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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Von Hippel-Lindau

von Hippel-Lindau, VHL, dVHL
Top mentioned proteins: VHL, CAN, HAD, XRCC1, vascular endothelial growth factor
Papers using von Hippel-Lindau antibodies
TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
Supplier
Hiraoka M et al., In British Journal of Cancer, 2007
... cell carcinoma cell lines (RCC4) stably transfected with pcDNA3 (an empty vector) and pcDNA3-VHL (a VHL-expressing vector), respectively, were purchased from DS Pharma Biomedical (Osaka, Japan) ...
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
Supplier
Gnarra James R. et al., In Oncogene, 2007
... Anti-VHL (Ig32) was purchased from BD Pharmingen, anti-HA (Y-11), anti-cyclin B1, anti-cdc27 and anti-VHL (FL-181) antibodies were purchased from Santa Cruz Biotechnology, and anti-myc (9E10) antibody ...
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
Supplier
Rozakis-Adcock M et al., In Oncogene, 2006
... (Santa Cruz, CA, USA); Phospho-Erk1/2 and Erk1/2 antibodies from Zymed Laboratories (San Francisco, CA, USA); VHL antibodies from BD Biosciences (San Jose, CA, USA) ...
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
Supplier
Jin Dong-Yan, In PLoS ONE, 2006
... The VHL antibodies were from Cell signaling technology Inc ...
TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor.
Supplier
Koritzinsky Marianne, In PLoS ONE, 2004
... pVHL antibody was from BD Biosciences (Bedford, MA) ...
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Papers on von Hippel-Lindau
Axitinib for the treatment of metastatic renal cell carcinoma.
New
Rini et al., Cleveland, United States. In Future Oncol, Feb 2016
UNASSIGNED: Renal cell carcinoma is a cancer that results from a genetic inactivation of the VHL tumor suppressor gene leading to an upregulation of VEGF.
An ID2-dependent mechanism for VHL inactivation in cancer.
New
Impact
Lasorella et al., New York City, United States. In Nature, Feb 2016
ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Cullin 2, and impairs HIF2α ubiquitylation and degradation.
Hypoxia Promotes Cancer Stem Cells via ID2-Dependent VHL Inactivation.
New
In Cancer Discov, Feb 2016
UNASSIGNED: Hypoxia inactivates DYRK1, preventing ID2 phosphorylation and promoting CSCs and HIF2α stabilization.
Identification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma.
New
Liang et al., United States. In Cancer Res, Feb 2016
Compared to commonly mutated genes in ccRCC, such as the von Hippel-Lindau (VHL) tumor suppressor, the genes identified by AcceSssIble comprised distinct pathways and more frequently underwent epigenetic changes, suggesting that genetic and epigenetic alterations could be independent events in ccRCC.
Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF-1α and HIF-2α.
New
Frew et al., Zürich, Switzerland. In Cancer Res, Feb 2016
UNASSIGNED: The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but genetic ablation of Vhl alone in mouse models is insufficient to recapitulate human tumorigenesis.
Von Hippel-Lindau disease: an evaluation of natural history and functional disability.
New
Opocher et al., Modena, Italy. In Neuro Oncol, Feb 2016
BACKGROUND: Although many studies have been published about specific lesions characterizing von Hippel-Lindau(VHL) disease, none have dealt with the natural history of the whole disease and the consequent disabilities.
MANAGEMENT OF ENDOCRINE DISEASE: Outcome of adrenal sparing surgery in heritable pheochromocytoma.
Review
New
Sebag et al., Freiburg, Germany. In Eur J Endocrinol, Jan 2016
Bilateral pheochromocytoma does not increase mortality in MEN2 or von Hippel-Lindau (VHL) mutation carriers who are followed regularly, but these mutations induce major morbidities if total bilateral adrenalectomy is performed.
Role of RSUME in inflammation and cancer.
Review
New
Arzt et al., Buenos Aires, Argentina. In Febs Lett, Dec 2015
RSUME is induced by cellular stress like hypoxia and heat shock, and is increased in pituitary tumors, in gliomas and in VHL tumors.
Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.
Review
New
Mole et al., Erlangen, Germany. In Eur Urol, Sep 2015
Most clear cell renal cell carcinomas (ccRCC) are associated with loss of von Hippel-Lindau tumor suppressor (pVHL) function and deregulation of hypoxia pathways.
E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
New
Impact
Liu et al., Los Angeles, United States. In Immunity, Jul 2015
Here, we report that the E3 ubiquitin ligase VHL is essential for Treg cell function.
A lactate-induced response to hypoxia.
New
Impact
Yeom et al., Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
VHL, the story of a tumour suppressor gene.
Review
Impact
Maher et al., Cambridge, United Kingdom. In Nat Rev Cancer, 2015
Since the Von Hippel-Lindau (VHL) disease tumour suppressor gene VHL was identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical and scientific interest.
Molecular and immunologic markers of kidney cancer-potential applications in predictive, preventive and personalized medicine.
Review
Gratchev et al., Mannheim, Germany. In Epma J, 2014
The most common molecular markers of kidney cancer include mutations and epigenetic inactivation of von Hippel-Lindau (VHL) gene, genes of vascular endothelial growth factor (VEGF) pathway, and carbonic anhydrase IX (CIAX).
[Hereditary pheochromocytoma-associated syndromes. Part 1].
Review
Beltsevich et al., In Ter Arkh, 2014
There have been the most investigated NF, RET, VHL, SDHD, SDHC, and SDHB gene mutations.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Impact
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1).
Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability.
GeneRIF
Glover et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Codepletion of Vhl with Mgr gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes.
Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability.
GeneRIF
Hsu et al., Bologna, Italy. In Development, 2010
The results establish a developmental function of the VHL gene that is relevant to its tumor-suppressor activity.
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia.
GeneRIF
Moberg et al., Atlanta, United States. In Dev Biol, 2009
findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with developmental tracheogenesis, and identify the dVHL and ago ubiquitin ligases as key determinants of hypoxia sensitivity in tracheal cells
More papers using von Hippel-Lindau antibodies
Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors.
Supplier
Kalinichenko Vladimir V., In PLoS ONE, 2002
... Conditional VHL knockout mice were generated by crossbreeding three different transgenic mouse lines: a) floxed ...
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