Structure determination of helical filaments by solid-state NMR spectroscopy.
Braunschweig, Germany. In Proc Natl Acad Sci U S A, Feb 2016
The mitochondrial antiviral signaling protein (MAVS) is a central signal transduction hub in innate immunity that is activated by a receptor-induced conversion into helical superstructures (filaments) assembled from its globular caspase activation and recruitment domain.
The catcher in the RIG-I.
Gießen, Germany. In Cytokine, Nov 2015
Activated RIG-I switches into a conformation that locks the ligand RNA and signals via the MAVS-IRF-3 axis, resulting in the upregulation of antiviral interferons.
MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.
Dallas, United States. In Science, 2015
These RNAs are detected via a mitochondrial antiviral signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production.