A mechanism for retromer endosomal coat complex assembly with cargo.
New Haven, United States. In Proc Natl Acad Sci U S A, 07 Feb 2014
Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29, and VPS35 proteins that selects and packages cargo proteins into transport carriers that export cargo from the endosome.
Genetics of Parkinson's disease: the yield.
Lausanne, Switzerland. In Parkinsonism Relat Disord, 31 Jan 2014
Monogenic causes include autosomal dominantly (SNCA, LRRK2, VPS35, EIF4G1) as well as recessively (PARK2, PINK1, DJ-1) inherited mutations.
The VPS35 gene and Parkinson's disease.
Changsha, China. In Mov Disord, May 2013
Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late-onset PD, has provided new clues to the pathogenesis of PD.
VPS35 mutations in Parkinson disease.
Vancouver, Canada. In Am J Hum Genet, 2011
Disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process led to Parkinson disease.