14: Title: Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions.
Authors: Olivry, Thierry, et.al. .
Journal: The Journal of investigative dermatology (J Invest Dermatol), Vol. 136 (10): 1961-9, 2016 .
Snippet: Other known pruritogenic pathways were also activated: there was significant up-regulation of genes encoding proteases cathepsin S (CTSS), mast cell chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leukotriene-synthesis enzymes (ALOX5, ALOX5AP, and LTA4H).
Affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, USA. Computational Biology, Target Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, USA. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA. Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, USA; Department of Population Health and Pathobiology, College of Veterinary Medicine, Research Triangle Park, North Carolina, USA. Stiefel, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. Electronic address: carlos.x.peredo@stiefel.com. Safety Assessment, Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, NC, USA. Stiefel, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. .
15: Title: Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish.
Authors: Chatzopoulou, Antonia, et.al. .
Journal: Endocrinology, Vol. 157 (7): 2772-84, 2016 .
Snippet: Alox5ap is involved in eicosanoid biosynthesis, but the increase in leukotriene B4 concentration upon amputation was abolished, and lipoxin A4 levels were unaffected by beclomethasone.
Affiliation: Institute of Biology, Leiden University, 2333CC Leiden, The Netherlands. .
16: Title: ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.
Authors: Elias, Ivet, et.al. .
Journal: Diabetes, Vol. 65 (8): 2139-50, 2016 .
Snippet: ALOX5 and ALOX5AP expression is increased in humans and rodents with obesity and insulin resistance.
Affiliation: Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain Department of Animal Health and Anatomy, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain sylvie.franckhauser@uab.es. .
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17: Title: A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.
Authors: Qu, Zhengyi, et.al. .
Journal: International journal of clinical and experimental medicine (Unknown Journal), Vol. 8 (11): 21343-50, 2015 .
Snippet: By utilizing TaqMan probe based real-time fluorescent PCR and DNA sequencing method, this study focused on 6 SNPs of ALOX5AP gene and analyzed the association with the hereditary susceptibility of cerebral infarction.
Affiliation: Department of Neurology, The Fourth Affiliated Clinical College, Harbin Medical University 37 Yiyuan Street, Nangang District, Harbin 150001, China. Department of Neurology, The Second Affiliated Hospital of Harbin Medical University 246 Xuefu Road, Harbin 150086, Heilongjiang, China. .
18: Title: Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis.
Authors: Larson, Nicholas B, et.al. .
Journal: Human genetics (Hum Genet), Vol. 135 (4): 415-23, 2016 .
Snippet: Of these, two significant loci specific to non-Hispanic white participants, rs17074898 at ALOX5AP (P = 1.78E-08) and rs7521237 at KIAA1614 (P = 2.2E-08), would not have met statistical significance using univariate analyses.
Affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Larson.nicholas@mayo.edu. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Department Pathology and Laboratory Medicine, College of Medicine, University of Vermont, Burlington, VT, USA. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. .
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19: Title: Down-regulation of NF-κB expression by n-3 fatty acid-rich linseed oil is modulated by PPARγ activation, eicosanoid cascade and secretion of cytokines by macrophages in rats fed partially hydrogenated vegetable fat.
Authors: Rao, Y Poorna Chandra, et.al. .
Journal: European journal of nutrition (Eur J Nutr), Vol. 56 (3): 1135-1147, 2017 .
Snippet: RESULTS: The macrophages from rats fed PHVF showed higher levels of total cholesterol and free cholesterol as compared to those from rats fed GNO and LSO.
Affiliation: Department of Lipid Science, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, 570 020, India. Department of Lipid Science, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, 570 020, India. lokesh_lipids@yahoo.co.in. .
20: Title: Genetics of ischemic stroke: An Indian scenario.
Authors: Kumar, Amit, et.al. .
Journal: Neurology India (Neurol India), Vol. 64 (1): 29-37, 2016 Jan-Feb .
Snippet: Combined linkage/association studies have demonstrated that genes encoding phosphodiesterase 4D (PDE4D) and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) confer risk for stroke.
Affiliation: Department of Neurology, All Institute of Medical Sciences, New Delhi, India. .
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