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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Integrin, alpha 4

VLA-4, CD49d, Integrin alpha4
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD11b, Vascular Cell Adhesion Molecule-1, CAN, Intercellular Adhesion Molecule-1, HAD
Papers using VLA-4 antibodies
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
Supplier
Cybulsky Myron I. et al., In The Journal of Cell Biology, 2002
... Letarte, Hospital for Sick Children, Toronto, Ontario, Canada), FITC- or allophycocyanin (APC)-conjugated CD49d clone 9F10 (BioLegend), APC-conjugated anti–human CD14 clone ...
Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology
Supplier
Sklar Larry A et al., In BMC Immunology, 2000
... peptide receptor, clone 5F1, isotype control (mouse IgG1 κ PE) clone MOPC-21, PE mouse anti-human CD49d (α4-integrin subunit PE) clone 9F10 were purchased from BD Biosciences and used according to ...
Papers on VLA-4
Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance.
New
San Miguel et al., Pamplona, Spain. In Blood, Feb 2016
Here, we compared the antigenic profile of MRD vs. diagnostic clonal PCs in 40 elderly MM patients enrolled in the GEM2010MAS65 study, and showed that the MRD subclone is enriched in cells over-expressing integrins (CD11a/CD11c/CD29/CD49d/CD49e), chemokine receptors (CXCR4) and adhesion molecules (CD44/CD54).
Characterization of age-associated exhausted CD8(+) T cells defined by increased expression of Tim-3 and PD-1.
New
Kang et al., Seoul, South Korea. In Aging Cell, Feb 2016
The generation of Tim-3-expressing CD8(+) T cells in aged mice seems to be mediated by encounters with antigens but not by specific infection, based on their high expression of CD49d and their unbiased TCR Vβ usage.
Prognostic Factors for Chronic Lymphocytic Leukemia.
Review
New
Puvvada et al., Tucson, United States. In Curr Hematol Malig Rep, Feb 2016
The prognostic information can be categorized into three categories: genetic abnormalities which include 17p, 11q, and immunoglobulin heavy chain variable (IGHV) abnormalities; biochemical abnormalities and cell surface markers which include serum thymidine kinase, β-2-microglobulin, CD49d, CD38, and ZAP-70 levels; and patient characteristics which include sex, age, and performance status.
Ex vivo and in vivo evaluation of over-expressed VLA-4 in multiple myeloma using LLP2A imaging agents.
New
Shokeen et al., Washington, D.C., United States. In J Nucl Med, Feb 2016
UNASSIGNED: Very-late-antigen-4 (VLA-4, α4β1 integrin, CD49d/CD29) is a transmembrane adhesion receptor that plays important role in cancer and immune responses.
Bacteria Exposed Biliary Epithelium and Liver B Cells Activate Intrahepatic Mait Cells in an MR1-Dependent Manner.
New
Oo et al., Birmingham, United Kingdom. In J Hepatol, Jan 2016
LI-MAIT cells were also present in the hepatic sinusoids and possessed tissue-homing chemokine receptor CXCR3 and integrins LFA-1 and VLA-4, suggesting their recruitment via hepatic sinusoids.
The leukocyte-stiffening property of plasma in early acute respiratory distress syndrome (ARDS) revealed by a microfluidic single-cell study: the role of cytokines and protection with antibodies.
New
Theodoly et al., Marseille, France. In Crit Care, Dec 2015
In contrast, the measurements of integrin expression (CD11b, CD11a, CD18, CD49d) and leukocyte-endothelium adhesion showed a weak and slow response after incubation with the sera of patients with ARDS (several hours), suggesting a lesser role of leukocyte adhesiveness compared with leukocyte stiffness in early ARDS.
Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.
Review
New
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Nov 2015
Examples include Fingolimod, glatiramer acetate, and antibodies blocking the leukocyte integrin VLA-4.
Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking.
Review
New
Adamiak et al., Louisville, United States. In Leukemia, Jul 2015
These structures have an important role in assembling signaling molecules (e.g., Rac-1, RhoH and Lyn) together with surface receptors, such as the CXCR4 receptor for α-chemokine stromal-derived factor-1, the α4β1-integrin receptor (VLA-4) for vascular cell adhesion molecule-1 and the c-kit receptor for stem cell factor, which together regulate several aspects of hematopoietic stem/progenitor cell (HSPC) biology.
Targeting the microenvironment in acute myeloid leukemia.
Review
New
Uy et al., Saint Louis, United States. In Curr Hematol Malig Rep, Jun 2015
Agents currently under investigation include hypoxia-inducible agents and inhibitors of CXCR4 and adhesion molecules such as VLA-4 and E-selectin.
Early reprogramming regulators identified by prospective isolation and mass cytometry.
New
Impact
Wernig et al., Stanford, United States. In Nature, Jun 2015
Instead, in a systematic functional surface marker screen, we find that early reprogramming-prone cells express a unique set of surface markers, including CD73, CD49d and CD200, that are absent in both fibroblasts and iPS cells.
The Role of CD44 in the Pathophysiology of Chronic Lymphocytic Leukemia.
Review
Hartmann et al., Salzburg, Austria. In Front Immunol, 2014
CD44 can complex with key prognostic factors of CLL, particularly CD38 and CD49d, bridging the gap between prognosis and cellular function.
CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
Impact
Gattei et al., Novara, Italy. In J Clin Oncol, 2014
PURPOSE: Although CD49d is an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL), definitive validation evidence is lacking.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
Impact
Schwartz et al., Israel. In Immunity, 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.
Impact
Palmer et al., Basel, Switzerland. In Immunity, 2012
The ensuing proximal daughters underwent extensive division and differentiated into short-lived effector cells expressing the integrin VLA-4, allowing the activated T cell to infiltrate and mediate destruction of peripheral target tissues.
Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation.
GeneRIF
Shimoda et al., Miyazaki, Japan. In Ann Hematol, 2012
Specific adhesion of megakaryoblasts to fibronectin via both alpha4- and alpha5-integrin molecules and phorbol 12-myristate 13-acetate (PMA) is essential for pro-platelet-like formation of megakaryocytes.
The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells.
GeneRIF
Pauza et al., In Blood, 2012
Integrin alphar4beta7 binds gp120 but does not mediate HIV envelope-induced death signaling.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Impact
Lyden et al., New York City, United States. In Nat Med, 2012
In addition, we identified an exosome-specific melanoma signature with prognostic and therapeutic potential comprised of TYRP2, VLA-4, HSP70, an HSP90 isoform and the MET oncoprotein.
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.
GeneRIF
Cybulsky et al., Toronto, Canada. In J Cell Biol, 2012
The live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton.
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability.
GeneRIF
Noh et al., Seoul, South Korea. In Int J Oncol, 2012
The CD49d+/high subpopulation sorted from NDY-1 spheres displayed higher cell viability and sphere-forming ability than CD49d-/low population in vitro.
Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration.
GeneRIF
García-Ojeda et al., Merced, United States. In Plos One, 2011
The integrin subunits Itga4 (alpha4) and Itgal (Lfa1), as well as the selectin ligand Selplg (Psgl1), did not show differences in their expression in single LT-HSCs irrespective of the developmental times or anatomical microenvironments.
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