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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 May 2015.

VPS35 Vps35p

VPS35, Vps35p
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Vps29, Vps26, CAN, LRRK2, V1a
Papers using VPS35 antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 goat antibody (Santa Cruz Biotechnology).
Papers on VPS35
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
New
Hattori et al., Tokyo, Japan. In Febs Lett, 30 May 2015
VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26 via distinct domains.
Genetic variability of the retromer cargo recognition complex in parkinsonism.
New
Farrer et al., Vancouver, Canada. In Mov Disord, 30 Apr 2015
BACKGROUND: A pathogenic mutation (VPS35 p.D620N) within the retromer complex has been shown to segregate with late-onset Parkinson's disease (PD).
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.
New
Farrer et al., Vancouver, Canada. In Hum Mol Genet, 15 Apr 2015
Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to endosomal protein sorting and intracellular trafficking.
The endosomal pathway in Parkinson's disease.
Review
New
Tofaris et al., Oxford, United Kingdom. In Mol Cell Neurosci, Mar 2015
In this review, we summarized the evidence that a number of Parkinson's associated genetic mutations or polymorphisms (LRRK2, VPS35, GBA, ATP13A2, ATP6AP2, DNAJC13/RME-8, RAB7L1, GAK) disrupt protein trafficking and degradation via the endosomal pathway and discussed how such defects could arise from or contribute to the accumulation and misfolding of α-synuclein in Lewy bodies.
Retromer vesicles interact with RNA granules in haploid male germ cells.
New
Kotaja et al., Turku, Finland. In Mol Cell Endocrinol, Mar 2015
We identified a novel interaction between VPS26A/VPS35-containing retromer vesicles and the chromatoid body (CB), which is a large ribonucleoprotein (RNP) granule unique to haploid male germ cells.
Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.
Review
New
Schwamborn et al., Esch-sur-Alzette, Luxembourg. In Cell Mol Life Sci, Feb 2015
Indeed, animal models deficient in Nurr1, Pitx3, SNCA and PINK1 display deregulated embryonic neurogenesis and LRRK2 and VPS35 have been implicated in neuronal development-related processes such as Wnt/β-catenin signaling and neurite outgrowth.
Retromer contributes to immunity-associated cell death in Arabidopsis.
New
Hofius et al., Copenhagen, Denmark. In Plant Cell, Feb 2015
We report here that laz4 is mutated in one of three VACUOLAR PROTEIN SORTING35 (VPS35) genes.
Linking the VPS35 and EIF4G1 pathways in Parkinson's disease.
New
Petrucelli et al., Jacksonville, United States. In Neuron, Feb 2015
(2015) utilize a yeast model to establish a link between VPS35 and EIF4G1 in α-synuclein-related neurodegeneration.
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
New
Gitler et al., Stanford, United States. In Neuron, Feb 2015
Here we report an unexpected genetic interaction between two PD genes, VPS35 and EIF4G1.
Myrosin cell development is regulated by endocytosis machinery and PIN1 polarity in leaf primordia of Arabidopsis thaliana.
New
Hara-Nishimura et al., Kyoto, Japan. In Plant Cell, Nov 2014
By contrast, myrosin cell development was not affected by deficiencies of vacuolar trafficking factors, including the vacuolar sorting receptor VSR1 and the retromer components VPS29 and VPS35, suggesting that endocytic pathway rather than vacuolar trafficking pathway is important for myrosin cell development.
VPS35 Parkinson's disease phenotype resembles the sporadic disease.
Review
New
Austrian VPS-35 Investigators Team et al., Linz, Austria. In J Neural Transm, Jul 2014
Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered.
Genetics of Parkinson's disease: the yield.
Review
Wider et al., Lausanne, Switzerland. In Parkinsonism Relat Disord, 2014
Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations.
Update on novel familial forms of Parkinson's disease and multiple system atrophy.
Review
Wszolek et al., Jacksonville, United States. In Parkinsonism Relat Disord, 2014
Next-generation sequencing approaches in familial PD have identified mutations in the VPS35 gene.
Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population.
GeneRIF
Theuns et al., Antwerp, Belgium. In Neurobiol Aging, 2012
Hence, our data do not support a major role for VPS35 variations in the genetic etiology of Lewy body disorders in the Flanders-Belgian population.
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
GeneRIF
Chen et al., Shanghai, China. In Parkinsonism Relat Disord, 2012
This study suggested that VPS35 Asp620Asn may be not associated with PD in Chinese population.
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
GeneRIF
Rosen et al., Dallas, United States. In Mol Biol Cell, 2012
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35.
Identification of VPS35 mutations replicated in French families with Parkinson disease.
GeneRIF
French Parkinson's Disease Genetics Study Group et al., Toulouse, France. In Neurology, 2012
We have extended the number of autosomal dominant PD families with VPS35 mutations to 13 families, worldwide; D620N is the most frequent.
The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease.
GeneRIF
Goldwurm et al., In Mov Disord, 2012
Failed to find any case of VPS35 pAsp620Asn mutation in a cohort of Italian patients with familial Parkinson disease.
Functional architecture of the retromer cargo-recognition complex.
Impact
GeneRIF
Hurley et al., Bethesda, United States. In Nature, 2007
crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Impact
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2004
The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity.
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