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47 documents found
1: Title: Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson's Disease, and Other Disorders.
Authors: Abdel-Magid, Ahmed F .
Journal: ACS medicinal chemistry letters (Unknown Journal), Vol. 8 (6): 595-597, 2017 .
No Abstract available.
Affiliation: Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India. .
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2: Title: [(3)H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.
Authors: Louis, Justin V, et.al. .
Journal: Neuropharmacology, Vol. 118, 2017 .
Snippet: Adaptor-associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of serine/threonine kinases, plays a role in modulating clatherin coated endocytosis of specific surface receptors.
Affiliation: Biology and Chemistry, Bristol-Myers Squibb Biocon Research Center, Bangalore, India. Neuroscience Biology, Neuroscience Chemistry, Radiochemistry and Veterinary Science, Research & Development, Bristol-Myers Squibb Company, Wallingford, CT, USA. Neuroscience Biology, Neuroscience Chemistry, Radiochemistry and Veterinary Science, Research & Development, Bristol-Myers Squibb Company, Wallingford, CT, USA. Electronic address: yuwenli@yahoo.com. .
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3: Title: Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.
Authors: Bekerman, Elena, et.al. .
Journal: The Journal of clinical investigation (J Clin Invest), Vol. 127 (4): 1338-1352, 2017 .
Snippet: We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins AP1 and AP2, are essential for hepatitis C virus (HCV) infection, but the underlying mechanism and relevance to other viruses or in vivo infections remained unknown.
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4: Title: Lineage-specific proteins essential for endocytosis in trypanosomes.
Authors: Manna, Paul T, et.al. .
Journal: Journal of cell science (J Cell Sci), Vol. 130 (8): 1379-1392, 2017 .
Snippet: We identified the trypanosome AP-1 complex, Trypanosoma brucei (Tb)EpsinR, several endosomal SNAREs plus orthologues of SMAP and the AP-2 associated kinase AAK1 as interacting with clathrin.
Affiliation: School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK. The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. School of Life Sciences, University of Nottingham, Nottingham NG2 7UH, UK. California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA. School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK mfield@mac.com. .
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5: Title: Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.
Authors: Kadlecova, Zuzana, et.al. .
Journal: The Journal of cell biology (J Cell Biol), Vol. 216 (1): 167-179, 2017 .
Snippet: Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by conformational changes in response to phosphatidylinositol-4,5-bisphosphate (PIP2) and cargo binding at multiple sites.
Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390. Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122. Department of Physics and Astronomy, University of Denver, Denver, CO 80208. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 sandra.schmid@utsouthwestern.edu. .
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6: Title: Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma.
Authors: Jang, Jin Sung, et.al. .
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol), Vol. 11 (11): 1891-1900, 2016 .
Snippet: RESULTS: In four ALK FISH-positive/IHC-negative cases, no EML4-ALK fusion gene was observed by NGS, but in one case using fresh frozen tissue, we identified EML4-baculoviral AIP repeat containing 6 gene (BIRC6) and AP2 associated kinase 1 gene (AAK1)-ALK fusion genes.
Affiliation: Genome Analysis Core, Medical Genome Facility, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota. Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee. Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Division of Epidemiology, Mayo Clinic, Rochester, Minnesota. Genome Analysis Core, Medical Genome Facility, Mayo Clinic, Rochester, Minnesota; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: Yi.Joanne@Mayo.edu. .
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7: Title: ATGs help MHC class II, but inhibit MHC class I antigen presentation.
Authors: Loi, Monica, et.al. .
Journal: Autophagy, Vol. 12 (9): 1681-2, 2016 .
Snippet: Decreased internalization in the absence of ATG5 or ATG7 leads to MHC class I surface stabilization on dendritic cells and macrophages, resulting in elevated CD8(+) T cell responses during viral infections and improved immune control.
Affiliation: a Viral Immunobiology , Institute of Experimental Immunology, University of Zurich , Zurich , Switzerland. b Department of Pathology and Immunology , School of Medicine, University of Geneva , Geneva , Switzerland. .
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8: Title: Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
Authors: Kostich, Walter, et.al. .
Journal: The Journal of pharmacology and experimental therapeutics (J Pharmacol Exp Ther), Vol. 358 (3): 371-86, 2016 .
Snippet: One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin.
Affiliation: Research and Development, Neuroscience Biology (W.K., Y.-W.L., J.F., A.E., C.B., M.G., T.M., J.M.B., M.L., Y.H., Y.L., R.P., R.Z., R.W., L.K., L.B., C.M.C., C.F.A.), Neuroscience Chemistry (C.D., J.B., J.E.M.), Preclinical Candidate Optimization (A.B., J.E.G., K.A.L., K.S.S.), and Discovery Toxicology (R.D.), Bristol-Myers Squibb, Wallingford, Connecticut; Research and Development, Leads Discovery and Optimization, Bristol-Myers Squibb, Pennington, New Jersey (K.O., J.L.); BMS Biocon Research Center, Bangalore, India (K.D., J.V.L., S.N., M.D., S.E., P.V., V.S., M.L.D, G.S., A.K., V.K.H., S.M., R.K.V., S.J.N.); Lexicon Pharmaceuticals, The Woodlands, Texas (B.D.H., K.B., J.A., K.S., A.N., A.W., J.S., B.Z., T.H.L., G.Y.); and Lexicon Pharmaceuticals, Basking Ridge, New Jersey (Y.B., A.M., K.C.). Research and Development, Neuroscience Biology (W.K., Y.-W.L., J.F., A.E., C.B., M.G., T.M., J.M.B., M.L., Y.H., Y.L., R.P., R.Z., R.W., L.K., L.B., C.M.C., C.F.A.), Neuroscience Chemistry (C.D., J.B., J.E.M.), Preclinical Candidate Optimization (A.B., J.E.G., K.A.L., K.S.S.), and Discovery Toxicology (R.D.), Bristol-Myers Squibb, Wallingford, Connecticut; Research and Development, Leads Discovery and Optimization, Bristol-Myers Squibb, Pennington, New Jersey (K.O., J.L.); BMS Biocon Research Center, Bangalore, India (K.D., J.V.L., S.N., M.D., S.E., P.V., V.S., M.L.D, G.S., A.K., V.K.H., S.M., R.K.V., S.J.N.); Lexicon Pharmaceuticals, The Woodlands, Texas (B.D.H., K.B., J.A., K.S., A.N., A.W., J.S., B.Z., T.H.L., G.Y.); and Lexicon Pharmaceuticals, Basking Ridge, New Jersey (Y.B., A.M., K.C.) Charlie.Albright@BMS.com brian.zambrowicz@regeneron.com. .
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9: Title: Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses.
Authors: Loi, Monica, et.al. .
Journal: Cell reports (Cell Rep), Vol. 15 (5): 1076-87, 2016 .
Snippet: Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B.
Affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland. Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva, Switzerland. Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva, Switzerland; Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva 1205, Switzerland. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Dermatology, Medical Center; ZBSA Center for Biological Systems Analysis; BIOSS Centre for Biological Signalling Studies; and FRIAS Freiburg Institute for Advanced Studies, University of Freiburg, 79104 Freiburg, Germany. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva, Switzerland; Department of Neuropathology, University Medical Center, 37099 Göttingen, Germany. Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland. Electronic address: christian.muenz@uzh.ch. Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland; Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva, Switzerland; Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva 1205, Switzerland. Electronic address: monique.ghannage@unige.ch. .
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10: Title: Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Authors: Sorrell, Fiona J, et.al. .
Journal: Structure (London, England : 1993) (Structure), Vol. 24 (3): 401-11, 2016 .
Snippet: Here we report the first high-resolution structures of kinases AAK1 and BIKE in complex with two drug candidates.
Affiliation: Nuffield Department of Clinical Medicine, Structural Genomics Consortium and Target Discovery Institute (TDI), University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK. Nuffield Department of Clinical Medicine, Structural Genomics Consortium and Target Discovery Institute (TDI), University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK; Institute for Pharmaceutical Chemistry, Buchmann Institute for Life Sciences Campus Riedberg, Goethe-University Frankfurt, 60438 Frankfurt am Main, Germany. Electronic address: knapp@pharmchem.uni-frankfurt.de. .
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11: Title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Authors: So, Jonathan, et.al. .
Journal: Science signaling (Sci Signal), Vol. 8 (371): rs3, 2015 .
Snippet: Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis by enhancing endocytosis of the TRAIL receptors.
Affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark. Cell Communication Team, The Institute of Cancer Research, London SW3 6JB, UK. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark. Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), DK-2200 Copenhagen, Denmark. linding@lindinglab.org claus.jorgensen@cruk.manchester.ac.uk colwill@lunenfeld.ca. Cell Communication Team, The Institute of Cancer Research, London SW3 6JB, UK. linding@lindinglab.org claus.jorgensen@cruk.manchester.ac.uk colwill@lunenfeld.ca. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. linding@lindinglab.org claus.jorgensen@cruk.manchester.ac.uk colwill@lunenfeld.ca. .
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12: Title: AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
Authors: Neveu, Gregory, et.al. .
Journal: Journal of virology (J Virol), Vol. 89 (8): 4387-404, 2015 .
Snippet: AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in the endocytic and secretory pathways.
Affiliation: Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Cell Sciences Imaging Facility, Stanford University School of Medicine, Stanford, California, USA. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA seinav@stanford.edu. .
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13: Title: Dysfunction of endocytic kinase AAK1 in ALS.
Authors: Shi, Bingxing, et.al. .
Journal: International journal of molecular sciences (Int J Mol Sci), Vol. 15 (12): 22918-32, 2014 .
Snippet: Using the yeast two-hybrid system, we identified the adaptor-associated kinase 1 (AAK1), a regulatory protein in clathrin-coated vesicle endocytic pathway that selectively interacted with the mutant but not the wild-type SOD1.
Affiliation: Department of Neuroscience, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. bxsin@yahoo.com. Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA. sdconner@umn.edu. Department of Neuroscience, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA. jian.liu@xjtlu.edu.cn. .
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14: Title: Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure.
Authors: Zhou, Mei, et.al. .
Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry), Vol. 56, 2015 .
Snippet: Additional experiments showed that the imbalance of cell membrane HCN1 and HCN2 expression under chronic morphine exposure was related to an increase in expression of TPR containing Rab8b interacting protein (TRIP8b) (1a-4) and TRIP8b (1b-2), and phosphorylation of protein kinase A (PKA) and adaptor protein 2 μ2 (AP2 μ2).
Affiliation: Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China. Department of Neuropsychopharmacology, Medical School of China Three Gorges University, Yichang, 443002, China. Electronic address: hezhi2003@126.com.cn. Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Institute of Brain Research, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: ljguo@hust.edu.cn. .
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15: Title: Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion.
Authors: Li, Chang-jun, et.al. .
Journal: Molecular neurobiology (Mol Neurobiol), Vol. 50 (2): 704-20, 2014 .
Snippet: Protein kinase A (PKA) and TPR containing Rab8b interacting protein (TRIP8b) can modulate GABAB receptors cell surface stability and HCN channel trafficking, respectively, and adaptor-associated kinase 1 (AAK1) inhibits the function of the major TRIP8b-interacting protein adaptor protein 2 (AP2) via phosphorylating the AP2 μ2 subunit.
Affiliation: Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. .
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16: Title: AQU-1, a chromosomal class C β-lactamase, among clinical Aeromonas dhakensis isolates: distribution and clinical significance.
Authors: Wu, Chi-Jung, et.al. .
Journal: International journal of antimicrobial agents (Int J Antimicrob Agents), Vol. 42 (5): 456-61, 2013 .
Snippet: In this study, a chromosomal gene, blaAQU-1, was identified in A. dhakensis AAK1 that constitutes a 1143-bp open reading frame and is 87% identical to the gene encoding CepH in Aeromonas hydrophila.
Affiliation: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan, Taiwan. .
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17: Title: A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.
Authors: Shahani, Vijay M, et.al. .
Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem), Vol. 21 (17): 5618-28, 2013 .
Snippet: Initial screening against the kinome, prompted by the purine scaffold's history for targeting ATP binding pockets, suggests possible targeting of the JAK family kinases, as well for ABL1 (nonphosphorylated F317L) and AAK1.
Affiliation: Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada. .
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18: Title: Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.
Authors: Neveu, Gregory, et.al. .
Journal: PLoS pathogens (Plos Pathog), Vol. 8 (8): e1002845, 2012 .
Snippet: Furthermore, AAK1 and GAK, serine/threonine kinases known to stimulate binding of AP2M1 to host cargo proteins, regulate core-AP2M1 binding and are essential for HCV assembly.
Affiliation: Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America. .
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19: Title: Genome sequence of a novel human pathogen, Aeromonas aquariorum.
Authors: Wu, Chi-Jung, et.al. .
Journal: Journal of bacteriology (J Bacteriol), Vol. 194 (15): 4114-5, 2012 .
Snippet: We present here the first genome sequence of A. aquariorum strain AAk1, which was isolated as the sole pathogen from the blood of a patient with septicemia and necrotizing fasciitis.
Affiliation: Graduate Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, Tainan, Taiwan. .
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20: Title: Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
Authors: Ultanir, Sila K, et.al. .
Journal: Neuron, Vol. 73 (6): 1127-42, 2012 .
Snippet: We further employed chemical genetics and identified NDR1/2 substrates in the brain, including two proteins involved in intracellular vesicle trafficking: AAK1 (AP-2 associated kinase) and Rabin8, a GDP/GTP exchange factor (GEF) of Rab8 GTPase.
Affiliation: Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA. sila.ultanir@gmail.com .
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