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Calcium channel, voltage-dependent, gamma subunit 2

WAG, Stargazin, Cacng2
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: WAVE, AGE, HAD, CAN, ACID
Papers on WAG
The Modulatory Effect of Metabotropic Glutamate Receptor Type-1α on Spike-Wave Discharges in WAG/Rij Rats.
Gorji et al., Tehrān, Iran. In Mol Neurobiol, Feb 2016
In this study, the expression of mGlu1α receptors in the thalamic nuclei was assessed during development of absence seizures in the WAG/Rij rats, a valid genetic animal model of absence epilepsy.
SPECT of Transplanted Islets of Langerhans by Dopamine 2 Receptor Targeting in a Rat Model.
Gotthardt et al., Nijmegen, Netherlands. In Mol Pharm, Feb 2016
Subsequently, 1,000 islets were transplanted in the calf muscle of WAG/Rij rats and SPECT/CT images were acquired 6 weeks after transplantation.
Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy.
Shuba et al., Kiev, Ukraine. In Epilepsy Res, Jan 2016
In humans, absences accompany only childhood or adolescent epileptic syndromes-though in its polygenic rat models WAG/Rij and GAERS the opposite developmental pattern is observed.
Molecular cloning, characterization and expression analysis of WAG-1 in the pistillody line of common wheat.
Peng et al., Nanchong, China. In Genet Mol Res, 2014
Wheat WAG-1 is a C-class MADS-box gene, which is orthologous to AGAMOUS in Arabidopsis.
A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.
Athey et al., Ann Arbor, United States. In Pharmacogenomics, 2014
They were located within noncoding regions of ten genes: ANK3, ARNTL, CACNA1C, CACNG2, CDKN1A, CREB1, GRIA2, GSK3B, NR1D1 and SLC1A2.
A current perspective on the role of AGCVIII kinases in PIN-mediated apical hook development.
Chory et al., Los Angeles, United States. In Front Plant Sci, 2014
Their localization and activity are regulated by two subfamilies of AGCVIII protein kinases: the D6 PROTEIN KINASEs as well as PINOID and its two closely related WAG kinases.
Chastikin et al., In Morfologiia, 2014
The effects of the injection of autologous multipotent stromal stem cells of bone marrow origin (MSSCBM) (mesenchymal stem cells) with green fluorescent protein gene, additionally marked with DAPI nuclear stain, close to a thrombosed hindlimb vein, were studied by fluorescent microscopy in adult male Wag rats (n = 214).
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
Decher et al., Marburg an der Lahn, Germany. In Front Mol Neurosci, 2014
Rats of the Wistar Albino Glaxo/Rij (WAG/Rij) strain show symptoms resembling human absence epilepsy.
From mouse to humans: discovery of the CACNG2 pain susceptibility gene.
Nissenbaum, Jerusalem, Israel. In Clin Genet, 2012
This integrated approach has led to identification of CACNG2 as a novel neuropathic pain gene affecting pain susceptibility both in mice and humans.
Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice.
Huguenard et al., Stanford, United States. In J Neurosci, 2012
This study suggested that, in stg, a trafficking defect in synaptic AMPARs in RTN cells leads to a compensatory increase in synaptic NMDARs and enhanced thalamic excitability.
Channel properties reveal differential expression of TARPed and TARPless AMPARs in stargazer neurons.
Cull-Candy et al., London, United Kingdom. In Nat Neurosci, 2012
the loss of gamma-2 in stargazer mouse stellate cells induces changes in synaptic transmission that cannot be compensated for by the remaining TARP gamma-7.
Regulation of AMPA receptor surface diffusion by PSD-95 slots.
Choquet et al., Bordeaux, France. In Curr Opin Neurobiol, 2012
Recent studies have identified the interaction between the AMPAR-Stargazin complex and PSD-95 as the minimal components of the diffusional trapping slot.
Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells.
Yuzaki et al., Tokyo, Japan. In Eur J Neurosci, 2012
Results indicate that hippocampal and cerebellar long-term depression share a common pathway, namely dephosphorylation of stargazin by calcineurin.
Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse.
Leitch et al., Dunedin, New Zealand. In Brain Res, 2012
Ataxic phenotype in stargazers is primarily due to absence of AMPA receptors at cerebellar mossy-fiber-granule cell synapses.
Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures.
Powell et al., Melbourne, Australia. In Neurosci Lett, 2011
Two rat models of IGE with absence seizures, the Genetic Epilepsy Rats from Strasbourg (GAERS) and Wistar Albino Glaxo from Rijswijk (WAG/Rij), have proven valuable for translational research.
Two modes of interaction between the membrane-embedded TARP stargazin's C-terminal domain and the bilayer visualized by electron crystallography.
Unger et al., New Haven, United States. In J Struct Biol, 2011
Data suggest that stargazin interactions with and within the membrane play significant roles in TARP structure and directly visualize TARP functional mechanisms essential for AMPAR trafficking and clustering.
Stargazin modulates AMPA receptor gating and trafficking by distinct domains.
Bredt et al., In Nature, 2005
Here, we find that the AMPA receptor interacting protein, stargazin, not only mediates AMPA receptor trafficking but also shapes synaptic responses by slowing channel deactivation and desensitization.
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.
Nicoll et al., San Francisco, United States. In Nature, 2001
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells.
The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.
Frankel et al., Bar Harbor, United States. In Nat Genet, 1998
We describe here a novel gene, Cacng2, whose expression is disrupted in two stargazer alleles.
Neurobiology of Depression as a Comorbidity of Epilepsy
Mazarati et al., Bethesda, United States. In Unknown Journal, 0001
Depression-like behaviors of despair (immobility in the forced swim test) and anhedonia (loss of preference for sweetened water) have been described in the generalized spike-wave epilepsy model involving the WAG/Rij strain of rats as well as models of limbic epilepsy.
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