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Villin 1

vIL, VIL1
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-10, Interleukin-6, CAN, Barr, ACID
Papers using vIL antibodies
A membrane-bound matrix-metalloproteinase from Nicotiana-tabacum cv. BY-2 is induced by bacterial pathogens
Supplier
Schillberg Stefan et al., In BMC Biotechnology, 2008
... Analysis of vIL-10 accumulation levels in transgenic tobacco plants revealed a striking ...
Papers on vIL
Functional roles of a predicted branched chain aminotransferase encoded by the LkBAT1 gene of the yeast Lachancea kluyveri.
New
Riego-Ruiz et al., San Luis Potosí, Mexico. In Fungal Genet Biol, Dec 2015
To determine the function of these putative BCATs, L. kluyveri mutant strains lacking LkBAT1, LkBAT1bis or both genes were generated and tested for VIL metabolism.
Effect of ORF119 gene deletion on the replication and virulence of orf virus.
New
Chen et al., In Acta Virol, Sep 2015
Relative transcriptional levels of virulence genes OVIFNR, GIF, VEGF and VIL-10 of ORFV-Δ119-LacZ deletion virus were slightly but not significantly lower after 24 hr compared with the wtORF-SHZ1 virus.
Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1.
Yarchoan et al., Bethesda, United States. In J Virol, 2014
KSHV viral interleukin-6 (vIL-6), an analog of human IL-6, is usually lytic; production of vIL-6 by involved plasmablasts is a central feature of KSHV-MCD.
Krüppel-Like Factor 5 Promotes Epithelial Proliferation and DNA Damage Repair in the Intestine of Irradiated Mice.
Zhang et al., Suzhou, China. In Int J Biol Sci, 2014
Mice with intestinal-specific knockdown of KLF5 (Vil-Cre; Klf5(fl/+) mice) were generated and their response to radiation was compared with controls.
Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration.
Damania et al., Chapel Hill, United States. In Mbio, 2014
A viral homolog of human interleukin-6 (hIL-6) named viral interleukin-6 (vIL-6) is encoded by KSHV and expressed in KSHV-associated cancers.
Contribution of viral mimics of cellular genes to KSHV infection and disease.
Review
Tosato et al., Suita, Japan. In Viruses, 2014
For example, viral IL-6 (vIL-6) is sufficiently different from human IL-6 to activate gp130 signaling independent of the α subunit.
IL-10 encoded by viruses: a remarkable example of independent acquisition of a cellular gene by viruses and its subsequent evolution in the viral genome.
Review
Vanderplasschen et al., Liège, Belgium. In J Gen Virol, 2014
Other viruses encode functional orthologues of cIL-10, called viral IL-10s (vIL-10s).
Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.
Review
Nicholas et al., Baltimore, United States. In Recent Results Cancer Res, 2013
These proteins include viral interleukin-6 (vIL-6), viral chemokines (vCCLs), viral G protein-coupled receptor (vGPCR), viral interferon regulatory factors (vIRFs), and viral antiapoptotic proteins homologous to FLICE (FADD-like IL-1β converting enzyme)-inhibitory protein (FLIP) and survivin.
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.
GeneRIF
Xie et al., Houston, United States. In Gastroenterology, 2012
Villin-Cre(+);Klf4(fl/fl) have greater susceptibility to chemical-induced gastric carcinogenesis and increased rates of gastric tumor progression than control mice.
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.
Review
Tosato et al., Bethesda, United States. In J Interferon Cytokine Res, 2011
Viral interleukin-6 (vIL-6) is a product of Kaposi's sarcoma-associated herpesvirus (KSHV) expressed in latently infected cells and to a higher degree during viral replication.
Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3.
GeneRIF
Ariga et al., Sapporo, Japan. In Clin Immunol, 2011
identified villin, an actin-binding protein, as the 95 kDa antigen in four of five sera from patients with IPEX syndrome
Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion.
GeneRIF
Bond et al., United States. In Am J Physiol Renal Physiol, 2011
The data establish that meprins interact with and cleave villin and actin, and these cytoskeletal proteins are substrates for meprins.
Villin1, a diagnostic marker for endometrial adenocarcinoma with high grade nuclear atypia.
GeneRIF
Imai et al., Chiba, Japan. In Cancer Biol Ther, 2011
study confirmed finding of VIL1 as a diagnostic marker of cervical adenocarcinoma
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization.
Review
Rose-John et al., Kiel, Germany. In Eur J Cell Biol, 2011
Viral Interleukin-6 (vIL-6) is encoded by Human herpes virus 8 (HHV8), also known as Kaposi's sarcoma (KS)-associated herpes virus (KSHV).
Villin1, a novel diagnostic marker for cervical adenocarcinoma.
GeneRIF
Imai et al., Chiba, Japan. In Cancer Biol Ther, 2009
identified VIL1 as a novel biomarker of cervical adenocarcinoma
Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival.
Impact
McIntosh et al., Vancouver, Canada. In Nat Med, 2006
Expression of the gene encoding viral interleukin-10 (vIL-10), was measurable in real time with PET scanning.
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.
Impact
Reitz et al., Baltimore, United States. In Nat Med, 1997
We show that the HHV-8-encoded IL-6 homologue (vIL-6) shares functional properties with endogenous IL-6 proteins and that both vIL-6 and vMIP-1 transcripts are present at high levels following butyrate induction of an HHV-8' BCBL cell line.
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.
Impact
Chang et al., New York City, United States. In Science, 1997
vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions.
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor.
Impact
Spriggs et al., Seattle, United States. In Immunity, 1995
We propose to call these molecules IL-17, vIL-17, and IL-17R, respectively.
Interleukin-10.
Review
Impact
Mosmann et al., Palo Alto, United States. In Annu Rev Immunol, 1992
The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction.
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