LPS-Enhanced Glucose-Stimulated Insulin Secretion Is Normalized by Resveratrol.
Århus, Denmark. In Plos One, Dec 2015
LPS induced insulin resistance as the glucose-stimulated insulin secretion during an oral glucose tolerance test was increased despite similar plasma glucose level resulting in an increase in the insulinogenic index (IGI; delta0-15insulin / delta0-15glucose) from 13.73 to 22.40 pmol/mmol (P < 0.001).
Structural insight into pre-B cell receptor function.
Stanford, United States. In Science, 2007
In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire.
The kappa-like pre-B receptor: surplus biology or a missing link?
Houston, United States. In Semin Immunol, 2006
The present review discusses the concept of the alternative usage of kappa-like pre-B cell receptors and classical pre-B cell receptors utilizing the lambda-like surrogate light chain composed of lambda5 and VpreB.