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WD repeat domain 33

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD
Papers on WDC146
A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner.
Shimizu et al., Okayama, Japan. In Biochem Biophys Res Commun, 2001
As the predicted size of the protein was 146 kDa, the gene was named WDC146.
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