What is Go3R?

Go3R is a semantic search engine, that ...
  • provides endpoint-centered semantic literature search for toxicological information (e.g. as required for REACH).
  • highlights animal testing alternatives.
  • organizes 22 million abstracts listed in PubMed and TOXNET in an accurate table of contents.
  • enables for fast bibliometric analysis.
The novel web-based search engine Go3R has been created over the last three years to allow finding relevant hazard information and data as well as currently updating information on available test methods that meet the requirement to replace, reduce and refine animal testing. Go3R provides an endpoint-centered literature search to all scientists and regulatory authorities seeking for toxicological information. Search results are presented automatically linked to an “intelligent table of contents” which enables the user to sort the literature listed in PubMed or the Toxicology Data Network (TOXNET) in a fast and comprehensive manner. Retrieved documents are automatically organized in categories relating to the IUCLID5 chapters, the categorisation schema used during substance registration under the REACH regulation.
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Search Examples

Substance specific search for hydroxycitronellal?
All documents found for the substance hydroxycitronellal (listed on the right hand side) have been sorted into the “table of contents” listing categories defined by chapter 7 (toxicological information) of the IUCLID5 system, listed on the left hand side, with the figures next to the categories indicating the number of documents retrieved. Clicking onto the respective categories reveals the specific sub-list of documents.
Which 3Rs methods are being used to test the potency of botulinum toxin type A?
Search for 'Botulinum Toxins' and 'Potency Testing (always accepting query suggestions)' and filter by '3Rs Alternative Methods (by Area of Use)': Clicking onto the small triangle next to the categories in the table of contents, opens the respective category and reveals further sub-categories.
Which 3Rs methods are being used to assess the endpoint skin sensitization?
Search for 'Skin Sensitization' and browse the section '3Rs Alternative Methods (by Area of Use)’ in the table of contents to find a list of replacement and reduction/refinement methods for skin sensitisation testing. Again, clicking onto a specific test method provides a list of documents (on the right hand side) mentioning this assay.
What is known about validated of test methods targeting Embryotoxicity?
Such information oftentimes is not provided for in published peer review articles that can be retrieved via Medline or Toxnet. Go3R Web closes this information gap. Go3R web is a Google Custom search interface which builds on the Go3R background knowledge and helps find information published on websites known to be relevant for the 3Rs and the validation and regulatory acceptance of toxicological test methods. Go3R web can be accessed via the button right above the search field on the right hand side of the Go3R website.
Where do publications that mention the Local Lymph Node Assay (LLNA) come from?
Go3R provides the user with a number of different statistics. In this example, you can see a list of countries and cities extracted from the affiliations for the 548 articles mentioning the LLNA
Who collaborates in your field?
The authors’ network for publications on the Local Lymph Node Assay reveals four groups that publish together.
Do you know your field? See who publishes the most and which are the journals to monitor?
For each search result, Go3R calculates the full statistics. See the Journals, Author, Cities, Countries, and the most frequent terms mentioned.
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