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WD repeat domain 12

WDR12
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: Pes1, V1a, CAN, PCSK9, Flamingo
Papers on WDR12
The Crystal Structure of the Ubiquitin-like Domain of Ribosome Assembly Factor Ytm1 and Characterization of Its Interaction with the AAA-ATPase Midasin.
New
Stanley et al., United States. In J Biol Chem, Feb 2016
Midasin contains a C-terminal metal ion-dependent adhesion site (MIDAS) domain that interacts with the N-terminal ubiquitin-like (UBL) domain of Ytm1/WDR12 as well as the UBL domain of Rsa4/Nle1 in a later step in the ribosome maturation pathway.
Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.
New
Sinning et al., Heidelberg, Germany. In Nucleic Acids Res, Jan 2016
Among these factors is the conserved hetero-trimeric Nop7-Erb1-Ytm1 complex (or human Pes1-Bop1-Wdr12), which is removed from the evolving pre-60S particle by the AAA ATPase Rea1 to allow progression in the pathway.
Association Between Coronary Artery Disease Genetic Variants and Subclinical Atherosclerosis: An Association Study and Meta-analysis.
New
Elosua et al., Girona, Spain. In Rev Esp Cardiol (engl), Oct 2015
whereas the rs6725887 (WDR12; n = 7801) risk allele was inversely associated with this thickness (β = -0.013;
DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.
New
Eick et al., München, Germany. In Exp Cell Res, Jun 2015
PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs.
Comparative genomic approach reveals novel conserved microRNAs in Inner Mongolia cashmere goat skin and longissimus dorsi.
New
Zhang et al., Hohhot, China. In Mol Biol Rep, May 2015
WDR12 and CSNK1A1 involved in Notch/Wnt signal transduction pathway were finally identified.
Transcriptional regulation and functional involvement of the Arabidopsis pescadillo ortholog AtPES in root development.
Haralampidis et al., Athens, Greece. In Plant Sci, 2014
Yeast two hybrid and BiFC experiments confirmed that AtPES interacts physically with AtPEIP1 and AtPEIP2, the orthologs of the murine Bop1 and WDR12.
Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients.
Mafi Golchin et al., Tehrān, Iran. In Int J Mol Cell Med, 2014
In this study, a novel SNP (rs6725887) in the WD Repeat Protein 12 (WDR12) gene was selected to be examined in Iranian patients with CAD.
WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.
Ruskoaho et al., Oulu, Finland. In Plos One, 2014
AIMS: In a recent genome-wide association study, WD-repeat domain 12 (WDR12) was associated with early-onset myocardial infarction (MI).
Pescadillo plays an essential role in plant cell growth and survival by modulating ribosome biogenesis.
Pai et al., Seoul, South Korea. In Plant J, 2013
PES interacts with plant homologs of BOP1 and WDR12 in the nucleolus, which are also nucleolar proteins involved in ribosome biogenesis of yeast and mammals.
Genomic signatures of a global fitness index in a multi-ethnic cohort of women.
Goldschmidt-Clermont et al., Miami, United States. In Ann Hum Genet, 2013
TIGD7, UQCRH, PSMA6, WDR12, TFB2M, USP15) have previously reported associations with fitness-related phenotypes.
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.
Runz et al., Heidelberg, Germany. In Plos Genet, 2012
CXCL12, FAM174A, PAFAH1B1, SEZ6L, TBL2, WDR12) that knockdown correlates with altered LDL-receptor levels and/or that overexpression as GFP-tagged fusion proteins inversely modifies cellular cholesterol levels.
Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney.
Yasutake et al., Japan. In J Toxicol Sci, 2011
Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the cerebellum, increase the expression of 2 genes (Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
Large scale association analysis identifies three susceptibility loci for coronary artery disease.
FGENTCARD consortium et al., Beirut, Lebanon. In Plos One, 2010
We have used our Lebanese cohort to perform a replication study of nine previously identified CAD/MI susceptibility loci (LTA, CDKN2A-CDKN2B, CELSR2-PSRC1-SORT1, CXCL12, MTHFD1L, WDR12, PCSK9, SH2B3, and SLC22A3), and 88 genes in related phenotypes.
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Impact
Altshuler et al., Boston, United States. In Nat Genet, 2009
SNPs at nine loci reached genome-wide significance: three are newly identified (21q22 near MRPS6-SLC5A3-KCNE2, 6p24 in PHACTR1 and 2q33 in WDR12) and six replicated prior observations (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9).
Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.
GeneRIF
Eick et al., München, Germany. In Mol Cell Biol, 2007
Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association.
Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.
GeneRIF
Eick et al., München, Germany. In J Cell Biol, 2005
WDR12 triggers accumulation of p53 in a p19ARF-independent manner in proliferating cells but not in quiescent cells.
Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain.
GeneRIF
Ferrier et al., Marseille, France. In Genomics, 2002
Amino-terminal similarity to Notchless WD repeat protein. May function in the modulation of Notch signaling activity.
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