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WW domain binding protein 1

WBP-1
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: YAP, WBP-2, Src, p53, Rsp5
Papers on WBP-1
Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
GeneRIF
Farooq et al., Miami, United States. In Biochemistry, 2011
The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP1 and WBP2 in a highly promiscuous and subtle manner.
Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1.
GeneRIF
Nakano et al., Wako, Japan. In J Biol Chem, 2011
Mcl-1 is a determinant of cell fate, and ATF6 mediates apoptosis via specific suppression of Mcl-1 through up-regulation of WBP1
Identification of novel human WW domain-containing proteins by cloning of ligand targets.
Fowlkes et al., Princeton, United States. In J Biol Chem, 1997
Two putative ligands of YAP, termed WBP-1 and WBP-2, have been found previously to contain several short peptide regions consisting of PPPPY residues (PY motif) that mediate binding to the WW domain of YAP.
Using molecular repertoires to identify high-affinity peptide ligands of the WW domain of human and mouse YAP.
Sudol et al., New York City, United States. In Biol Chem, 1997
One of the first WW domain-ligand links that was characterized in vitro was the WW domain of Yes-Associated Protein (YAP) and its WBP-1 ligand.
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.
Sudol et al., New York City, United States. In Proc Natl Acad Sci U S A, 1995
Using a functional screen of a cDNA expression library, we have identified two putative ligands of the WW domain of YAP, which we named WBP-1 and WBP-2.
Characterization of a novel protein-binding module--the WW domain.
Review
Bork et al., New York City, United States. In Febs Lett, 1995
Using a functional screen of a cDNA expression library, we have identified two putative ligands of the WW domain of YAP which we named WBP-1 and WBP-2.
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