A lactate-induced response to hypoxia.
Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
VHL, the story of a tumour suppressor gene.
Cambridge, United Kingdom. In Nat Rev Cancer, 2015
VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation.
Von Hippel-Lindau disease.
More papers using
Bethesda, United States. In Handb Clin Neurol, 2014
von Hippel-Lindau (VHL) disease is an inheritable condition with an incidence of 1 in 36000 live births.