The genetics and neuropathology of Parkinson's disease.
London, United Kingdom. In Acta Neuropathol, Sep 2012
We summarize the genetic, clinical and pathological findings of autosomal dominant disease linked to mutations in SNCA, LRRK2, ATXN2, ATXN3, MAPT, GCH1, DCTN1 and VPS35.
Autosomal dominant Parkinson's disease.
Jacksonville, United States. In Parkinsonism Relat Disord, 2012
Recently two new autosomal dominant PD genes have been discovered, eukaryotic translation initiation factor 4-gamma (EIF4G1) and vacuolar protein sorting 35 (VPS35).
Update on genetics of parkinsonism.
Jacksonville, United States. In Neurodegener Dis, 2011
OBJECTIVE: We provide a brief review of the current status of PARK and non-PARK loci/genes, and discuss two new genes: eIF4G1 and VPS35.
VPS35 mutations in Parkinson disease.
Vancouver, Canada. In Am J Hum Genet, 2011
Disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process led to Parkinson disease.