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VPS35 Vps35p

VPS35, Vps35p
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Vps29, Vps26, CAN, LRRK2, V1a
Papers using VPS35 antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 goat antibody (Santa Cruz Biotechnology).
Papers on VPS35
An assessment of the frequency of mutations in the GBA and VPS35 genes in Hungarian patients with sporadic Parkinson's disease.
New
Klivényi et al., Szeged, Hungary. In Neurosci Lett, 01 Feb 2016
Particular attention has recently been paid to genes of the glucocerebrosidase (GBA) and the vacuolar protein sorting-associated protein 35 (VPS35).
Analysis of the genetic variability in Parkinson's disease from Southern Spain.
New
Pittman et al., Granada, Spain. In Neurobiol Aging, 31 Jan 2016
Genetic analysis was performed through a next-generation sequencing panel to screen 8 PD-related genes (LRRK2, SNCA, PARKIN, PINK1, DJ-1, VPS35, GBA, and GCH1) in EOPD and FPD groups and direct Sanger sequencing of GBA exons 8-11 and LRRK2 exons 31 and 41 in the LOPD group.
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.
New
Impact
Zhu et al., Cleveland, United States. In Nat Med, 31 Jan 2016
The VPS35 gene, which encodes a key component of the membrane protein-recycling retromer complex, is the third autosomal-dominant gene associated with PD.
Phosphatidylinositol 3,5-bisphosphate-rich membrane domains in endosomes and lysosomes.
New
Fujimoto et al., Nagoya, Japan. In Traffic, 13 Dec 2015
This biased distribution of PtdIns(3,5)P2 was also observed using fluorescence microscopy, which further showed enrichment of a retromer component, VPS35, in the tubular domain.
VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.
New
Whitworth et al., Sheffield, United Kingdom. In Hum Mol Genet, Dec 2015
Mutations in VPS35 (PARK17) cause autosomal dominant, late onset Parkinson's disease (PD).
D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population.
New
Fidani et al., Thessaloníki, Greece. In Neurosci Lett, Nov 2015
Recently, vacuolar protein sorting 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) have been identified as new causal Parkinson's disease (PD) genes, with the VPS35 D620N and EIF4G1 R1205H mutations being identified in both autosomal dominant late-onset familial and sporadic PD patients.
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.
New
Xiong et al., Augusta, United States. In Cell Rep, Oct 2015
Vacuolar protein sorting-35 (VPS35) is a retromer component for endosomal trafficking.
De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease.
New
CNR-MAJ collaborators et al., Rouen, France. In Mol Psychiatry, Sep 2015
The two de novo CNVs (an amyloid precursor protein (APP) duplication and a BACE2 intronic deletion) and 3/12 non-synonymous DNVs (in PSEN1, VPS35 and MARK4) targeted genes from a biological network centered on the Amyloid beta (Aβ) peptide.
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease.
New
Xiong et al., Chongqing, China. In J Neurosci, Aug 2015
Vacuolar protein sorting-35 (VPS35) is essential for endosome-to-Golgi retrieval of membrane proteins.
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
New
Hattori et al., Tokyo, Japan. In Febs Lett, Jul 2015
VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26 via distinct domains.
The endosomal pathway in Parkinson's disease.
New
Tofaris et al., Oxford, United Kingdom. In Mol Cell Neurosci, May 2015
In this review, we summarized the evidence that a number of Parkinson's associated genetic mutations or polymorphisms (LRRK2, VPS35, GBA, ATP13A2, ATP6AP2, DNAJC13/RME-8, RAB7L1, GAK) disrupt protein trafficking and degradation via the endosomal pathway and discussed how such defects could arise from or contribute to the accumulation and misfolding of α-synuclein in Lewy bodies.
VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.
Xiong et al., Anyang, China. In Mol Brain, 2014
BACKGROUND: Vacuolar protein sorting 35 (VPS35), a key component of retromer, plays an important role in endosome-to-Golgi retrieval of membrane proteins.
Genetic Evidence for the Role of the Vacuole in Supplying Secretory Organelles with Ca2+ in Hansenula polymorpha.
Agaphonov et al., Moscow, Russia. In Plos One, 2014
Here we observed that in the yeast Hansenula polymorpha Ca2+ deficiency in the secretory pathway caused by Pmr1 inactivation is exacerbated by (i) the ret1-27 mutation affecting COPI-mediated vesicular transport, (ii) inactivation of the vacuolar Ca2+ ATPase Pmc1 and (iii) inactivation of Vps35, which is a component of the retromer complex responsible for protein transport between the vacuole and secretory organelles.
Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population.
GeneRIF
Theuns et al., Antwerp, Belgium. In Neurobiol Aging, 2012
Hence, our data do not support a major role for VPS35 variations in the genetic etiology of Lewy body disorders in the Flanders-Belgian population.
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
GeneRIF
Chen et al., Shanghai, China. In Parkinsonism Relat Disord, 2012
This study suggested that VPS35 Asp620Asn may be not associated with PD in Chinese population.
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
GeneRIF
Rosen et al., Dallas, United States. In Mol Biol Cell, 2012
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35.
Identification of VPS35 mutations replicated in French families with Parkinson disease.
GeneRIF
French Parkinson's Disease Genetics Study Group et al., Toulouse, France. In Neurology, 2012
We have extended the number of autosomal dominant PD families with VPS35 mutations to 13 families, worldwide; D620N is the most frequent.
The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease.
GeneRIF
Goldwurm et al., In Mov Disord, 2012
Failed to find any case of VPS35 pAsp620Asn mutation in a cohort of Italian patients with familial Parkinson disease.
Functional architecture of the retromer cargo-recognition complex.
Impact
GeneRIF
Hurley et al., Bethesda, United States. In Nature, 2007
crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Impact
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2004
The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity.
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