Decreased expression of cortactin in the schizophrenia brain.
New York City, United States. In Neuroreport, Jan 2016
To determine whether the Arp2/3 complex is abnormally expressed in schizophrenia, we measured the protein expression of Arp2 and Arp3, as well as Arp2/3 complex binding partners and associated proteins including cortactin, neuronal-Wiskott-Aldrich syndrome protein (WASP), WASP-family verprolin homologous protein 1 (WAVE1), and Abelson interactor 1 (Abi1) in the superior temporal gyrus of paired schizophrenia and comparison participants.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
New York City, United States. In Nat Med, Sep 2015
Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1 or WASF1) as part of a negative feedback mechanism to limit Aβ production.
Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases.
Philadelphia, United States. In Gene, Sep 2015
Downstream, NEDD9 regulation of partners including CRKL, WAVE, PI3K/AKT, ERK, E-cadherin, Aurora-A (AURKA), HDAC6, and others allow NEDD9 to influence functions as pleiotropic as migration, invasion, survival, ciliary resorption, and mitosis.
Signaling networks that regulate cell migration.
Charlottesville, United States. In Cold Spring Harb Perspect Biol, Aug 2015
Their effectors include actin regulators such as formins, members of the WASP/WAVE family and the Arp2/3 complex, and the myosin II motor protein.
MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion.
Leuven, Belgium. In J Chem Theory Comput, Aug 2015
Cytoplasmic FMRP interacting protein 1 (CYFIP1), also known as specifically RAC1 activated protein 1 (Sra1), plays a dual role: together with fragile X mental retardation protein (FMRP) and eIF4E it forms a complex that inhibits mRNA translation, while together with WAVE1, NCKAP1, ABI2, and HSPC300 it forms the WAVE regulatory complex (WRC) that upon RAC1 activation initiates actin polymerization.
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.
Gif-sur-Yvette, France. In Nat Rev Mol Cell Biol, 2014
Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration.