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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

VPS34 Vps34p

Vps34, Vps34p, PIK3C3
Encodes a phosphatidylinositol 3-kinase that is expressed in most plant tissues. Defects in VPS34 affect a number of cellular processes. Loss of function mutations are not transmitted through the male gametophyte due to defects in microgametogenesis therefore it is difficult to assess the effects of loss of VPS34 function in the whole plant. Involved in salt-stress responses. (from NCBI)
Top mentioned proteins: CAN, PI3K, V1a, ACID, LC3
Papers on Vps34
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.
New
Chen et al., Taipei, Taiwan. In Mol Cell, Feb 2016
Additionally, KLHL20 governs the degradation of ATG13, VPS34, Beclin-1, and ATG14 in prolonged starvation through a direct or indirect mechanism.
SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response.
New
Deaglio et al., In J Clin Invest, Feb 2016
Beclin1 dissociated from BCL2 in response to SLAMF1 ligation, resulting in formation of the autophagy macrocomplex, which contains SLAMF1, beclin1, and the enzyme VPS34.
FGF signalling regulates bone growth through autophagy.
New
Impact
Settembre et al., Pozzuoli, Italy. In Nature, Jan 2016
Surprisingly, post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1.
GADD45A inhibits autophagy by regulating the interaction between BECN1 and PIK3C3.
New
Zhan et al., Beijing, China. In Autophagy, Nov 2015
Likely, GADD45A inhibition of autophagy is through its influence on the interaction between BECN1 and PIK3C3.
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
New
Impact
Williams et al., Brussels, Belgium. In Science, Nov 2015
Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis, and autophagy.
BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.
New
Wang et al., Lexington, United States. In Front Biol, Oct 2015
The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity.
WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome.
Review
New
Kohlbacher et al., Tübingen, Germany. In J Cell Sci, Feb 2015
Prerequisite and essential for autophagosome formation is the production of phosphatidylinositol 3-phosphate (PtdIns3P) by phosphatidylinositol 3-kinase class III (PI3KC3, also known as PIK3C3) in complex with beclin 1, p150 (also known as PIK3R4; Vps15 in yeast) and ATG14L.
Ironing out VPS34 inhibition.
Impact
Debnath et al., In Nat Cell Biol, 2015
The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation.
Beclin 1 biology and its role in heart disease.
Review
He et al., Shanghai, China. In Curr Cardiol Rev, 2014
Beclin 1 primarily functions as a scaffolding protein assembling Beclin 1 interactome to regulate Class III PI3K/VPS34 activity, which in turn, tightly controls autophagy at multiple stages.
The role of STAT3 in autophagy.
Review
Han et al., Hangzhou, China. In Autophagy, 2014
For example, nuclear STAT3 fine-tunes autophagy via the transcriptional regulation of several autophagy-related genes such as BCL2 family members, BECN1, PIK3C3, CTSB, CTSL, PIK3R1, HIF1A, BNIP3, and microRNAs with targets of autophagy modulators.
Beclin 1 regulates neuronal transforming growth factor-β signaling by mediating recycling of the type I receptor ALK5.
Wyss-Coray et al., Stanford, United States. In Mol Neurodegener, 2014
Decreased levels of beclin 1, or its binding partners VPS34 and UVRAG, impair TGF-β signaling.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Impact
Murphy et al., Cambridge, United States. In Nat Cell Biol, 2014
PIK-III is a selective inhibitor of VPS34 that binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα.
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.
Review
Platta et al., Bochum, Germany. In Cancers (basel), 2013
Interestingly, all three pathways are controlled by the same central signaling module: the class III phosphatidylinositol 3-kinase (PI3K-III) complex and its catalytic product, the phosphorylated lipid phosphatidylinositol 3-phosphate (PtdIns3P).
Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.
Review
Chiang et al., State College, United States. In Membranes (basel), 2013
FBPase internalization also requires the VPS34 gene encoding PI3K.
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance.
Impact
Levine et al., Dallas, United States. In Cell, 2013
Active EGFR binds the autophagy protein Beclin 1, leading to its multisite tyrosine phosphorylation, enhanced binding to inhibitors, and decreased Beclin 1-associated VPS34 kinase activity.
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer.
GeneRIF
Hu et al., Beijing, China. In Cancer Res, 2012
Via direct interaction with the class III PI-3-kinase (PI3KC3)/Beclin1, DEDD activated autophagy and induced the degradation of Snail and Twist, two master regulators of EMT
Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.
GeneRIF
Flavell et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
Data show that Vps34 was dispensable for T-cell development but important for the survival of naive T cells.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
GeneRIF
Terhorst et al., Boston, United States. In J Biol Chem, 2012
conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.
GeneRIF
Zong et al., Stony Brook, United States. In Proc Natl Acad Sci U S A, 2012
Vps34 plays an essential role in regulating functional autophagy and is indispensable for normal liver and heart function.
Arabidopsis AtVPS15 plays essential roles in pollen germination possibly by interacting with AtVPS34.
GeneRIF
Qu et al., Beijing, China. In J Genet Genomics, 2012
Data demonstrated that AtVPS15 might interact directly with AtVPS34 and suggested that AtVPS15 is very important for pollen germination, possibly through modulation of the activity of PI3-kinase.
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