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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nicotinamide phosphoribosyltransferase

visfatin, nicotinamide phosphoribosyltransferase, PBEF, Nampt
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, leptin, resistin, AGE
Papers using visfatin antibodies
Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer.
Supplier
Appanna Vasu D., In PLoS ONE, 2008
... The antibody against Nampt (PBEF1, visfatin) was from Phoenix Pharmaceuticals (Burlingame, CA, USA) ...
Evaluation of basement membrane degradation during TNF-alpha-induced increase in epithelial permeability
Supplier
Ye Shui Qing et al., In Journal of Inflammation (London, England), 2000
... Rabbit anti-human PBEF polyclonal antibody was from Bethyl Laboratories, Inc ...
Papers on visfatin
Nicotinamide phosphoribosyltransferase leukocyte overexpression in Graves' opthalmopathy.
New
Ruchała et al., Poznań, Poland. In Endocrine, Feb 2016
UNASSIGNED: To investigate the role of NAMPT/visfatin in euthyroid patients with Graves' disease without (GD) and with Graves' ophthalmopathy (GO), we analyzed NAMPT leukocyte expression and its serum concentration.
Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.
New
Pietiläinen et al., Helsinki, Finland. In J Clin Endocrinol Metab, Feb 2016
MAIN OUTCOME MEASURES: SAT mRNA expressions of SIRTs 1-7 and the rate-limiting gene in NAD(+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT) were measured by Affymetrix, and total PARP activity by ELISA kit.
Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines.
New
Babu et al., Chennai, India. In Cytokine, Feb 2016
PTB-DM or LTB-DM is characterized by diminished circulating levels of adiponectin and adipsin and/or heightened circulating levels of leptin, visfatin and PAI-1.
Mallotus roxburghianus modulates antioxidant responses in pancreas of diabetic rats.
New
Gurusubramanian et al., Āīzawl, India. In Acta Histochem, Feb 2016
Methanolic leaf extract of M. roxburghianus (MRME 100 and 400mg/kg) was tested in comparison with normal and alloxan diabetic rats for 28 days p.o. in terms of body and pancreatic weight, blood glucose level, antioxidant enzymes, expression of visfatin and PCNA, histopathology and histomorphometric measurements of pancreas.
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.
New
Sheng et al., Shanghai, China. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Nicotinamide phosphoribosyltransferase (Nampt) is an attractive therapeutic target for cancer.
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
New
Impact
Cahill et al., Boston, United States. In Cancer Cell, Jan 2016
Mutant IDH1 lowered NAD+ levels by downregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizing to NAD+ depletion via concomitant nicotinamide phosphoribosyltransferase (NAMPT) inhibition.
NAMPT as a Therapeutic Target against Stroke.
Review
New
Miao et al., Shanghai, China. In Trends Pharmacol Sci, Dec 2015
Nicotinamide phosphoribosyltransferase (NAMPT), also an adipokine known as visfatin, acts via enzymatic activity to synthesize nicotinamide mononucleotide (NMN) and then to maintain homeostasis of nicotinamide adenine dinucleotide (NAD), which plays a dual role in energy metabolism and biological signaling.
Adipokines in nonalcoholic fatty liver disease.
Review
New
Mantzoros et al., Thessaloníki, Greece. In Metabolism, Dec 2015
Data regarding other adipokines in histologically confirmed NAFLD populations are inconclusive (e.g., resistin, visfatin, retinol-binding protein-4, chemerin) or limited (e.g., adipsin, obestatin, omentin, vaspin etc.).
The role of visfatin (PBEF/Nampt) in pregnancy complications.
Review
New
Bienertová-Vašků et al., Brno, Czech Republic. In J Reprod Immunol, Nov 2015
Visfatin (PBEF/Nampt) is an adipocytokine that exerts pleiotropic effects within the human body, particularly affecting its metabolism and immunity.
Physiological and pathophysiological roles of NAMPT and NAD metabolism.
Review
New
Kiess et al., Leipzig, Germany. In Nat Rev Endocrinol, Sep 2015
Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular nicotinamide adenine dinucleotide (NAD) pool.
SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice.
New
Impact
Imai et al., Saint Louis, United States. In Cell Metab, Jun 2015
Nicotinamide phosphoribosyltransferase (NAMPT), the key NAD(+) biosynthetic enzyme, has two different forms, intra- and extracellular (iNAMPT and eNAMPT), in mammals.
The role of insulin and selected adipocytokines in patients with polycystic ovary syndrome (PCOS) - a literature review.
Review
New
Pawelczyk et al., In Ginekol Pol, Apr 2015
There are several adipokines whose role has been thoroughly investigated and many that we still know very little about, for example apein and visfatin.
P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.
Impact
McKnight et al., Dallas, United States. In Cell, 2014
This derivative was found to bind nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme involved in the conversion of nicotinamide into nicotinamide adenine dinucleotide (NAD).
Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation.
Impact
Gribben et al., London, United Kingdom. In J Clin Oncol, 2013
During multivariate analysis, a model incorporating the number and location of T cells expressing PMCH, NAMPT, and ETV1 showed prognostic significance for overall survival and for time to transformation.
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging.
Impact
Guarente et al., Cambridge, United States. In Cell, 2013
This activation comprises an amplifying circadian loop involving SIRT1, PGC-1α, and Nampt.
Visfatin/pre-B-cell colony-enhancing factor (PBEF), a proinflammatory and cell motility-changing factor in rheumatoid arthritis.
GeneRIF
Neumann et al., Bad Nauheim, Germany. In J Biol Chem, 2012
visfatin/PBEF is involved in synovial fibroblast activation by triggering fibroblast motility and promoting cytokine synthesis at central sites in RA synovium.
Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin.
GeneRIF
Li et al., Chongqing, China. In Cytokine, 2012
The aim of present study is to evaluate the effects of long-term high-fat diet on the regulation of the insulin-sensitizing fibroblast growth factor-21 (FGF-21) and visfatin in ApoE(-/-) mice.
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner.
GeneRIF
Yoo et al., Frederick, United States. In J Biol Chem, 2012
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner
Serum visfatin levels, adiposity and glucose metabolism in obese adolescents.
GeneRIF
Us et al., Eskişehir, Turkey. In J Clin Res Pediatr Endocrinol, 2012
Data show that serum visfatin levels are elevated in obese adolescents and do not change with acute changes in glucose metabolism.
Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations.
GeneRIF
Ai et al., Beijing, China. In Chin Med J (engl), 2012
Elevated circulating visfatin levels in subjects with hyperthyroidism and hypothyroidism are possibly due to an increase of visfatin mRNA expression in visceral fat.
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