gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Group-specific component

Vitamin D-Binding Protein, Gc-globulin
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Dbp, HAD, fibrillin-1, Serum albumin, AGE
Papers on Vitamin D-Binding Protein
L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats.
New
Micinski et al., Shreveport, United States. In Mol Nutr Food Res, Feb 2016
SCOPE: Vitamin D binding protein (VDBP) status has an effect on and can potentially improve the status of 25(OH) vitamin D and increase the metabolic actions of 25(OH) vitamin D under physiological and pathological conditions.
Effects of Vitamin D Binding Protein Phenotypes and Vitamin D Supplementation on Serum Total 25(OH)D and Directly Measured Free 25(OH)D.
New
Jorde et al., Bodø, Norway. In Eur J Endocrinol, Feb 2016
OBJECTIVE: To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D, and calculated free 25(OH)D in regard to DBP phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.
Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial.
New
Coupey et al., United States. In J Pediatr, Jan 2016
Serum 25(OH)D and vitamin D binding protein (VDBP) levels were measured pre-and posttreatment; 122 (67%) participants completed posttreatment measures.
Determination of human reference values for serum total 1,25-dihydroxyvitamin D using an extensively validated 2D ID-UPLC-MS/MS method.
Review
New
Heijboer et al., Amsterdam, Netherlands. In J Steroid Biochem Mol Biol, Jan 2016
The presence of significantly higher average 1,25-dihydroxyvitamin D3 levels in premenopausal women taking oral contraceptive pills compared to postmenopausal women suggests that this effect is estrogen-related, as estrogens lead to a higher vitamin D binding protein.
Two-Dimensional Differential Gel Electrophoresis to Identify Protein Biomarkers in Amniotic Fluid of Edwards Syndrome (Trisomy 18) Pregnancies.
New
Hsiao et al., Kao-hsiung, Taiwan. In Plos One, Dec 2015
MALDI-TOF/MS identified one up-regulated protein: apolipoprotein A1 (ApoA1), and four under-regulated proteins: vitamin D binding protein (VDBP), alpha-1-antitrypsin (A1AT), insulin-like growth factor-binding protein 1 (IGFBP-1), and transthyretin (TTR).
Urinary Vitamin D Binding Protein and KIM-1 Are Potent New Biomarkers of Major Adverse Renal Events in Patients Undergoing Coronary Angiography.
New
Hocher et al., Berlin, Germany. In Plos One, Dec 2015
BACKGROUND: Vitamin-D-binding protein (VDBP) is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH) vitamin D 3/VDBP complex.
Behind the scenes of vitamin D binding protein: More than vitamin D binding.
Review
New
Speeckaert et al., Gent, Belgium. In Best Pract Res Clin Endocrinol Metab, Oct 2015
Although being discovered in 1959, the number of published papers in recent years reveals that vitamin D binding protein (DBP), a member of the albuminoid superfamily, is a hot research topic.
A novel, fully-automated, chemiluminescent assay for the detection of 1,25-dihydroxyvitamin D in biological samples.
Review
New
Bonelli et al., Burlington, United States. In J Steroid Biochem Mol Biol, Sep 2015
METHOD: The novel 1,25-(OH)2D assay was conceived based on four pillars: (1) the VDR's ligand binding domain (LBD) as a capture molecule; (2) reaction conditions wherein 1,25-(OH)2D favors binding to LBD vs. the vitamin D binding protein; (3) exploitation of liganded-LBD's conformational change; (4) a monoclonal antibody specific to liganded-LBD.
Vitamin D, Cancer Risk, and Mortality.
Review
Gandini et al., Milano, Italy. In Adv Food Nutr Res, 2014
The GC (group-specific component) gene, encoding DBP, is highly polymorphic and several polymorphisms were investigated in association with cancer development with controversial results.
Urinary biomarkers for the non-invasive diagnosis of endometriosis.
Review
Hull et al., Auckland, New Zealand. In Cochrane Database Syst Rev, 2014
Five studies evaluated the diagnostic performance of four urinary biomarkers for endometriosis, including three biomarkers distinguishing women with and without endometriosis (enolase 1 (NNE); vitamin D binding protein (VDBP); and urinary peptide profiling); and one biomarker (cytokeratin 19 (CK 19)) showing no significant difference between the two groups.
Vitamin D-binding protein and vitamin D status of black Americans and white Americans.
Impact
Thadhani et al., Bethesda, United States. In N Engl J Med, 2013
Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes.
Impact
Kestenbaum et al., Seattle, United States. In Jama, 2012
Substrate 25-hydroxyvitamin D must be converted to 1,25-dihydroxyvitamin D for full biological activity, and complex metabolic pathways suggest that interindividual variability in vitamin D metabolism may alter the clinical consequences of measured serum 25-hydroxyvitamin D. OBJECTIVE: To investigate whether common variation within genes encoding the vitamin D-binding protein, megalin, cubilin, CYP27B1, CYP24A1, and the vitamin D receptor (VDR) modify associations of low 25-hydroxyvitamin D with major clinical outcomes.
Vitamin D-binding protein (group-specific component) has decreased expression in rheumatoid arthritis.
GeneRIF
Chang et al., China. In Clin Exp Rheumatol, 2012
The decreased expression and the genetic effect of VDBP in rheumatoid arthritis suggest a novel pathogenic pathway that vitamin D contributes to the arthritic process of the disease.
Impact of circulating vitamin D binding protein levels on the association between 25-hydroxyvitamin D and pancreatic cancer risk: a nested case-control study.
GeneRIF
Albanes et al., Bethesda, United States. In Cancer Res, 2012
our findings indicate that higher DBP concentrations may sequester more 25(OH)D and reduce free 25(OH)D bioavailability
Urinary vitamin D-binding protein is elevated in patients with endometriosis.
GeneRIF
Lee et al., Seoul, South Korea. In Hum Reprod, 2012
excretion of VDBP: Data suggest that urinary VDBP levels are elevated in patients with endometriosis; however, urinary VDBP levels appear to have limited potential as diagnostic biomarker for endometriosis.
Association of Thr420Lys polymorphism in DBP gene with fat-soluble vitamins and low radial bone mineral density in postmenopausal Thai women.
GeneRIF
Preutthipan et al., Bangkok, Thailand. In Biomark Med, 2012
DBP genotypes may influence the osteoporosis bone mineral density in postmenopausal Thai women
Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling.
GeneRIF
Hewison et al., Los Angeles, United States. In Plos One, 2011
These novel mathematical models underline the importance of DBP as a determinant of vitamin D 'status' in vivo, with future implications for clinical studies of vitamin D status and supplementation.
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Impact
Willnow et al., Berlin, Germany. In Cell, 1999
We show that 25-(OH) vitamin D3 in complex with its plasma carrier, the vitamin D-binding protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin.
Vitamin D deficiency in homebound elderly persons.
Impact
Tobin et al., Baltimore, United States. In Jama, 1996
A randomly selected cohort of sunlight-deprived subjects also had serum levels of vitamin D binding protein measured.
Photosynthesis of previtamin D3 in human skin and the physiologic consequences.
Impact
Elias et al., In Science, 1980
The vitamin D-binding protein preferentially translocates the thermal product, vitamin D3, into the circulation.
share on facebooktweetadd +1mail to friends