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Pre-B lymphocyte gene 3

VpreB3, 8HS-20
The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells. [provided by RefSeq, Sep 2008] (from NCBI)
Papers on VpreB3
Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor.
GeneRIF
J├Ąck et al., Erlangen, Germany. In Mol Immunol, 2008
Pre-B cell receptor (BCR) signals establish the molecular network for BCR signaling even before the production of an IgL Chain and induce the expression of KLF2, a candidate for controlling clonal expansion and migration of functional pre-B cells.
Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript.
GeneRIF
Martinez-Valdez et al., Houston, United States. In J Biol Chem, 2005
the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation.
Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells.
GeneRIF
Schiff et al., Marseille, France. In J Biol Chem, 2004
VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in B cells
Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
GeneRIF
Kline et al., Basel, Switzerland. In J Immunol, 2002
Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
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