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LATS, large tumor suppressor, homolog 1

Warts
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, YAP, AGE, V1a
Papers on Warts
Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial.
New
Bhat et al., Wardha, India. In Indian J Dermatol Venereol Leprol, Jan 2016
BACKGROUND: Warts are known to clear spontaneously with the development of cell-mediated immunity (CMI) to the virus.
Warts Opens Up for Activation.
New
Harvey et al., Melbourne, Australia. In Dev Cell, Jan 2016
Warts is the central effector kinase of the Hippo growth-control pathway.
Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts.
New
Struhl et al., New York City, United States. In Dev Cell, Jan 2016
Specifically, we show that activity of the Drosophila NDR kinase Warts in the developing wing depends on its transition from an inactive, "closed" conformation to a potentially active, "open" conformation mediated by Mats, a conserved Mps1-binder (Mob) protein.
The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.
New
Gong et al., Tianjin, China. In J Exp Bot, Jan 2016
Central to this pathway is a kinase cascade composed of Hippo and Warts, and their activating partners Salvador and Mob1/Mats.
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
Wang et al., T'ai-chung-shih, Taiwan. In Plos One, 2014
Human mesenchymal stem cells (MSCs) modified by targeting DNA hypermethylation of genes in the Salvador/Warts/Hippo pathway were induced to differentiate into neuronal cells in vitro.
Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.
Impact
Irvine et al., United States. In Cell, 2014
The influence of myosin activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative regulator of Warts within the Hippo pathway.
Genetics on a WHIM.
Review
Wetzler et al., Buffalo, United States. In Br J Haematol, 2014
We initially described the WHIM syndrome based on the combination of Warts, Hypogammaglobulinaemia, Infections and Myelokathexis (neutrophil retention in the bone marrow).
[Role of the Hippo pathway in cell proliferation and organ size control. Disorders of the pathway in cancer diseases].
Review
Kmieć et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2013
The Hippo pathway (also known as SWH--Salvador/Warts/Hippo), discovered for the first time in Drosophila melanogaster, is responsible for cell proliferation and organ size control in mammalian systems.
Opposite feedbacks in the Hippo pathway for growth control and neural fate.
Impact
Cook et al., New York City, United States. In Science, 2013
In the Drosophila eye, cross-repression between the Hippo pathway kinase LATS/Warts (Wts) and growth regulator Melted generates mutually exclusive photoreceptor subtypes.
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
Impact
Harvey et al., Melbourne, Australia. In Nat Cell Biol, 2013
Signalling from the FtICD is well characterized and controls tissue growth by regulating the abundance of the Yki-repressive kinase Warts (Wts).
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Impact
Tapon et al., London, United Kingdom. In Nat Cell Biol, 2013
The pathway core is a kinase cassette, comprising the kinases Hpo and Warts (Wts) and the scaffold proteins Salvador (Sav) and Mats, which inactivates the pro-growth transcriptional co-activator Yorkie (Yki).
Warts and all: human papillomavirus in primary immunodeficiencies.
Review
Holland et al., Bethesda, United States. In J Allergy Clin Immunol, 2012
Infection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy.
Protein kinases of the Hippo pathway: regulation and substrates.
Review
Barrufet et al., Boston, United States. In Semin Cell Dev Biol, 2012
The core pathway components are the GC kinase Hippo, which phosphorylates the noncatalytic polypeptide Mats/Mob1 and, with the assistance of the scaffold protein Salvador, phosphorylates the ndr-family kinase Lats.
LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.
GeneRIF
Kuninaka et al., Tokyo, Japan. In J Cell Biol, 2012
LATS1 phosphorylates a phosphatase as does the yeast Dbf2 and demonstrate a novel role of LATS1 in controlling PLK1 at the G2 DNA damage checkpoint.
Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions.
Review
Hergovich, London, United Kingdom. In Biochem Soc Trans, 2012
Finally, the kinase activities of LATS1/2 (large tumour-suppressor kinase 1/2), the human counterparts of Warts, are controlled by binding to hMOB1 (human Mps one binder protein 1), the human Mats.
LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.
GeneRIF
Yang et al., In Cell Res, 2011
LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization.
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements.
Impact
Knoblich et al., Vienna, Austria. In Nat Cell Biol, 2011
We demonstrate that brain tumours in l(3)mbt mutants originate from overproliferation of neuroepithelial cells in the optic lobes caused by derepression of target genes in the Salvador-Warts-Hippo (SWH) pathway.
Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected].
GeneRIF
Yang et al., Kingston, Canada. In Proc Natl Acad Sci U S A, 2011
study identifies E3 ubiquitin ligase Itch as a unique negative regulator of LATS1 and presents a possibility of targeting LATS1/Itch interaction as a therapeutic strategy in cancer.
KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.
GeneRIF
Dong et al., Omaha, United States. In J Biol Chem, 2011
KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif
Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity.
GeneRIF
Aqeilan et al., Jerusalem, Israel. In Cancer Res, 2011
ubiquitin E3 ligase ITCH physically and functionally associates with LATS1
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