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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Von Hippel-Lindau tumor suppressor-like

VLP
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, Phosphogluconate Dehydrogenase
Papers using VLP antibodies
Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in patients with head-and-neck squamous-cell carcinoma
Supplier
Posner M et al., In British Journal of Cancer, 1999
... =10) Abs defined by the competitive Luminex immunoassay (cLIA; VLP Ab+) developed by Merck (West Point, PA, USA) ...
Papers on VLP
Different applications of virus-like particles in biology and medicine: Vaccination and delivery systems.
Review
New
Shirbaghaee, Tehrān, Iran. In Biopolymers, Mar 2016
Up to now, several prokaryotic and eukaryotic systems such as insect, yeast, plant, and E. coli were used to express recombinant proteins, especially for VLP production.
Chemically activatable viral capsid functionalized for cancer targeting.
New
Cheng et al., Davis, United States. In Nanomedicine (lond), Feb 2016
RESULTS: LXY30-HEV VLP was checked for its binding and entry to a breast cancer cell line and for tumor targeting in vivo to breast cancer tissue in mice.
Detection of the Assembly and Disassembly of PCV2b Virus-Like Particles Using Fluorescence Spectroscopy Analysis.
New
Wan et al., Changchun, China. In Intervirology, Feb 2016
UNASSIGNED: Monitoring the assembly and disassembly of virus-like particles (VLPs) is important in developing effective VLP-based vaccines.
Functional assessment and structural basis of antibody binding to human papillomavirus capsid.
Review
New
Zhao et al., Xiamen, China. In Rev Med Virol, Jan 2016
Two prophylactic virus-like particle (VLP)-based vaccines have been marketed globally for nearly a decade.
A self-encoded capsid derivative restricts Ty1 retrotransposition in Saccharomyces.
Review
New
Purzycka et al., Athens, United States. In Curr Genet, Jan 2016
We discovered a novel truncated form of the Saccharomyces Ty1 retrotransposon capsid protein, dubbed p22 that inhibits virus-like particle (VLP) assembly and function.
Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle.
New
He et al., Guangzhou, China. In Vet Res, Dec 2015
Betanodavirus infection causes fatal disease of viral nervous necrosis in many cultured marine and freshwater fish worldwide and the virus-like particles (VLP) are effective vaccines against betanodavirus.
The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress.
New
Stahelin et al., South Bend, United States. In Sci Rep, Dec 2015
Phosphatidylserine is required for VP40 plasma membrane binding, VP40 hexamer formation, and VLP egress, However, PS also becomes exposed on the outer membrane leaflet at sites of VP40 budding, raising the question of how VP40 maintains an interaction with the plasma membrane inner leaflet when PS is flipped to the opposite side.
Functional properties of flagellin as a stimulator of innate immunity.
New
Swartz et al., Stanford, United States. In Sci Rep, Dec 2015
However, attaching the D0 domain to the VLP surface produced a stable nanoparticle adjuvant.
Recent Advancements of Treatment for Leptomeningeal Carcinomatosis.
Review
New
Lee et al., South Korea. In J Korean Neurosurg Soc, Jul 2015
Ventriculolumbar perfusion (VLP) chemotherapy has sought to increase drug delivery to the subarachnoid CSF space even in patients with disturbed CSF flow.
Next generation prophylactic human papillomavirus vaccines.
Review
New
Impact
Müller et al., Bethesda, United States. In Lancet Oncol, May 2015
The two licensed bivalent and quadrivalent human papillomavirus (HPV) L1 (the major papillomavirus virion protein) virus-like particle (VLP) vaccines are regarded as safe, effective, and well established prophylactic vaccines.
Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading.
Impact
Douglas et al., Bozeman, United States. In Nat Chem, 2012
Here we demonstrate a successful site-selective initiation of atom-transfer radical polymerization reactions to form an addressable polymer constrained within the interior cavity of a VLP.
CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
GeneRIF
Jia et al., Shanghai, China. In Diabetes, 2011
genetic association studies in a Chinese population with type 2 diabetes: An SNP in CPVL (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection.
Impact
Nabel et al., Bethesda, United States. In Nat Med, 2010
Immunization with alphavirus VLP vaccines represents a strategy to contain the spread of CHIKV and related pathogenic viruses in humans.
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
GeneRIF
Krek et al., Zürich, Switzerland. In Genes Dev, 2008
Results show pVHL as key regulators of insulin secretion from pancreatic beta cells.
The expression of hybrid HIV:Ty virus-like particles in yeast.
Impact
Kingsman et al., In Nature, 1987
These proteins include Ty-VLP structural proteins, a protease that mediates cleavage of primary translation products and a reverse transcriptase.
A vasopressin-like peptide in the mammalian sympathetic nervous system.
Impact
Michell et al., In Nature, 1984
We now report that a new bioactive and immunoreactive vasopressin-like peptide (VLP) is widely distributed in the sympathetic nervous system of mammals, both in the principal noradrenergic neurones of ganglia and in nerve fibres innervating peripheral tissues.
Review
IARC HPV Working Group, Lyon, France. In Unknown Journal, 0001
The potential of the current licensed preventive virus-like particle (VLP) human papillomavirus (HPV) vaccines to have a major public health impact is leading to additional clinical trials.
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