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VPS16 Vps16p

Vps16, Vps16p, vpt16
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: PEP3, Sox11, STEP, CAN, VPS33B
Papers on Vps16
Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.
New
Luzio et al., Cambridge, United Kingdom. In Traffic, Jul 2015
The mammalian homotypic fusion and vacuole protein sorting (HOPS) complex is comprised of six subunits: VPS11, VPS16, VPS18, VPS39, VPS41 and the Sec1/Munc18 (SM) family member VPS33A.
The vacuolar protein sorting genes in insects: A comparative genome view.
New
Blissard et al., China. In Insect Biochem Mol Biol, Jul 2015
However, in contrast to the VPS gene expansions observed in the human genome, only four VPS genes (VPS13, VPS16, VPS33, and VPS37) were expanded in the six insect Orders.
Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation.
Li et al., Beijing, China. In Autophagy, 2014
In addition, the VPS33A(D251E) mutation enhanced interactions with other HOPS subunits, namely VPS41, VPS39, VPS18, and VPS11, except for VPS16.
The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.
Mizushima et al., Tokyo, Japan. In Mol Biol Cell, 2014
Immunoprecipitation and mass spectrometry analysis identified vacuolar protein sorting 33A (VPS33A) and VPS16, which are components of the homotypic fusion and protein sorting (HOPS)-tethering complex.
Saccharomyces cerevisiae mutants affected in vacuole assembly or vacuolar H+-ATPase are hypersensitive to lead (Pb) toxicity.
Soares et al., Porto, Portugal. In Curr Microbiol, 2014
Cells disrupted in VPS16 gene, did not display a detectable vacuolar-like structure.
The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila.
Krämer et al., Dallas, United States. In J Cell Biol, 2011
Both encode homologues of the Vps33p and Vps16p subunits of the HOPS complex necessary for fusions of vacuoles in yeast.
Reduced expression of vps11 causes less pigmentation in medaka, Oryzias latipes.
Kanamori et al., Nagoya, Japan. In Pigment Cell Res, 2006
Vps 11 is one of the evolutionarily conserved class C vacuolar protein sorting genes (c-vps: vps11, vps16, vps18, and vps33), whose products physically associate to form the c-vps protein complex required for vesicle docking and fusion in the budding yeast.
Expression of the mammalian homologue of vacuolar protein sorting 16 (Vps16p) in the mouse and rat brain.
GeneRIF
Akazawa et al., Kodaira, Japan. In Neurosci Lett, 2004
Vps16p is highly expressed in neurons of various brain areas and developmental stages tested; it colocalizes with microtubule associated protein 2, but not glial fibrillary acidic protein.
Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.
GeneRIF
Akazawa et al., Kodaira, Japan. In Biochem Biophys Res Commun, 2003
mVps16p has potential roles in membrane trafficking
Mutations that affect vacuole biogenesis inhibit proliferation of the endoplasmic reticulum in Saccharomyces cerevisiae.
Wright et al., Seattle, United States. In Genetics, 2002
Two independently isolated, temperature-sensitive strains that were also defective for karmellae biogenesis carried mutations in VPS16, a gene involved in vacuolar protein sorting.
VACUOLELESS1 is an essential gene required for vacuole formation and morphogenesis in Arabidopsis.
Raikhel et al., East Lansing, United States. In Dev Cell, 2001
Consistent with a role in vacuole biogenesis, we show that VCL1 encodes the Arabidopsis ortholog of yeast Vps16p.
Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.
Krämer et al., Bethesda, United States. In Gene, 2001
In multicellular organisms, the delivery of proteins to lysosomes is essential.
Mutations in VPS16 and MRT1 stabilize mRNAs by activating an inhibitor of the decapping enzyme.
Peltz et al., United States. In Mol Cell Biol, 1999
Using an in vitro decapping assay, we have identified a factor, Vps16p, that regulates the activity of the yeast decapping enzyme, Dcp1p.
Nystatin effects on vacuolar function in Saccharomyces cerevisiae.
Takegawa et al., Japan. In Biosci Biotechnol Biochem, 1999
The nss1 mutant was demonstrated to have a mutational lesion in the known VPS16 gene, which is essential for vacuolar protein sorting in S. cerevisiae.
Isolation of yeast mutants defective for localization of vacuolar vital dyes.
Vida et al., Houston, United States. In Proc Natl Acad Sci U S A, 1998
Limited genetic overlap was observed with previously isolated mutants, namely svl2/vps41, svl6/vps16, and svl7/fab1.
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