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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Radical S-adenosyl methionine domain containing 2

Viperin, cig5, Best5, RSAD2
protein involved in bone formation [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: ISG15, 18 U, CAN, V1a, ACID
Papers on Viperin
Identification and functional characterization of viperin of amphioxus Branchiostoma japonicum: Implications for ancient origin of viperin-mediated antiviral response.
New
Zhang et al., Qingdao, China. In Dev Comp Immunol, Dec 2015
Viperin, an antiviral protein, has been shown to be active against a wide range of DNA and RNA viruses, but no information is available regarding functional characterization of viperin in invertebrate species.
Early protein ORF086 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in mandarin fish Siniperca chuatsi.
New
Wu et al., Guangzhou, China. In Fish Shellfish Immunol, Oct 2015
Transcriptional analysis of non-specific and specific immune related genes revealed that the expression levels of IRF-7, IRAK1, Mx, Viperin, and IgM were strongly up-regulated in the vaccinated groups post-immunization.
Global transcriptomic profiling of bovine endometrial immune response in vitro. II. Effect of bovine viral diarrhea virus on the endometrial response to lipopolysaccharide.
New
Wathes et al., United Kingdom. In Biol Reprod, Oct 2015
Top down-regulated genes were RSAD2, ISG15, BST2, MX2, OAS1, USP18, IFIT3, IFI27, SAMD9, IFIT1, and DDX58, whereas TRIM56, C3, and OLFML1 were most up-regulated.
Global transcriptomic profiling of bovine endometrial immune response in vitro. I. Effect of lipopolysaccharide on innate immunity.
New
Wathes et al., United Kingdom. In Biol Reprod, Oct 2015
Cytokines and chemokines (IL1A, CX3CL1, CXCL2, and CCL5), interferon (IFN)-stimulated genes (RSAD2, MX2, OAS1, ISG15, and BST2), and the acute phase molecule SAA3 were the most up-regulated genes.
HCV dsRNA-Activated Macrophages Inhibit HCV Replication in Hepatocytes.
New
Ho et al., Shanghai, China. In Hepat Mon, Aug 2015
The role of type I IFN in macrophages-mediated anti-HCV activity is further supported by the observation that HCV dsRNA-activated macrophages SN treatment induced the expression of several IFN-stimulated genes (ISGs), ISG15, ISG56, OAS-1, OAS-2, MxA and Viperin in HCV-infected Huh7 cells.
[Progress in studies of viperin, an important cellular antiviral factor].
Review
Zhou et al., In Bing Du Xue Bao, 2015
Viperin is an endoplasmic reticulum (ER)-associated protein that has been identified as an innate antiviral protein.
Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes.
Qu et al., Harbin, China. In Front Microbiol, 2014
Overexpression of ISG15 and Viperin inhibited virus replication, and knockdown of either enhanced virus replication.
The role of viperin in the innate antiviral response.
Review
Beard et al., Adelaide, Australia. In J Mol Biol, 2014
Recent work has highlighted the importance of the host antiviral protein viperin in this process, with its ability to limit a large variety of viral infections as well as play a role in the production of type I interferon and the modulation of a number of transcription factor binding sites.
Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses.
Impact
Diamond et al., Saint Louis, United States. In Nat Med, 2013
By transducing cortical neurons with genes that were expressed more highly in granule cell neurons, we identified three interferon-stimulated genes (ISGs; Ifi27, Irg1 and Rsad2 (also known as Viperin)) that mediated the antiviral effects against different neurotropic viruses.
[Nucleic acids recognition by innate immunity].
Review
Kawai et al., Ōsaka, Japan. In Uirusu, 2012
We showed that the IFN-inducible antiviral protein Viperin promoted TLR7- and TLR9-mediated production of type I IFN by pDCs.
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
GeneRIF
Chow et al., Singapore, Singapore. In J Gen Virol, 2012
The viperin-deficient mouse model indicated that absence of viperin enhanced neither the viral load nor pulmonary damage in the lungs.
Viperin, a key player in the antiviral response.
Review
GeneRIF
Pruijn et al., Nijmegen, Netherlands. In Microbes Infect, 2012
Viperin is now known to act in different ways in the inhibition of the replication of different viruses that employ different mechanisms and organelles in their replication cycle. [Review]
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.
GeneRIF
Yuan et al., Shanghai, China. In J Gen Virol, 2012
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein VAP-33.
Viperin: a multifunctional, interferon-inducible protein that regulates virus replication.
Review
Cresswell et al., New Haven, United States. In Cell Host Microbe, 2012
Viperin is an interferon-inducible protein that inhibits the replication of a variety of viruses by apparently diverse mechanisms.
The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin.
GeneRIF
Chattopadhyay et al., Calcutta, India. In Plos One, 2011
Viperin is an alpha-beta protein containing iron-sulfur cluster at the center pocket.
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
GeneRIF
Beard et al., Adelaide, Australia. In Hepatology, 2011
We propose that viperin interacts with NS5A and the host factor, VAP-A, to limit hepatitis C virus replication at the replication complex.
Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.
Impact
GeneRIF
Cresswell et al., New Haven, United States. In Science, 2011
study shows human cytomegalovirus (HCMV)-induced viperin disrupts cellular metabolism to enhance infectious process; viperin interaction with vMIA resulted in viperin relocalization from endoplasmic reticulum to mitochondria
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Impact
Akira et al., Suita, Japan. In Immunity, 2011
We showed that the IFN-inducible antiviral protein Viperin promoted TLR7- and TLR9-mediated production of type I IFN by pDCs.
Viperin links lipid bodies to immune defense.
Impact
Chen et al., Dallas, United States. In Immunity, 2011
Viperin is an interferon-stimulated gene that exerts antiviral effects.
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