Molecular evolution and functional divergence of the bestrophin protein family.
Regensburg, Germany. In Bmc Evol Biol, 2007
Most notably, significant functional divergence was found between bestrophin 4 and the other family members, as well as between bestrophin 2 and bestrophin 3. Site-specific profiles were established by posterior probability analysis revealing significantly divergent clusters mainly in two hydrophilic loops and a region immediately adjacent to the last predicted transmembrane domain.
Cloning and characterization of the murine Vmd2 RFP-TM gene family.
Würzburg, Germany. In Cytogenet Genome Res, 2003
VMD2, together with VMD2L1, VMD2L2 and VMD2L3, belong to a closely related gene family characterized by several transmembrane (TM) spanning helical domains and an invariant arginine, phenylalanine and proline (RFP) tripeptide motif, thus termed VMD2 RFP-TM.