Role of RSUME in inflammation and cancer.
Buenos Aires, Argentina. In Febs Lett, Dec 2015
RSUME is induced by cellular stress like hypoxia and heat shock, and is increased in pituitary tumors, in gliomas and in VHL tumors.
A lactate-induced response to hypoxia.
Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
VHL, the story of a tumour suppressor gene.
Cambridge, United Kingdom. In Nat Rev Cancer, 2015
VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation.
Von Hippel-Lindau Syndrome.
More papers using
Lublin, Poland. In Horm Res Paediatr, 2014
The syndrome is caused by inactivation of the VHL protein (pVHL) and increased production of VEGF, PDGF, and TGF-α.