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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 20 Mar 2014.

VPS35 Vps35p

VPS35, Vps35p
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Vps29, Vps26, CAN, LRRK2, carboxypeptidase
Papers using VPS35 antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 goat antibody (Santa Cruz Biotechnology).
Papers on VPS35
RME-8 coordinates the WASH complex with the retromer SNX-BAR dimer to control endosomal tubulation.
New
Seaman et al., In J Cell Sci, 18 Apr 2014
Cargo selection is mediated by the VPS35-VPS29-VPS26 trimer, which additionally recruits the WASH complex via VPS35 binding to the WASH complex subunit FAM21.
VPS35 Parkinson's disease phenotype resembles the sporadic disease.
New
The Austrian VPS-35 Investigators Team et al., Linz, Austria. In J Neural Transm, 21 Mar 2014
UNLABELLED: Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered.
Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis.
New
Xiong et al., In Mol Brain, 11 Mar 2014
UNLABELLED: VPS35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins.
Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.
New
Small et al., New York City, United States. In Neurobiol Dis, 14 Feb 2014
Retromer-dependent trafficking is implicated in the pathogenesis of AD, and two key retromer proteins, VPS35 and VPS26, are deficient in the hippocampal formation of AD patients.
A mechanism for retromer endosomal coat complex assembly with cargo.
New
Burd et al., New Haven, United States. In Proc Natl Acad Sci U S A, 07 Feb 2014
Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29, and VPS35 proteins that selects and packages cargo proteins into transport carriers that export cargo from the endosome.
Genetics of Parkinson's disease: the yield.
New
Wider et al., Lausanne, Switzerland. In Parkinsonism Relat Disord, Jan 2014
Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations.
Update on novel familial forms of Parkinson's disease and multiple system atrophy.
New
Wszolek et al., Jacksonville, United States. In Parkinsonism Relat Disord, Jan 2014
Next-generation sequencing approaches in familial PD have identified mutations in the VPS35 gene.
Mutations in VPS26A are not a frequent cause of Parkinson's disease.
New
Lohmann et al., Lübeck, Germany. In Neurobiol Aging, Jan 2014
UNLABELLED: VPS35 mutations have been identified as a cause of autosomal dominantly inherited Parkinson's disease (PD).
The VPS35 gene and Parkinson's disease.
Review
New
Jankovic et al., Changsha, China. In Mov Disord, May 2013
Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD.
Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations.
Review
New
Puschmann, Lund, Sweden. In Parkinsonism Relat Disord, Apr 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
Review
Tofaris, Oxford, United Kingdom. In Mov Disord, 2012
VPS35 and LRRK2 may regulate trafficking within lysosome-dependent pathways, such as autophagy and endosomal vesicle recycling.
The genetics and neuropathology of Parkinson's disease.
Review
Singleton et al., London, United Kingdom. In Acta Neuropathol, 2012
We summarize the genetic, clinical and pathological findings of autosomal dominant disease linked to mutations in SNCA, LRRK2, ATXN2, ATXN3, MAPT, GCH1, DCTN1 and VPS35.
Contribution of VPS35 genetic variability to LBD in the Flanders-Belgian population.
GeneRIF
Theuns et al., Antwerp, Belgium. In Neurobiol Aging, 2012
Hence, our data do not support a major role for VPS35 variations in the genetic etiology of Lewy body disorders in the Flanders-Belgian population.
Genetics of Parkinson disease and other movement disorders.
Review
Klein et al., Lübeck, Germany. In Curr Opin Neurol, 2012
RECENT FINDINGS: Mutations in VPS35 were identified as a novel cause of autosomal dominant Parkinson disease using exome sequencing.
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
GeneRIF
Chen et al., Shanghai, China. In Parkinsonism Relat Disord, 2012
This study suggested that VPS35 Asp620Asn may be not associated with PD in Chinese population.
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
GeneRIF
Rosen et al., Dallas, United States. In Mol Biol Cell, 2012
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35.
Identification of VPS35 mutations replicated in French families with Parkinson disease.
GeneRIF
French Parkinson's Disease Genetics Study Group et al., Toulouse, France. In Neurology, 2012
We have extended the number of autosomal dominant PD families with VPS35 mutations to 13 families, worldwide; D620N is the most frequent.
The Asp620asn mutation in VPS35 is not a common cause of familial Parkinson's disease.
GeneRIF
Goldwurm et al., In Mov Disord, 2012
Failed to find any case of VPS35 pAsp620Asn mutation in a cohort of Italian patients with familial Parkinson disease.
Functional architecture of the retromer cargo-recognition complex.
Impact
GeneRIF
Hurley et al., Bethesda, United States. In Nature, 2007
crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Impact
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2004
The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity.
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