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Pre-B lymphocyte gene 3

VpreB3, 8HS-20
The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: VpreB, c-Myc, CD45, lambda5, HAD
Papers on VpreB3
Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.
Sasano et al., Sendai, Japan. In Endocr Pathol, May 2015
The pre-B lymphocyte protein 3 (VPREB3) is expressed during B cell differentiation and in subsets of mature B lymphocytes and is mainly found in bone marrow and lymphoid tissue germinative centers.
The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B-cell lymphomas.
Tinguely et al., Zürich, Switzerland. In Hematol Oncol, 2014
In particular, mutations in the transcription factors ID3 and TCF3, leading to overexpression of B-cell receptor components such as VPREB3, have been shown to be specific for Burkitt lymphoma (BL) and play an important tumourigenic role by mediating the activation of the pro-survival phosphatidylinositol-3-OH kinase pathway.
A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.
Miller et al., Albuquerque, United States. In Immunogenetics, 2012
Comparing the opossum VpreB to homologues from eutherian (placental mammals) and avian species supported the marsupial gene being VpreB3.
B lymphopoiesis is characterized by pre-B cell marker gene expression in fetal cattle and declines in adults.
Iivanainen et al., Helsinki, Finland. In Dev Comp Immunol, 2012
The marked differences in the expression profiles of VPREB2 and VPREB3 in comparison to those of VPREB1, IGLL1 and RAGs suggest that the biological roles of VPREB2 and VPREB3 are unrelated to the pre-B cells.
The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.
Marafioti et al., Boston, United States. In Haematologica, 2010
Recent profiling studies unexpectedly revealed abundant transcripts of one member of the VpreB family, VpreB3, in a subset of mature B cells and Burkitt lymphoma.
Clinical, immunophenotypic, and genetic characterization of small lymphocyte-like plasma cell myeloma: a potential mimic of mature B-cell lymphoma.
Shaughnessy et al., Little Rock, United States. In Am J Clin Pathol, 2010
Most cases share a common GEP signature dominated by hyperexpression of cyclin D1 or cyclin D3 genes, with increased expression of the B-cell genes CD20 and VPREB3.
Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor.
Jäck et al., Erlangen, Germany. In Mol Immunol, 2008
Pre-B cell receptor (BCR) signals establish the molecular network for BCR signaling even before the production of an IgL Chain and induce the expression of KLF2, a candidate for controlling clonal expansion and migration of functional pre-B cells.
Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.
Martinez-Valdez et al., Houston, United States. In J Biol Chem, 2005
the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation.
Pearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor.
Sigvardsson et al., Lund, Sweden. In J Biol Chem, 2004
Comparing the expression pattern of EBF to that of the other genes in the data set revealed that VpreB1, mb-1, and lambda5, all known target genes, presented high correlation values to EBF. High correlations were also seen for the VpreB3 and CD19 genes and biochemical as well as functional data supported that they are target genes for EBF even though the expression of CD19 was critically dependent of Pax-5.
Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.
Schiff et al., Marseille, France. In J Biol Chem, 2004
VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in B cells
Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
Kline et al., Basel, Switzerland. In J Immunol, 2002
Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse.
Schiff et al., Marseille, France. In Cytogenet Cell Genet, 1998
During the early phase of pre-BCR assembly in the mouse, the membrane Ig mu heavy chain transiently associates with the VPREB3 protein in the endoplasmic reticulum.
Expression of Vpre-B3 (8HS-20) molecules by alternative RNA processing.
Takemori et al., Tokyo, Japan. In Int Immunol, 1996
In addition to their association with lambda 5 and Vpre-B1, mu chains in pre-B cells are associated with the products of the Vpre-B3 gene (formerly designated 8HS-20), which display a distinct association with mu chains and biochemical properties in terms of mol.
Transgenic expression of VpreB-3 under the control of the immunoglobulin heavy chain enhancer and SV40 promoter.
Hagiwara, Kōbe, Japan. In Kobe J Med Sci, 1996
Recently we isolated a novel gene, VpreB-3 gene from the cDNA library of a pre-B cell clone.
Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines.
Takemori et al., Tokyo, Japan. In J Biol Chem, 1994
p18(8.6), and p14(7.0), in addition to lambda 5, VpreB1, VpreB3 (formerly named 8HS20), MB-1(Ig-alpha), and B29(Ig-beta).
A novel gene product associated with mu chains in immature B cells.
Takemori et al., Tokyo, Japan. In Embo J, 1993
A previously unreported B cell specific gene, which we have named 8HS-20, was isolated from the cDNA library of a pre-B cell clone by subtraction and differential hybridization.
Characterization of a new subgroup of human Ig V lambda cDNA clone and its expression.
Takemori et al., Tokyo, Japan. In Mol Immunol, 1992
From a human bone marrow cDNA library, we have cloned and sequenced a gene which cross-hybridized with murine pre-B cell-specific gene 8HS-20 cDNA under the low-stringent condition.
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