The MYC-WDR5 Nexus and Cancer.
Nashville, United States. In Cancer Res, Nov 2015
Recently, we discovered that recognition of target genes by MYC also depends on its interaction with WDR5, a WD40-repeat protein that exists as part of several chromatin-regulatory complexes.
Biophysical regulation of epigenetic state and cell reprogramming.
San Francisco, United States. In Nat Mater, 2013
Specifically, decreased histone deacetylase activity and upregulation of the expression of WD repeat domain 5 (WDR5)--a subunit of H3 methyltranferase--by microgrooved surfaces lead to increased histone H3 acetylation and methylation.
On WD40 proteins: propelling our knowledge of transcriptional control?
Singapore, Singapore. In Epigenetics, 2012
We will discuss how WDR5, a classical seven-bladed WD40 propeller, is able to bind with similar affinities both the catalytic subunit of the Trithorax-like complexes, and the histone H3 tail either unmodified or symmetrically dimethylated on arginine 2 (H3R2me2s).
WRAD: enabler of the SET1-family of H3K4 methyltransferases.
United States. In Brief Funct Genomics, 2012
Unlike most lysine methyltransferases, SET1-family enzymes are only fully active in the context of a multi-subunit complex, which includes a protein module comprised of WDR5, RbBP5, ASH2L and DPY-30 (WRAD).