Mallotus roxburghianus modulates antioxidant responses in pancreas of diabetic rats.
Āīzawl, India. In Acta Histochem, Feb 2016
Methanolic leaf extract of M. roxburghianus (MRME 100 and 400mg/kg) was tested in comparison with normal and alloxan diabetic rats for 28 days p.o. in terms of body and pancreatic weight, blood glucose level, antioxidant enzymes, expression of visfatin and PCNA, histopathology and histomorphometric measurements of pancreas.
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Boston, United States. In Cancer Cell, Jan 2016
Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition.
NAMPT as a Therapeutic Target against Stroke.
Shanghai, China. In Trends Pharmacol Sci, Dec 2015
Nicotinamide phosphoribosyltransferase (NAMPT), also an adipokine known as visfatin, acts via enzymatic activity to synthesize nicotinamide mononucleotide (NMN) and then to maintain homeostasis of nicotinamide adenine dinucleotide (NAD), which plays a dual role in energy metabolism and biological signaling.
Adipokines in nonalcoholic fatty liver disease.
Thessaloníki, Greece. In Metabolism, Dec 2015
Data regarding other adipokines in histologically confirmed NAFLD populations are inconclusive (e.g., resistin, visfatin, retinol-binding protein-4, chemerin) or limited (e.g., adipsin, obestatin, omentin, vaspin etc.).