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Vacuolar protein sorting 25 homolog

Vps25, EAP20
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Vps22, CAN, V1a, ACID, TSG101
Papers on Vps25
Involvement of ESCRT-II in hepatitis B virus morphogenesis.
Prange et al., Mainz, Germany. In Plos One, 2013
Here, we have investigated the impact of the upstream-acting ESCRT-I and ESCRT-II complexes in HBV morphogenesis.
De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis.
Bergmann et al., Houston, United States. In Plos One, 2012
Multiple genes involved in endocytosis and endosomal protein trafficking in Drosophila have been shown to function as neoplastic tumor suppressor genes (nTSGs), including Endosomal Sorting Complex Required for Transport-II (ESCRT-II) components vacuolar protein sorting 22 (vps22), vps25, and vps36.
ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly.
Mouland et al., Montréal, Canada. In Biol Cell, 2012
This treatment disrupted ESCRT-II function and leads to the degradation of the two other ESCRT-II complex proteins, EAP45 and EAP20, as well as the associated Rab7-interacting lysosomal protein.
Notch signaling activates Yorkie non-cell autonomously in Drosophila.
Bergmann et al., Houston, United States. In Plos One, 2011
The non-cell autonomous induction of Yorkie is due to Notch signaling from vps25 mutant cells.
Vacuolar protein sorting genes regulate mat formation in Saccharomyces cerevisiae by Flo11p-dependent and -independent mechanisms.
Reynolds et al., Knoxville, United States. In Eukaryot Cell, 2011
In contrast, an overlapping subset of MVB mutants (represented by ESCRT [endosomal sorting complex required for transport] complex genes such as VPS25) interrupt the Rim101p signal transduction cascade, which is required for FLO11 expression, and thus block both invasive growth and mat formation.
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Emr et al., Innsbruck, Austria. In Embo J, 2010
ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.
Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans.
Madhani et al., San Francisco, United States. In Plos One, 2009
Several melanization-defective mutants identified previously, those in the RIM20, RIM101, and VPS25 genes, also display sensitivity to copper starvation, reduced capsule production and increased phagocytosis.
Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.
Hurley et al., Bethesda, United States. In Dev Cell, 2009
Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20.
Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors.
Moberg et al., Atlanta, United States. In Plos One, 2008
synatxin7/avalanche, rab5, and vps25) produces disorganized overgrowth of imaginal disc tissue.
Common and distinct genetic properties of ESCRT-II components in Drosophila.
Bergmann et al., Houston, United States. In Plos One, 2008
In Drosophila, mutations of the ESCRT-II component vps25 cause endosomal defects leading to accumulation of Notch protein and increased Notch pathway activity.
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.
Hurley et al., Bethesda, United States. In Dev Cell, 2008
ESCRT-II binds to the ESCRT-I VPS28 C-terminal domain subunit through a helix immediately C-terminal to the VPS36-GLUE domain.
bicoid RNA localization requires specific binding of an endosomal sorting complex.
St Johnston et al., Cambridge, United Kingdom. In Nature, 2007
Here we show that mutants in all subunits of the ESCRT-II complex (VPS22, VPS25 and VPS36) abolish the final Staufen-dependent step in bicoid mRNA localization.
CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway.
Maki et al., Nagoya, Japan. In Biochem J, 2006
Among the ten CHMP proteins classified previously in six subfamilies (CHMP1-CHMP6), the C-terminal SNF7 domain of CHMP7 is most similar to the SNF7 domain of CHMP6, which associates with CHMP4 proteins and EAP20, a component of ESCRT-II.
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.
Sundquist et al., Salt Lake City, United States. In J Virol, 2006
Consistent with its expected role in MVB vesicle formation, (i) human ESCRT-II localized to endosomal membranes in a VPS4-dependent fashion and (ii) depletion of EAP20/ESCRT-II and CHMP6/ESCRT-III inhibited lysosomal targeting and downregulation of the epidermal growth factor receptor, albeit to a lesser extent than depletion of TSG101/ESCRT-I.
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors.
Stenmark et al., Oslo, Norway. In Mol Biol Cell, 2006
Clones of fab1 mutant cells accumulate Wingless and Notch, similarly to cells lacking Hrs, Vps25, and Tsg101, components of the endosomal sorting machinery for ubiquitinated membrane proteins.
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.
Luzio et al., Cambridge, United Kingdom. In J Biol Chem, 2006
mammalian ESCRTII is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body
Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component.
Bishop et al., Manchester, United Kingdom. In Bmc Evol Biol, 2005
BACKGROUND: Vps25p is the product of yeast gene VPS25 and is found in an endosomal sorting complex required for transport (ESCRT)-II, along with Vps22p and Vps36p.
Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila.
Cohen et al., Heidelberg, Germany. In Dev Cell, 2005
The vps25 protein encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome.
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