The endosomal pathway in Parkinson's disease.
Oxford, United Kingdom. In Mol Cell Neurosci, 19 Mar 2015
In this review, we summarized the evidence that a number of Parkinson's associated genetic mutations or polymorphisms (LRRK2, VPS35, GBA, ATP13A2, ATP6AP2, DNAJC13/RME-8, RAB7L1, GAK) disrupt protein trafficking and degradation via the endosomal pathway and discussed how such defects could arise from or contribute to the accumulation and misfolding of α-synuclein in Lewy bodies.
Genetics of Parkinson's disease: the yield.
Lausanne, Switzerland. In Parkinsonism Relat Disord, 2014
Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations.
The VPS35 gene and Parkinson's disease.
Changsha, China. In Mov Disord, 2013
Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD.