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Vaccinia related kinase 1

VRK1, vaccinia-related kinase 1
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, p53, VRK2, Histone, mdm2
Papers on VRK1
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
New
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
In addition, our analysis showed protein kinases WNK1, LYN, VRK1, ABL1, CDK4, CDKL3, SgK223 and ADCK1, and protein phosphatases PTPRF, ACP1, DNAJC6, SSH2 and UBASH3B that have not been directly linked to fear memory processes so far.
Expanding Phenotype of VRK1 Mutations in Motor Neuron Disease.
New
Sheikh et al., Houston, United States. In J Clin Neuromuscul Dis, Dec 2015
Through whole-exome sequencing, a VRK1 mutation was identified.
High VRK1 expression contributes to cell proliferation and survival in hepatocellular carcinoma.
New
Wan et al., Nantong, China. In Pathol Res Pract, Dec 2015
UNASSIGNED: VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases, which is known to play multiple roles in cellular proliferation, cell cycle regulation and carcinogenesis.
Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition.
New
Choi et al., South Korea. In Oncotarget, Nov 2015
We identified the specific role of vaccinia-related kinase 1 (VRK1) in the progression of hepatocellular carcinoma (HCC) and evaluated its therapeutic and prognostic potential.
Presumed pseudokinase VRK3 functions as a BAF kinase.
New
Kim et al., South Korea. In Biochim Biophys Acta, Jul 2015
Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity.
Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.
New
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Jun 2015
In addition to association to certain MHC alleles and haplotypes, we identified 11 genes (WFDC3, HOMER2, VRK1, PTPN3, WHAMM, BANK1, AP3B2, DAPP1, LAMTOR3, DDIT4L and PPP3CA) located on five chromosomes that contain multiple risk haplotypes correlated with gene expression and disease sub-phenotypes in an intricate manner.
The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.
New
Levy-Lahad et al., Jerusalem, Israel. In J Neurosci, Feb 2015
We previously identified a nonsense mutation in Vaccinia-related kinase 1 (VRK1), R358X, as a cause of SMA-PCH.
Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.
Kim et al., South Korea. In Sci Rep, 2014
Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival.
VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle.
Lazo et al., Salamanca, Spain. In Sci Rep, 2014
The Ser-Thr VRK1 (vaccinia-related kinase 1) kinase, whose activity is also cell cycle regulated, interacts with and phosphorylates coilin regulating assembly of CBs.
VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage.
Lazo et al., Salamanca, Spain. In Epigenetics, 2014
In this work, we demonstrate that VRK1 is a nucleosomal chromatin kinase and that its depletion causes loss of histones H3 and H4 acetylation, which are required for chromatin relaxation, both in basal conditions and after DNA damage, independently of ATM.
EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.
Impact
Rivera et al., Boston, United States. In Cancer Cell, 2014
These divergent chromatin-remodeling patterns repress tumor suppressors and mesenchymal lineage regulators while activating oncogenes and potential therapeutic targets, such as the kinase VRK1.
A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds.
Kim et al., Ch'ŏngju, South Korea. In J Anim Sci Technol, 2013
Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1).
Role of bivalent cations in structural stabilities of new drug targets--vaccinia-related kinases (VRK) from molecular dynamics simulations.
Review
Li et al., Dalian, China. In Curr Pharm Des, 2012
To study the underlying molecular mechanisms, molecular dynamics simulations were performed to investigate the role of bivalent cations Mg²⁺ and Mn²⁺ in the structural stabilities and dynamical behaviors of vaccinia related kinase 3 (VRK3), which was the first solved crystal structure of the pseudokinase, and that of its closest active relatives VRK1 and VRK2.
Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.
GeneRIF
Lazo et al., Salamanca, Spain. In J Biol Chem, 2012
Data show that vaccinia-related kinase 1 (VRK1) in resting cells plays an important role in the formation of ionizing radiation-induced foci that assemble on the 53BP1 scaffold protein during the DNA damage response.
Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase.
GeneRIF
Kim et al., South Korea. In J Biol Chem, 2012
direct interaction and binding features between VRK1 and macroH2A1.2
Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications.
GeneRIF
Lazo et al., Salamanca, Spain. In J Proteomics, 2012
VRK1 interacts and phosphorylates coilin, a protein regulating the assembly of Cajal bodies in the nucleus.
Roles of VRK1 as a new player in the control of biological processes required for cell division.
Review
Lazo et al., Salamanca, Spain. In Cell Signal, 2011
VRK1 (Vaccinia-related kinase 1) is an early response gene required for cyclin D1 expression, regulates p53 by a specific Thr18 phosphorylation, controls chromatin condensation by histone phosphorylation, nuclear envelope assembly by phosphorylation of BANF1, and participates in signalling required for Golgi fragmentation late in the G2 phase.
NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity.
GeneRIF
Yoon et al., Singapore, Singapore. In J Biol Chem, 2011
NMR solution structure of a catalytically active form of human VRK1
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
GeneRIF
Lazo et al., Salamanca, Spain. In Plos One, 2010
VRK1 downregulation is necessary to modulate the block in cell cycle progression induced by p53 as part of its DNA damage response.
The genetics of spinal muscular atrophies.
Review
Sumner et al., Baltimore, United States. In Curr Opin Neurol, 2010
The genes associated with 14 of these disorders have been identified in the last decade, including four within the last year: TRPV4, ATP7A, VRK1, and HSPB3.
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