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VPS53 Vps53p

Vps53, Vps53p
This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: p180, ACID, Rab5, carboxypeptidase, STEP
Papers on Vps53
EARP is a multisubunit tethering complex involved in endocytic recycling.
New
Impact
Bonifacino et al., Bethesda, United States. In Nat Cell Biol, May 2015
The two complexes share the Ang2, Vps52 and Vps53 subunits, but EARP contains an uncharacterized protein, syndetin, in place of the Vps54 subunit of GARP.
The GARP complex is required for cellular sphingolipid homeostasis.
Walther et al., Boston, United States. In Elife, 2014
A GARP complex mutation analogous to a VPS53 allele causing progressive cerebello-cerebral atrophy type 2 (PCCA2) in humans exhibits similar, albeit weaker, phenotypes in yeast, providing mechanistic insights into disease pathogenesis.
VPS53 mutations cause progressive cerebello-cerebral atrophy type 2 (PCCA2).
Birk et al., Beersheba, Israel. In J Med Genet, 2014
Whole exome sequencing identified only two mutations within this locus, which were common to the affected individuals: compound heterozygous mutations in VPS53, segregating as expected for autosomal recessive heredity within all four families, and common in Moroccan Jews (∼1:37 carrier rate).
Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast.
Ohta et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
Deletion mutants of VPS51, VPS52, VPS53, and VPS54 encoding the components of Golgi-associated retrograde protein (GARP) complex, YPT6 encoding a Rab family small GTPase that functions with GARP complex, RIC1 and RGP1 encoding its guanine nucleotide exchange factor (GEF), and TLG2 encoding t-SNARE exhibited hypersensitivity to Ro.
The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.
Eimer et al., Göttingen, Germany. In Mol Biol Cell, 2011
It consists of four subunits--Vps51p, Vps52p, Vps53p, and Vps54p--and shares similarities with other multimeric tethering complexes, such as the conserved oligomeric Golgi (COG) and the exocyst complex.
Involvement of the Arabidopsis HIT1/AtVPS53 tethering protein homologue in the acclimation of the plasma membrane to heat stress.
Wu et al., Taiwan. In J Exp Bot, 2011
The HIT1 gene encodes a protein that is homologous to yeast Vps53p, which is a subunit of the Golgi-associated retrograde protein (GARP) complex that is involved in retrograde membrane trafficking to the Golgi.
Transport according to GARP: receiving retrograde cargo at the trans-Golgi network.
Review
Hierro et al., Bethesda, United States. In Trends Cell Biol, 2011
X-ray crystallography of the Vps53 and Vps54 subunits of GARP has revealed that this complex is structurally related to other tethering factors such as the exocyst, the conserved oligomeric Golgi (COG) and Dsl1 (dependence on SLY1-20) complexes, indicating that they all might work by a similar mechanism.
Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.
Bonifacino et al., Bethesda, United States. In Mol Biol Cell, 2010
In the yeast Saccharomyces cerevisiae, GARP comprises four subunits named Vps51p, Vps52p, Vps53p, and Vps54p.
Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes.
GeneRIF
Reinisch et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2010
the structure of a C-terminal fragment of the Vps53 subunit, important for binding endosome-derived vesicles, at a resolution of 2.9 A; structure of the Vps53 C terminus suggests that GARP belongs to this family of complexes.
Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.
GeneRIF
Bonifacino et al., Bethesda, United States. In Mol Cell Biol, 2009
Golgi-associated retrograde protein orchestrates retrograde transport from endosomes to the trans-Golgi network by promoting vesicle tethering and assembly of SNARE complexes in consecutive, independent steps.[Golgi associated retrograde protein]
Remote homology between Munc13 MUN domain and vesicle tethering complexes.
Grishin et al., Dallas, United States. In J Mol Biol, 2009
We found weak yet significant sequence similarities between the MUN domain and a set of protein subunits from several related vesicle tethering complexes, such as Sec6 from the exocyst complex and Vps53 from the Golgi-associated retrograde protein complex.
Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.
GeneRIF
Bonifacino et al., Bethesda, United States. In Mol Biol Cell, 2008
Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.
Identification of host proteins required for HIV infection through a functional genomic screen.
Impact
Elledge et al., Boston, United States. In Science, 2008
Further analysis revealed previously unknown roles for retrograde Golgi transport proteins (Rab6 and Vps53) in viral entry, a karyopherin (TNPO3) in viral integration, and the Mediator complex (Med28) in viral transcription.
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis.
GeneRIF
Ma et al., United States. In J Cell Sci, 2007
Amphipathic tail-anchoring peptide (ATAP) targets specifically to mitochondria, and induces caspase-dependent apoptosis that does not require Bax or Bak.
Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site.
GeneRIF
Yao et al., Shanghai, China. In Cell Res, 2006
Data show that transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site; observations provide insight into the mechanistic aspects of HCCS1 transcription regulation
Mutation in a homolog of yeast Vps53p accounts for the heat and osmotic hypersensitive phenotypes in Arabidopsis hit1-1 mutant.
GeneRIF
Wu et al., Taiwan. In Planta, 2006
The growth of yeast vps53Delta null mutant also shows reduced thermotolerance, and expression of HIT1 in this mutant can partially complement the defect, supporting the possibility of a conserved biological function for Vps53p and HIT1.
The putative Arabidopsis homolog of yeast vps52p is required for pollen tube elongation, localizes to Golgi, and might be involved in vesicle trafficking.
Bonhomme et al., Saint-Pierre-des-Corps, France. In Plant Physiol, 2004
The putative POK homolog in yeast (Saccharomyces cerevisiae), referred to as Vps52p/SAC2, has been shown to be located at the late Golgi and to function in a complex with other proteins, Vps53p, Vps54p, and Vps51p.
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