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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Charged multivesicular body protein 5

Vps60, Mos10, PNAS-2, CHMP5, Vps60p
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on Vps60
[Expression spectra of apoptosis-related gene pnas-2].
Ouyan et al., Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2008
pnas-2 is specifically up-regulated in acute leukemia patients.
[Correlation between expression of apoptosis-related gene pnas-2 and leukemia].
Chen et al., Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007
The pnas-2 gene may be closely related with apotosis of arsenic sulfide treated APL cells.
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Ghosh et al., New Haven, United States. In J Cell Biol, 2006
CHMP5 regulates late endosome function downstream of MVB formation, and the loss of CHMP5 enhances signal transduction by inhibiting lysosomal degradation of activated receptors.
PNAS-2: a novel gene probably participating in leukemogenesis.
Ouyang et al., Shanghai, China. In Oncology, 2005
PNAS-2 was shown to be anti-apoptotic and may participate in leukemogenesis
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