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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

VPS15 Vps15p

Vps15, Vps15p
Top mentioned proteins: Vps34, carboxypeptidase, ACID, PI3K, V1a
Papers on Vps15
Co-occurence of filamentation defects and impaired biofilms in Candida albicans protein kinase mutants.
New
Morrissey et al., Cork, Ireland. In Fems Yeast Res, Dec 2015
Five genes, VPS15, IME2, PKH3, PGA43 and CEX1, encode proteins not previously reported to influence hyphal development or biofilm formation.
Autophagy regulation: RNF2 targets AMBRA1.
Codogno et al., Paris, France. In Cell Res, 2014
The phosphatidylinositol 3-kinase complex I (PI3K complex I) is a crucial regulator of autophagy, which contains Beclin 1 (or ATG6), ATG14L, VPS34 (or the class III phosphatidylinositol 3-kinase and its adaptor VPS15) and AMBRA1, and controls autophagosome formation.
Autophagy suppression by appendicitis and appendectomy protects against colitis.
Grimm et al., Sydney, Australia. In Inflamm Bowel Dis, 2014
RESULTS: Out of 28 key autophagy-related genes investigated (VPS15, VPS34, FIP200, ATG03, ATG04A, ATG04B, ATG05, ATG07, ATG10, ATG12, ATG13b, ATG14, ATG16L1, BECN1, GABARAPL1, IRGM1, IRGM2, LAMP2, LC3A, LC3B, RAB7A, UVRAG, NOD2, XBP1, LRRK2, ULK1, ULK2, PTPN2), 7 have genetic associations with inflammatory bowel diseases (ATG16L1, IRGM1, NOD2, XBP1, LRRK2, ULK1, PTPN2).
Autophagic kinases SmVPS34 and SmVPS15 are required for viability in the filamentous ascomycete Sordaria macrospora.
Pöggeler et al., Göttingen, Germany. In Microbiol Res, 2014
In yeast, the phosphatidylinositol 3-kinase vacuolar protein sorting 34 (Vps34) and its myristoylated membrane targeting unit, the protein kinase Vps15 have been shown to be important regulators of autophagy and vacuolar protein sorting.
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.
Hurley et al., Berkeley, United States. In Elife, 2013
The class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) that functions in early autophagy consists of the lipid kinase VPS34, the scaffolding protein VPS15, the tumor suppressor BECN1, and the autophagy-specific subunit ATG14.
Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.
Review
Platta et al., Bochum, Germany. In Cancers (basel), 2013
The activity of the catalytic subunit of the PI3K-III complex, the lipid-kinase VPS34, requires the presence of the membrane-targeting factor VPS15 as well as the adaptor protein Beclin 1. Furthermore, a growing list of regulatory proteins associates with VPS34 via Beclin 1.
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression.
Review
Platta et al., Oslo, Norway. In Febs Lett, 2012
The activity of the catalytic unit of PI3K-III complex, the Vacuolar sorting protein 34 (VPS34), depends on the membrane targeting unit Vacuolar sorting protein 15 (VPS15), and the tumor suppressor protein Beclin 1.
Arabidopsis AtVPS15 plays essential roles in pollen germination possibly by interacting with AtVPS34.
Qu et al., Beijing, China. In J Genet Genomics, 2012
VPS15 protein is a component of the phosphatidylinositol 3-kinase complex which plays a pivotal role in the development of yeast and mammalian cells.
Arabidopsis AtVPS15 is essential for pollen development and germination through modulating phosphatidylinositol 3-phosphate formation.
Zhang et al., China. In Plant Mol Biol, 2011
In yeast, Vps15p is required for the membrane targeting and activity of Vps34.
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
GeneRIF
Stenmark et al., Oslo, Norway. In Exp Cell Res, 2011
A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required.
Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.
Kuno et al., Kōbe, Japan. In Mol Genet Genomics, 2010
Furthermore, we isolated vps15 (+) gene, encoding a serine/threonine protein kinase, as a dosage-dependent suppressor of the temperature-sensitive phenotype of ric1-v3 mutant, but not that of Deltaric1 cells.
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells.
GeneRIF
Backer et al., United States. In Biochem J, 2009
hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.
Impact
GeneRIF
Dohlman et al., Chapel Hill, United States. In Cell, 2006
Gpa1 is present at endosomes, where it interacts directly with both Vps34 and Vps15 and stimulates increased production of phosphatidylinositol 3-phosphate.
Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome.
Impact
Moore et al., Cambridge, United States. In Nat Genet, 1996
Analysis of the CHS polypeptide demonstrates that its modular architecture is similar to the yeast vacuolar sorting protein, VPS15.
Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteins.
Review
Emr et al., San Diego, United States. In Annu Rev Cell Dev Biol, 1994
The VPS15 and VPS34 genes encode components of a novel signal transduction complex essential for the delivery of soluble vacuolar hydrolases.
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole.
Impact
Emr et al., Pasadena, United States. In Cell, 1991
The VPS15 gene encodes a novel protein kinase homolog that is essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
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