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WAS protein family, member 3

WAVE3, WASF3, Brush-1
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, WAVE, Wasp, Arp2, HAD
Papers on WAVE3
Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion.
New
Cowell et al., United States. In Cancer Res, Jan 2016
UNASSIGNED: Activation of the WASF3 protein by extracellular stimuli promotes actin cytoskeleton reorganization and facilitates cancer cell invasion, whereas WASF3 depletion suppresses invasion and metastasis.
Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein.
New
Cowell et al., Augusta, United States. In Oncogene, Apr 2015
Using a mass spectrometry approach we have demonstrated that ATAD3A interacts with the WASF3 metastasis-promoting protein.
MiR-200b modulates the properties of human monocyte-derived dendritic cells by targeting WASF3.
New
Shao et al., Beijing, China. In Life Sci, Mar 2015
Protein expression of WASF3 was determined by Western blot and immunohistochemistry. Human peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Hypaque density gradient centrifugation from the buffy coat fraction of anticoagulated blood.
Overexpression of WAVE3 promotes tumor invasiveness and confers an unfavorable prognosis in human hepatocellular carcinoma.
New
Zhang et al., Beijing, China. In Biomed Pharmacother, Feb 2015
The aim of this study was to investigate the effect of WAVE3 on the behaviors of HCC cells and to evaluate its clinical impact.
Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cells.
Jiang et al., Cardiff, United Kingdom. In Cancer Cell Int, 2014
WAVE-3 has exhibited an association with disease progression and poorer prognosis of certain malignancies.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail.
Jianbo et al., Zhengzhou, China. In Cancer Gene Ther, 2014
WAVE3, an actin cytoskeleton remodeling protein overexpressed in many kinds of cancers, has been associated with a lot of metastatic diseases.
Expression of WASF3 in patients with non-small cell lung cancer: Correlation with clinicopathological features and prognosis.
Xue et al., Jinzhou, China. In Oncol Lett, 2014
Wiskott-Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer.
The involvement of JAK-STAT3 in cell motility, invasion, and metastasis.
Review
Cowell et al., Augusta, United States. In Jakstat, 2014
JAK-STAT3 signaling, while regulating many aspects of cancer development and progression, promotes invasion and metastasis through activation of key metastasis promoting genes such as WASF3.
IL-17A regulates Eimeria tenella schizont maturation and migration in avian coccidiosis.
Sánchez-Acedo et al., Zaragoza, Spain. In Vet Res, 2013
Finally, schizonts from untreated and infected chickens expressed S100, Wiskott-Aldrich syndrome protein family member 3 (WASF3), and heat shock protein-70 (HSP70) proteins as merozoites matured, whereas the expression of these proteins was absent in IL17A Ab-treated chickens.
Loss of WAVE3 sensitizes triple-negative breast cancers to chemotherapeutics by inhibiting the STAT-HIF-1α-mediated angiogenesis.
Sossey-Alaoui et al., Cleveland, United States. In Jakstat, 2013
WAVE3 is an actin-cytoskeleton remodeling protein, and recent studies have highlighted a potential role for WAVE3 in promoting tumor progression and metastasis in TNBC.
WAVE3-NFκB interplay is essential for the survival and invasion of cancer cells.
Sossey-Alaoui et al., Cleveland, United States. In Plos One, 2013
The WAVE3 cytoskeletal protein promotes cancer invasion and metastasis.
MicroRNA-217 regulates WASF3 expression and suppresses tumor growth and metastasis in osteosarcoma.
Li et al., Qiqihar, China. In Plos One, 2013
Moreover, we identified WASF3 as a novel functional downstream target of miR-217.
Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasis.
Review
Sossey-Alaoui, Cleveland, United States. In Semin Cell Dev Biol, 2013
WAVE3 belongs to the WASP/WAVE family of actin cytoskeleton remodeling proteins.
HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein.
GeneRIF
Cowell et al., Augusta, United States. In J Biol Chem, 2012
HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein.
Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.
GeneRIF
Cowell et al., Augusta, United States. In Int J Cancer, 2012
coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-kappaB signaling, which in turn regulates MMP-9 production facilitating invasion.
WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade.
GeneRIF
Plow et al., Cleveland, United States. In Int J Cancer, 2011
The study also identifies a critical role for WAVE3, downstream of miR-31, in the invasion-metastasis cascade.
WAVE3 is associated with invasiveness in prostate cancer cells.
GeneRIF
Jiang et al., Cardiff, United Kingdom. In Urol Oncol, 2010
WAVE3 is pivotal in controlling the invasiveness of prostate cancer cells.
The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.
GeneRIF
Plow et al., Cleveland, United States. In J Biol Chem, 2009
Studies identified a novel mechanism for the regulation of WAVE3 expression in cancer cells, which controls the invasive properties and morphology of cancer cells associated with their metastatic potential.
WAVE signalling: from biochemistry to biology.
Review
Scott et al., Portland, United States. In Biochem Soc Trans, 2006
One group of Rho GTPase effectors, WAVE (Wiskott-Aldrich syndrome protein verprolin homologous)-1, WAVE-2 and WAVE-3, function as scaffolds for actin-based signalling complexes.
WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.
Review
Miki et al., Tokyo, Japan. In J Cell Sci, 2001
Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1, WAVE2 and WAVE3 have been shown to regulate cortical actin filament reorganization in response to extracellular stimuli.
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