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Very low density lipoprotein receptor

VLDLR, VLDL receptor, very low density lipoprotein receptor
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: ApoER2, apolipoprotein E, ACID, LDL receptor, CAN
Papers using VLDLR antibodies
Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway.
Supplier
Mueller Ulrich, In PLoS ONE, 2003
... VLDLR cDNA encoding the 873 amino acids isoform A (accession # NP_003374) was cloned into pEGFP-N1 (Clontech) to generate the VLDLR-GFP ...
Papers on VLDLR
Hepatitis C virus utilizes VLDLR as a novel entry pathway.
New
Shimotohno et al., Ichikawa, Japan. In Proc Natl Acad Sci U S A, Feb 2016
In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81.
Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons.
New
Huttunen et al., Helsinki, Finland. In Exp Cell Res, Feb 2016
Similarly to BBR, subtoxic concentrations of neuronal stressors cobalt chloride, thapsigargin and rotenone increased very-low-density lipoprotein receptor (VLDLR) mRNA and protein expression in CGN suggesting a conserved pathway for stress-induced upregulation of VLDLR in neurons.
Expression of lipases and lipid receptors in sperm storage tubules and possible role of fatty acids in sperm survival in the hen oviduct.
New
Yoshimura et al., Hiroshima, Japan. In Theriogenology, Jan 2016
The expression of genes encoding very low-density lipoprotein receptor(VLDLR), low-density lipoprotein receptor (LDLR), and fatty acid translocase (FAT/CD36) were found in SST cells.
Sleeping Beauty transposon vectors in liver directed gene delivery of LDLR and VLDLR for gene therapy of familial hypercholesterolemia.
New
Ylä-Herttuala et al., Kuopio, Finland. In Mol Ther, Jan 2016
UNASSIGNED: Plasmid based Sleeping Beauty (SB) transposon vectors were developed and used to deliver genes for low-density-lipoprotein and very-low-density lipoprotein receptors (LDLR and VLDLR, respectively) or lacZ reporter into liver of an LDLR-deficient mouse model of familial hypercholesterolemia (FH).
Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.
New
Hennighausen et al., Seoul, South Korea. In Eur J Nutr, Dec 2015
The upregulation of lipoprotein lipase and Cd36 mRNA levels, an increased trend of very low-density lipoprotein receptor mRNA levels, and elevated circulating concentrations of free fatty acid, triglyceride, and total cholesterol support the increase in hepatic lipid accumulation.
Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: experimental animal models and clinical evidence.
Review
New
Ruscica et al., Padova, Italy. In Transl Res, Nov 2015
PCSK9 enhances also the degradation of LDLR's closest family members, ApoE receptor 2, very low-density lipoprotein receptor, and LDLR-related protein 1.
Genotype-phenotype correlation in neuronal migration disorders and cortical dysplasias.
Review
Kato, Yamagata, Japan. In Front Neurosci, 2014
Mutations of many genes are involved in neuronal migration disorders, such as LIS1 and DCX in classical lissencephaly spectrum, TUBA1A in microlissencephaly with agenesis of the corpus callosum, and RELN and VLDLR in lissencephaly with cerebellar hypoplasia.
Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development.
Review
Winckler et al., Charlottesville, United States. In Front Cell Neurosci, 2014
We focus our discussion on endocytic accessory proteins (EAPs) (such as numb and disabled) and how they regulate endocytosis and subsequent post-endocytic trafficking of their cognate receptors (such as Notch, TrkB, β-APP, VLDLR, and ApoER2).
Recent advances in physiological lipoprotein metabolism.
Review
Ramasamy, In Clin Chem Lab Med, 2014
Plasma remnant lipoproteins bind to specific receptors in the liver, the LDL receptor, VLDL receptor and LDL receptor-like proteins prior to removal from the plasma.
Cytoskeleton in action: lissencephaly, a neuronal migration disorder.
Review
Wynshaw-Boris et al., In Wiley Interdiscip Rev Dev Biol, 2013
Actin stress fibers are modulated by PAFAH1B1 (LIS1), DCX, RELN, and VLDLR (very low-density lipoprotein receptor)/LRP8 (low-density lipoprotein-related receptor 8, formerly known as APOER2).
Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity.
GeneRIF
Shin et al., Seoul, South Korea. In Nutrition, 2012
In the expression study, only ARG1 (4.5-fold) and VLDLR (4-fold) expressions were significantly upregulated in the overweight group compared with the normal-weight group.
Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
GeneRIF
Kalaydjieva et al., Perth, Australia. In Am J Med Genet B Neuropsychiatr Genet, 2012
Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
Copy number variation of age-related macular degeneration relevant genes in the Korean population.
GeneRIF
Seo et al., Seoul, South Korea. In Plos One, 2011
Copy number variation of VLDLR is associated with age-related macular degeneration.
FE65 as a link between VLDLR and APP to regulate their trafficking and processing.
GeneRIF
Hoe et al., Washington, D.C., United States. In Mol Neurodegener, 2011
our data suggest that FE65 serves as a link between VLDLR and APP
Pure distal 9p deletion in a female infant with cerebral palsy.
GeneRIF
Wang et al., Taipei, Taiwan. In Genet Couns, 2011
VLDLR encodes very low-dentisy lipoprotein receptor.
Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Impact
Acker-Palmer et al., Frankfurt am Main, Germany. In Nature, 2011
The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2, also known as LRP8).
Interaction of reelin signaling and Lis1 in brain development.
Impact
Clark et al., Houston, United States. In Nat Genet, 2003
Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule.
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations.
Impact
Walsh et al., Boston, United States. In Nat Genet, 2000
RELN encodes a large (388 kD) secreted protein that acts on migrating cortical neurons by binding to the very low density lipoprotein receptor (VLDLR), the apolipoprotein E receptor 2 (ApoER2; refs 9-11 ), alpha3beta1 integrin and protocadherins.
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Impact
Herz et al., Dallas, United States. In Cell, 1999
Here, we report the requirement for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2).
Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene.
Impact
Wilson et al., Philadelphia, United States. In Nat Genet, 1996
Infusion of recombinant adenoviruses containing the VLDL receptor gene corrected the dsylipidaemia in the FH mouse and circumvented immune responses to the transgene leading to a more prolonged metabolic correction.
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