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Vaccinia related kinase 2

VRK2, Vaccinia-related kinase-2
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, leukocytes, fetal liver, and carcinomas. Its protein localizes to the endoplasmic reticulum and has been shown to phosphorylate casein and undergo autophosphorylation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, VRK1, MAPK, p53, HAD
Papers on VRK2
Vaccinia-Related Kinase 2 Controls the Stability of the Eukaryotic Chaperonin TRiC/CCT by Inhibiting the Deubiquitinating Enzyme USP25.
Kim et al., South Korea. In Mol Cell Biol, May 2015
We have previously shown that vaccinia-related kinase 2 (VRK2) downregulates TRiC protein levels through the ubiquitin-proteasome system by recruiting the E3 ligase COP1.
[Replicative study of susceptibility to childhood-onset schizophrenia in Kazakhs].
Svyatova et al., In Genetika, Feb 2015
An association of early-onset schizophrenia with genetic markers in three genes (VRK2, KCNB2, and CPVL) was found.
Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population.
Li et al., Xi'an, China. In Genet Mol Res, 2014
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population.
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.
International League Against Epilepsy Consortium on Complex Epilepsies. Electronic address:, In Lancet Neurol, 2014
For the cohort of genetic generalised epilepsy, we noted a single signal at 2p16.1 (p=9·99 × 10(-9)), implicating VRK2 or FANCL.
Vaccinia-related kinase 2 mediates accumulation of polyglutamine aggregates via negative regulation of the chaperonin TRiC.
Kim et al., South Korea. In Mol Cell Biol, 2014
Here, we propose that vaccinia-related kinase 2 (VRK2) is a critical enzyme that negatively regulates TRiC.
Effects of VRK2 (rs2312147) on white matter connectivity in patients with schizophrenia.
Lee et al., South Korea. In Plos One, 2013
Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2), in multiple Asian and European samples.
Genetics of the epilepsies: where are we and where are we going?
Lowenstein et al., Kiel, Germany. In Curr Opin Neurol, 2013
A genome-wide association study in idiopathic generalized epilepsy revealed the first common risk variants for human seizure disorders including variants in VRK2, PNPO and SCN1A.
Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals.
Lazo et al., Lugo, Spain. In J Biol Inorg Chem, 2013
The human vaccinia-related kinase (VRK) proteins VRK1 and VRK2 regulate different processes, such as the cell cycle, DNA damage response, and signaling by mitogen-activated protein kinases in response to growth factors or cellular stress.
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.
Sander et al., Bonn, Germany. In Hum Mol Genet, 2013
The associated regions harbor high-ranking candidate genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32.
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
Lazo et al., Salamanca, Spain. In J Biol Chem, 2013
Human VRK2 (vaccinia-related kinase 2), a kinase that emerged late in evolution, affects different signaling pathways, and some carcinomas express high levels of VRK2.
Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility.
MooDS Consortium et al., Kunming, China. In Schizophr Res, 2012
Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10(-4),
Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways.
Nelson et al., Los Angeles, United States. In Front Psychiatry, 2012
Exome sequencing identified very rare, heterozygous, and likely protein-damaging variants in eight brain-expressed genes: IQUB, JMJD1C, GADD45A, GOLGB1, PLSCR5, VRK2, MESDC2, and FGGY.
Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulations.
Li et al., Dalian, China. In Curr Pharm Des, 2012
To study the underlying molecular mechanisms, molecular dynamics simulations were performed to investigate the role of bivalent cations Mg²⁺ and Mn²⁺ in the structural stabilities and dynamical behaviors of vaccinia related kinase 3 (VRK3), which was the first solved crystal structure of the pseudokinase, and that of its closest active relatives VRK1 and VRK2.
VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis.
Lazo et al., Salamanca, Spain. In Bmc Clin Pathol, 2012
METHODS AND RESULTS: VRK1 and VRK2 (Vaccinia-related kinase-1, -2) expression, as well as proliferation markers, were determined in a tissue microarray containing 105 primary astrocytoma biopsies.
Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression.
Lazo et al., Salamanca, Spain. In Cell Death Dis, 2012
VRK2 is a novel Ser-Thr kinase whose VRK2A isoform is located in the endoplasmic reticulum and mitochondrial membranes.
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
Stefansson et al., Reykjavík, Iceland. In Hum Mol Genet, 2011
Common variants at VRK2 show genome-wide significant association with schizophrenia.
VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.
Lazo et al., Salamanca, Spain. In Mol Cell Biol, 2010
Data suggest a role for VRK2A in ErbB2-MAPK signaling.
Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities.
Lazo et al., Salamanca, Spain. In Mol Cell Proteomics, 2008
Ran is a novel negative regulator of nuclear VRK1 and VRK2 kinase activity, which may vary in different subcellular localizations generating an asymmetric intracellular distribution of kinase activity depending on local protein interactions.
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Lazo et al., Salamanca, Spain. In Plos One, 2007
the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta
The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.
Lazo et al., Salamanca, Spain. In Plos One, 2007
the downregulation of VRK2 protein levels, as a consequence of p53 accumulation, is thus dependent on the levels of the p300/CBP protein available for transcriptional complexes
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