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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Visual system homeobox 1 homolog

Vsx1
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Top mentioned proteins: CAN, Chx10, SOD, HAD, ZEB1
Papers on Vsx1
Molecular Screening of Keratoconus Susceptibility Sequence Variants in VSX1, TGFBI, DOCK9, STK24, and IPO5 Genes in Polish Patients and Novel TGFBI Variant Identification.
New
Gajecka et al., Poznań, Poland. In Ophthalmic Genet, Sep 2015
The purpose of our study was to verify the role of VSX1, TGFBI, DOCK9, IPO5, and STK24 sequence variants in Polish KTCN patients.
Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
New
Wang et al., Qingdao, China. In Ophthalmic Genet, Jun 2015
SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC.
Polymorphism Analysis of VSX1 and SOD1 Genes in Greek Patients with Keratoconus.
Ladas et al., In Ophthalmic Genet, 2014
BACKGROUND: A number of mutations in the VSX1 and SOD1 genes have been reported to be associated with keratoconus (KC), however the results from different studies are controversial.
The uniform-score gene set analysis for identifying common pathways associated with different diabetes traits.
Mosley et al., Jackson, United States. In Bmc Genomics, 2014
The study identified 7 gene sets that contain binding motifs at promoter region of component genes for 5 transcription factors (TFs) of FOXO4, TCF3, NFAT, VSX1 and POU2F1, and 1 microRNA of mir-218.
MicroRNA-20a is essential for normal embryogenesis by targeting vsx1 mRNA in fish.
Luo et al., Hangzhou, China. In Rna Biol, 2014
Here we show that miR-20a can target the mRNA of vsx1, a multiple functional gene, at the 3'-UTR and inhibit protein expression in both goldfish and zebrafish.
Two novel missense substitutions in the VSX1 gene: clinical and genetic analysis of families with Keratoconus from India.
Nallathambi et al., Bengaluru, India. In Bmc Med Genet, 2014
BACKGROUND: Visual system homeobox gene (VSX1) plays a major role in the early development of craniofacial and ocular tissues including cone opsin gene in the human retina.
Maternal Vsx1 plays an essential role in regulating prechordal mesendoderm and forebrain formation in zebrafish.
Luo et al., Hangzhou, China. In Dev Biol, 2014
Here we show that in zebrafish a maternal transcription repressor Vsx1 is essential for this early developmental regulation.
Maternal control of axial-paraxial mesoderm patterning via direct transcriptional repression in zebrafish.
Luo et al., Hangzhou, China. In Dev Biol, 2014
Loss- and gain-of-function experiments showed that a maternal transcription factor Vsx1 is essential for restricting flh expression within the dorsal margin and preserving spt expression and paraxial mesoderm specification in the ventrolateral margin of embryo.
Genetics of the corneal endothelial dystrophies: an evidence-based review.
Review
Frausto et al., Los Angeles, United States. In Clin Genet, 2013
Mutations in several genes have been implicated as playing a pathogenic role in the corneal endothelial dystrophies: VSX1 mutations in PPCD1; COL8A2 mutations in PPCD2 and FECD; ZEB1 mutations in PPCD3 and FECD; and SLC4A11 mutations in CHED2 and FECD.
Insights into keratoconus from a genetic perspective.
Review
Vincent et al., Adelaide, Australia. In Clin Exp Optom, 2013
VSX1 remains as the best characterised keratoconus gene but only accounts for rare cases.
Using bovine pituitary extract to increase proliferation of keratocytes and maintain their phenotype in vitro.
Wang et al., Zhengzhou, China. In Int J Ophthalmol, 2012
The phenotypes and proliferation of cultured cells were evaluated by morphology, immunofluorescent staining and mRNA expression of CD34, Lumican, VSX1, α-SMA and proliferating cell nuclear antigen (PCNA).
Study of VSX1 mutations in patients with keratoconus in southwest Iran using PCR-single-strand conformation polymorphism/heteroduplex analysis and sequencing method.
Chaleshtori et al., Sārī, Iran. In Acta Cytol, 2012
Many genes are involved in the disease, but evidence suggests a major role for VSX1 in the etiology of KC.
The Genetics of Keratoconus: A Review.
Liu et al., Durham, United States. In Reprod Syst Sex Disord, 2012
The genes implicated potentially include VSX1, miR-184, DOCK9, SOD1, RAB3GAP1, and HGF.
Review: keratoconus in Asia.
Review
Loon et al., Singapore, Singapore. In Cornea, 2012
Genetic and disease risk factors include atopy, vernal keratoconjunctivitis, Down syndrome, pellucid marginal corneal degeneration, VSX1 (visual system homeobox 1) gene, and Leber congenital amaurosis.
Requirement for the paired-like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation.
GeneRIF
Chow et al., Victoria, Canada. In J Comp Neurol, 2012
These findings reveal a role for Vsx1 in type 3a bipolar cells and suggest that Vsx1 function is required transiently in this cell type during the postnatal period.
Vsx1 regulates terminal differentiation of type 7 ON bipolar cells.
GeneRIF
Chow et al., Victoria, Canada. In J Neurosci, 2011
findings indicate that Vsx1 regulates terminal gene expression in Type 7 bipolar cells and is necessary for proper ON visual signaling within a directionally selective circuit.
Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina.
GeneRIF
Wong et al., Saint Louis, United States. In J Neurosci, 2008
Transcription factor visual system homeobox 1 homolog (Vsx1) controls specific aspects of visual function in the neural circuitry of the mammalian retina.
Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.
GeneRIF
Levine et al., Salt Lake City, United States. In Brain Res, 2008
Although Vsx1 mRNA is upregulated in Chx10/Vsx2 deficient RPCs, Vsx1 does not genetically compensate for loss of Chx10/Vsx2, demonstrating that Prd-L:CVC genes, although important, are not absolutely required to initiate retinal development.
[Keratoconus: epidemiology, risk factors and diagnosis].
Review
Duncker et al., Halle, Germany. In Klin Monbl Augenheilkd, 2006
In some patients heterozygous mutations in the VSX1 gene are described as the underlying gene defect.
Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1.
GeneRIF
Behringer et al., Houston, United States. In Curr Biol, 2004
Vsx1 is required for cone bipolar cell differentiation and regulates photopic vision perception.
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