gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dual specificity phosphatase 5

VH3, DUSP5
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MKP-1, IgM, HAD, CAN, ACID
Papers on VH3
Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress.
New
Fent et al., Muttenz, Switzerland. In Aquat Toxicol, Feb 2016
Furthermore, strong transcriptional changes occurred for tumor necrosis factor alpha (tnfa) and dual specificity phosphatase 5 (dusp5), associated with mitogen activated protein kinase (MAPK) pathway.
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
New
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
Enhanced production of naïve T cells improved the T-cell receptor (TCR) repertoire diversity and re-established a pool of T cells exhibiting higher levels of miR-181a and diminished amounts of the TCR-inhibiting phosphatases SHP-2 and DUSP5/6.
Understanding ForteBio's Sensors for High-Throughput Kinetic and Epitope Screening for Purified Antibodies and Yeast Culture Supernatant.
New
Estep et al., United States. In J Biomol Screen, Jan 2016
However, the interaction between ProA sensors and the Fab region of the IgG with VH3 germline limited the application of ProA sensors, especially in the epitope binning experiment.
MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5.
New
Li et al., Hefei, China. In Int J Biol Macromol, Jan 2016
We report that MeCP2 modulates cardiac fibrosis via down-regulation of dual-specificity phosphatase 5 (DUSP5), a nuclear phosphatase that negatively regulates prohypertrophic signaling by ERK1/2.
Information Transfer in Gonadotropin-Releasing Hormone (GnRH) Signaling: Extracellular Signal-Regulated Kinase (ERK)-Mediated Feedback Loops Control Hormone Sensing.
New
McArdle et al., Bristol, United Kingdom. In J Biol Chem, Jan 2016
Consistent with this, experiments revealed that reducing negative feedback (by expressing catalytically inactive ERK2) and increasing negative feedback (by Egr1-driven expression of dual-specificity phosphatase 5 (DUSP5)) both reduced information transfer from GnRHR to ERK.
Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia.
New
Choi et al., Seoul, South Korea. In Biochem Biophys Res Commun, Dec 2015
LPS induced expression of DUSP1, DUSP2, and DUSP5 within 60 min, whereas DUSP4 expression was induced more slowly.
Diffuse large B-cell lymphoma of the testis relapsed 16 years after achieving complete response.
Handa et al., In Rinsho Ketsueki, 2014
VH3-21 was detected in lymphoma cells at the times of both the first diagnosis and the relapse based on analysis of the variable region of the immunoglobulin heavy chain.
Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor.
Groussin et al., Paris, France. In Plos One, 2014
Serum stimulation of mammalian cells induces, via the MAPK pathway, the nuclear protein DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the ERK1/2 MAP kinases.
[Bacteria and viruses modulate FcεRI-dependent mast cell activity].
Review
Brzezińska-Błaszczyk et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2012
What is more, some bacterial and viral components or some endogenous proteins produced during viral infection can act as superantigens by interacting with the VH3 domain of IgE.
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.
Review
Martelli et al., Greenville, United States. In Oncotarget, 2012
Certain components of these pathways, RAS, NF1, BRAF, MEK1, DUSP5, PP2A, PIK3CA, PIK3R1, PIK3R4, PIK3R5, IRS4, AKT, NFKB1, MTOR, PTEN, TSC1, and TSC2 may also be activated/inactivated by mutations or epigenetic silencing.
Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics.
GeneRIF
Lane et al., Salt Lake City, United States. In Physiol Genomics, 2011
Intrauterine growth retardation affects hippocampal DUSP5 expression and epigenetic characteristics in a sex-specific manner.
Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester.
GeneRIF
Pulido et al., Valencia, Spain. In J Biol Chem, 2010
the differential up-regulation of MKP3 by Ets2 and of DUSP5 by c-Jun may converge in similar functional roles for these MAP kinase phosphatases in the growth arrest versus proliferation decisions of breast cancer cells
Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5.
GeneRIF
Bourette et al., Villeurbanne, France. In J Leukoc Biol, 2010
After SSH between cDNA libraries from FD-Fms cells stimulated by M-CSF in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2.
DUSP5 and DUSP6 modulate corneal epithelial cell proliferation.
GeneRIF
Wolosin et al., New York City, United States. In Mol Vis, 2009
DUSP5 and DUSP6 selectively control ERK pathway activity and proliferation.
Immunoglobulins, antibody repertoire and B cell development.
Review
Kacskovics et al., Iowa City, United States. In Dev Comp Immunol, 2009
Swine differ from rodents and primates, but are similar to rabbits in using a single VH family (VH3) to encode their variable heavy chain domain, but not the family used by cattle, another artiodactyl.
Dusp-5 and Snrk-1 coordinately function during vascular development and disease.
GeneRIF
Ramchandran et al., Milwaukee, United States. In Blood, 2009
Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Review
Keyse, Dundee, United Kingdom. In Cancer Metastasis Rev, 2008
The first comprises DUSP1/MKP-1, DUSP2/PAC1, DUSP4/MKP-2 and DUSP5/hVH-3, which are inducible nuclear phosphatases.
Role of superallergens in allergic disorders.
Review
Spadaro et al., Napoli, Italy. In Chem Immunol Allergy, 2006
We found that protein Fv, an endogenous protein synthesized in the human liver and increased during viral hepatitis, act as a superallergen by binding to IgE of the VH3 family and activating human basophils and mast cells.
Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regions.
Impact
Conley et al., Memphis, United States. In Immunity, 2001
These unusual mu heavy chains demonstrate preferential use of certain VH genes (VH3-23), frequent expression of DH regions in underrepresented reading frames, and an increased number of positively charged amino acids within the CDR3 region.
Immunoglobulin VH3 gene products: natural ligands for HIV gp120.
Impact
Braun et al., Los Angeles, United States. In Science, 1993
Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products.
share on facebooktweetadd +1mail to friends