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Dual specificity phosphatase 8

VH5, hVH-5, DUSP8
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: VH3, MKP-1, CAN, Typ, POLYMERASE
Papers on VH5
Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.
Zhang et al., Zhengzhou, China. In Pharm Biol, Nov 2015
RESULTS AND CONCLUSION: DMU-212 was found to regulate a diverse range of genes, including cytokines (IL8, selectin E, MPZL2, EGR1, CCL20, ITGB8, CXCL1, VCAM1, KITLG, and AREG), transport proteins (TRPC4, SLC41A2, SLC17A5, and CREB5), metabolism (CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other genes with unknown function (PGM5P2, SNORD1142, LOC151760, KRTAP5-2, C1orf110, SNORA14A, MIR31, C2CD4B, SCARNA4, C2orf66, SC4MOL, LOC644714, and LOC283392).
Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8.
Rosenblum et al., Toronto, Canada. In J Am Soc Nephrol, Oct 2015
Six genes with expression in ureteric tip cells, including Wnt11, were downregulated, whereas the expression of dual-specificity phosphatase 8 (DUSP8) was upregulated.
Micro-RNA 21Targets dual specific phosphatase 8 to promote collagen synthesis in high glucose-treated primary cardiac fibroblasts.
Chen et al., Guangzhou, China. In Can J Cardiol, 2014
A luciferase reporter assay was used to verify the interaction between miR-21 and the 3' untranslated region (3'UTR) of dual specific phosphatase 8 (DUSP8).
Draft Genome Sequences of the Fish Pathogen Vibrio harveyi Strains VH2 and VH5.
Katharios et al., Copenhagen, Denmark. In Genome Announc, 2014
Here, we announce the draft genome sequences of V. harveyi strains VH2 and VH5, isolated from farmed juvenile Seriola dumerili during outbreaks of vibriosis in Crete, Greece.
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Guo et al., Nanjing, China. In Int J Neurosci, 2013
The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi.
Cross-neutralizing activity of human anti-V3 monoclonal antibodies derived from non-B clade HIV-1 infected individuals.
Gorny et al., New York City, United States. In Virology, 2013
Interestingly, superior neutralizing activity of Cameroonian mAbs was also observed among the nine VH5-51/VL lambda genes encoding V3 mAbs which mediate a similar mode of recognition.
Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
Ling et al., Malmö, Sweden. In Diabetologia, 2013
Successful DNA methylation data were generated for 16 of these 19 CpG-SNP loci, representing the candidate genes TCF7L2, KCNQ1, PPARG, HHEX, CDKN2A, SLC30A8, DUSP9, CDKAL1, ADCY5, SRR, WFS1, IRS1, DUSP8, HMGA2, TSPAN8 and CHCHD9.
Differential regulation of M3/6 (DUSP8) signaling complexes in response to arsenite-induced oxidative stress.
Panayotou et al., Greece. In Cell Signal, 2013
M3/6 (DUSP8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of JNK and, to a lesser extent, p38 MAPKs and is found in a complex with these kinases, along with other pathway components, held together by scaffold proteins.
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Chan et al., Stanford, United States. In J Cereb Blood Flow Metab, 2013
Furthermore, we observed that rosiglitazone increased expression of the dual-specificity phosphatase 8 (DUSP8) protein and messenger RNA in ischemic brain tissue.
Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics.
Yoshino et al., Okayama, Japan. In Mod Pathol, 2013
The number of immunoglobulin heavy-chain variable domains VH4 and VH5 were higher in duodenal follicular lymphomoas than in gastric FLs.
Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions.
Murali et al., Blacksburg, United States. In Bmc Microbiol, 2012
These processes contained both immune response-inducing genes such as MALT1, SERPINE1, ICAM1, and IL8, and immune response-repressing genes such as DUSP8, DUSP6, and SPRED2.
Phosphorylation of the M3/6 dual-specificity phosphatase enhances the activation of JNK by arsenite.
Panayotou et al., Greece. In Cell Signal, 2012
The phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Keyse, Dundee, United Kingdom. In Cancer Metastasis Rev, 2008
The final group consists of three MKPs DUSP8/hVH-5, DUSP10/MKP-5 and DUSP16/MKP-7 all of which preferentially inactivate the stress-activated p38 and JNK MAP kinases.
Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.
Ullrich et al., Martinsried, Germany. In Cancer Genet Cytogenet, 2005
Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5.
Investigation of DUSP8 and CALCA in alcohol dependence.
Sikela et al., Denver, United States. In Addict Biol, 2003
DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5
B cell superantigens in HIV-1 infection.
Köhler et al., Lexington, United States. In Int Rev Immunol, 1996
Polyclonal and monoclonal (VH1, VH4, and VH5) anti-p24 and gp120 antibodies share a crossreactive idiotype (IF7).
Immunogenetics of human IgE.
Stevenson et al., Southampton, United Kingdom. In Hum Antibodies Hybridomas, 1995
First, preferential choice of VH genes, with dominance of the small VH5 family, particularly the VH32 gene, has been found.
Malignant CD5 B cells--biased immunoglobulin variable gene usage and autoantibody production.
Bona et al., New York City, United States. In Int Rev Immunol, 1990
A statistically significant biased usage of the VH5, VH6 and VKIII immunoglobulin variable gene families was observed.
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