Decreased expression of cortactin in the schizophrenia brain.
New York City, United States. In Neuroreport, Jan 2016
To determine whether the Arp2/3 complex is abnormally expressed in schizophrenia, we measured the protein expression of Arp2 and Arp3, as well as Arp2/3 complex binding partners and associated proteins including cortactin, neuronal-Wiskott-Aldrich syndrome protein (WASP), WASP-family verprolin homologous protein 1 (WAVE1), and Abelson interactor 1 (Abi1) in the superior temporal gyrus of paired schizophrenia and comparison participants.
APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
New York City, United States. In Nat Med, Sep 2015
Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1 or WASF1) as part of a negative feedback mechanism to limit Aβ production.
Signaling networks that regulate cell migration.
Charlottesville, United States. In Cold Spring Harb Perspect Biol, Aug 2015
Their effectors include actin regulators such as formins, members of the WASP/WAVE family and the Arp2/3 complex, and the myosin II motor protein.
A role for the small GTPase Rac1 in vaccinia actin-based motility.
Buenos Aires, Argentina. In Small Gtpases, 2014
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell.
Capping protein regulators fine-tune actin assembly dynamics.
Saint Louis, United States. In Nat Rev Mol Cell Biol, 2014
These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.
Gif-sur-Yvette, France. In Nat Rev Mol Cell Biol, 2014
Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration.