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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

VPS35 Vps35p

VPS35, Vps35p
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Vps29, Vps26, CAN, LRRK2, V1a
Papers using VPS35 antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 goat antibody (Santa Cruz Biotechnology).
Papers on VPS35
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.
New
Aoki et al., Sendai, Japan. In Neurobiol Dis, 30 Nov 2014
Mutations in vacuolar protein sorting 35 (VPS35) have been linked to familial Parkinson's disease (PD).
Disease Penetrance of Late-Onset Parkinsonism: A Meta-analysis.
New
Farrer et al., Vancouver, Canada. In Jama Neurol, 20 Nov 2014
Importance: Mutations in SNCA, LRRK2, VPS35, EIF4G1, and DNAJC13 have been implicated in late-onset familial parkinsonism.
A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.
New
Craig et al., Vancouver, Canada. In J Biol Chem, 17 Nov 2014
Based on the presence of multiple components involved in trafficking and endocytosis, we showed that NL2 undergoes dynamin-dependent endocytosis in response to soluble ligand and colocalizes with VPS35 retromer in endosomes.
In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.
New
Tan et al., In Mol Brain, 08 Nov 2014
UNLABELLED: Mutations of VPS35, a component of the retromer complex have been associated with late onset familial Parkinson¿s disease.
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma membrane recycling.
New
Cullen et al., In J Cell Sci, 02 Nov 2014
Here, we have employed quantitative proteomics to define the interactome of human VPS35, the core retromer component.
Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.
Review
New
Roth, Buffalo, United States. In Neurotoxicology, 19 Sep 2014
These include the genes α-synuclein, parkin, PINK1, DJ-1, ATP13A2, and SLC30A10 which are associated with early-onset of Parkinson's as well as those genes linked with late onset of the disorder which include, LRRK2 and VPS35.
VPS35 and DNAJC13 disease-causing variants in essential tremor.
New
Vilariño-Güell et al., Saskatoon, Canada. In Eur J Hum Genet, 13 Sep 2014
UNLABELLED: Exome-sequencing analyses have identified vacuolar protein sorting 35 homolog (VPS35) and DnaJ (Hsp40) homolog, subfamily C, member 13 (DNAJC13) harboring disease-causing variants for Parkinson disease (PD).
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
New
Cullen et al., Dallas, United States. In Curr Biol, Aug 2014
Recently, a specific mutation in the retromer component VPS35, VPS35(D620N), has linked retromer dysfunction to familial autosomal dominant and sporadic Parkinson disease [2, 3].
Genetics of Parkinson's disease: the yield.
Review
New
Wider et al., Lausanne, Switzerland. In Parkinsonism Relat Disord, Jan 2014
Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations.
Update on novel familial forms of Parkinson's disease and multiple system atrophy.
Review
New
Wszolek et al., Jacksonville, United States. In Parkinsonism Relat Disord, Jan 2014
Next-generation sequencing approaches in familial PD have identified mutations in the VPS35 gene.
Genetics of Parkinson's disease--state of the art, 2013.
Review
New
Bonifati, Rotterdam, Netherlands. In Parkinsonism Relat Disord, Jan 2014
Highly-penetrant mutations in different genes (SNCA, LRRK2, VPS35, Parkin, PINK1, and DJ-1) are known to cause rare monogenic forms of the disease.
Analysis of the Retromer complex-WASH complex interaction illuminates new avenues to explore in Parkinson disease.
New
Freeman et al., Cambridge, United Kingdom. In Commun Integr Biol, Dec 2013
The WASH complex is recruited to endosomes by binding to the VPS35 subunit of retromer and facilitates cargo protein sorting by promoting formation of endosomally-localized F-actin.
The VPS35 gene and Parkinson's disease.
Review
New
Jankovic et al., Changsha, China. In Mov Disord, May 2013
Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD.
Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population.
GeneRIF
Theuns et al., Antwerp, Belgium. In Neurobiol Aging, 2012
Hence, our data do not support a major role for VPS35 variations in the genetic etiology of Lewy body disorders in the Flanders-Belgian population.
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
GeneRIF
Chen et al., Shanghai, China. In Parkinsonism Relat Disord, 2012
This study suggested that VPS35 Asp620Asn may be not associated with PD in Chinese population.
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
GeneRIF
Rosen et al., Dallas, United States. In Mol Biol Cell, 2012
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35.
Identification of VPS35 mutations replicated in French families with Parkinson disease.
GeneRIF
French Parkinson's Disease Genetics Study Group et al., Toulouse, France. In Neurology, 2012
We have extended the number of autosomal dominant PD families with VPS35 mutations to 13 families, worldwide; D620N is the most frequent.
The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease.
GeneRIF
Goldwurm et al., In Mov Disord, 2012
Failed to find any case of VPS35 pAsp620Asn mutation in a cohort of Italian patients with familial Parkinson disease.
Functional architecture of the retromer cargo-recognition complex.
Impact
GeneRIF
Hurley et al., Bethesda, United States. In Nature, 2007
crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Impact
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2004
The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity.
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