GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
VPS35 Vps35p
VPS35, Vps35p
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
VPS35
antibodies
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
Supplier
In Molecular Neurodegeneration, 2007
... polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 goat antibody (Santa Cruz Biotechnology).
Papers on
VPS35
Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.
New
Miami, United States. In Neurology, 12 Apr 2013
OBJECTIVE: Recently, vacuolar protein sorting 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) have been identified as 2 causal Parkinson disease (PD) genes.
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
New
Lund, Sweden. In Parkinsonism Relat Disord, 22 Mar 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk.
New
New York City, United States. In Neuron, 06 Mar 2013
PD-associated defects in RAB7L1 or LRRK2 led to endolysosomal and Golgi apparatus sorting defects and deficiency of the VPS35 component of the retromer complex.
Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis.
New
Lyon, France. In J Biol Chem, 01 Mar 2013
In mammals, it is composed of a dimer of Sorting Nexins (SNXs) and of the core retromer consisting of Vacuolar Protein Sorting (VPS)26, VPS29 and VPS35.
Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
New
Gif-sur-Yvette, France. In Biol Cell, 18 Feb 2013
The CSC is composed of three subunits, VPS35, VPS29 and VPS26.
Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.
New
New Haven, United States. In Mbio, Dec 2012
Reducing the levels of the retromer cargo-adapter VPS26-VPS29-VPS35 complex or retromer-associated sorting nexins abrogated C. burnetii replication.
Pathogenic Mutation in VPS35 Impairs Its Protection against MPP(+) Cytotoxicity.
New
Philadelphia, United States. In Int J Biol Sci, Dec 2012
Recent studies indicate that mutation in the vacuolar protein sorting 35 (vps35) gene segregates with Parkinson's disease in some families, but how mutation in the vps35 gene causes dopaminergic cell death is not known.
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
Review
New
Oxford, United Kingdom. In Mov Disord, Oct 2012
VPS35 and LRRK2 may regulate trafficking within lysosome-dependent pathways, such as autophagy and endosomal vesicle recycling.
The genetics and neuropathology of Parkinson's disease.
Review
New
London, United Kingdom. In Acta Neuropathol, Sep 2012
We summarize the genetic, clinical and pathological findings of autosomal dominant disease linked to mutations in SNCA, LRRK2, ATXN2, ATXN3, MAPT, GCH1, DCTN1 and VPS35.
Genetics of Parkinson disease and other movement disorders.
Review
New
Lübeck, Germany. In Curr Opin Neurol, Aug 2012
RESULTS: Mutations in VPS35 were identified as a novel cause of autosomal dominant Parkinson disease using exome sequencing.
The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.
New
New York City, United States. In Future Neurol, Aug 2012
The retromer contains two subprotein complexes: the cargo-selective subcomplex consisting of VPS35, VPS29 and VPS26 and the membrane deformation subcomplex consisting of Vps5p, Vps17p, SNX 1/2 and possibly SNX 5/6 or SNX 32 in mammals.
Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability.
GeneRIF
Seoul, South Korea. In Hum Pathol, 2012
Frameshift mutations of VPS genes and losses of expression of Vps13A and Vps35 proteins are common in gastric cancers and colorectal cancers with high microsatellite instability.
Autosomal dominant Parkinson's disease.
Review
Jacksonville, United States. In Parkinsonism Relat Disord, 2012
Recently two new autosomal dominant PD genes have been discovered, eukaryotic translation initiation factor 4-gamma (EIF4G1) and vacuolar protein sorting 35 (VPS35).
Update on genetics of parkinsonism.
Review
Jacksonville, United States. In Neurodegener Dis, 2011
OBJECTIVE: We provide a brief review of the current status of PARK and non-PARK loci/genes, and discuss two new genes: eIF4G1 and VPS35.
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.
GeneRIF
Augusta, United States. In J Cell Biol, 2011
VPS35 as an essential role in the suppression of AD neuropathology and in the inhibition of BACE1 activation and Abeta production by promoting BACE1 endosome-to-Golgi retrieval.
Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation.
GeneRIF
United States. In J Virol, 2011
The amino-terminal conserved, glutamate-rich sequence of herpesvirus saimiri Tip specifically interacts with the human retromer subunit Vps35 and inhibits retromer activity.
VPS35 mutations in Parkinson disease.
GeneRIF
Vancouver, Canada. In Am J Hum Genet, 2011
Disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process led to Parkinson disease.
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
GeneRIF
Vienna, Austria. In Am J Hum Genet, 2011
Only a single heterozygous variant in the VPS35 gene caused late-onset Parkinson disease in this family.
Functional architecture of the retromer cargo-recognition complex.
Impact
GeneRIF
Bethesda, United States. In Nature, 2007
crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Impact
San Francisco, United States. In Nat Cell Biol, 2004
The other is the Vps35p-Vps29p-Vps26p subcomplex, which provides cargo specificity.
