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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Solute carrier family 32

VGAT, VIAAT
integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Rdl, ACID, VGLUT1, CAN, Glutamate Decarboxylase
Papers using VGAT antibodies
GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor.
Supplier
Manzoni Olivier Jacques, In PLoS ONE, 2006
... Experimental animals were obtained by mating female C57BL/6 mice with hemizygous male VGAT-Venus transgenic mice ...
Synaptic inhibition of pyramidal cells evoked by different interneuronal subtypes in layer v of rat visual cortex
Supplier
Kaneko Takeshi et al., In Frontiers in Neural Circuits, 2001
... Fifty-six VGAT-Venus transgenic B line rats (Uematsu et ...
Cortical amino acidergic pathways in Alzheimer's disease
Supplier
DeFelipe Javier et al., In Frontiers in Neuroanatomy, 1986
... monoclonal antibodies: GABA transporter 1 (GAT-1, 1:500, AB1570: Chemicon International, Temecula, CA, USA); vesicular GABA transporter (VGAT, 1:2,000, 131003: Synaptic Systems, Goettingen, Germany); vesicular glutamate ...
Papers on VGAT
The plastic neurotransmitter phenotype of the hippocampal granule cells and of the moss in their messy fibers.
New
Gutiérrez, Mexico. In J Chem Neuroanat, Jan 2016
Indeed, the GCs somata and their mossy fibers express in a regulated manner glutamate and GABA, GAD, VGlut and VGAT, all markers of both phenotypes.
Microconnectomics of the pretectum and ventral thalamus in the chicken (Gallus gallus).
New
Luksch et al., Freising, Germany. In J Comp Neurol, Jan 2016
All neurons in the GLv showed strong expression of the vesicular inhibitory amino acid transporter (VIAAT) mRNA, suggesting a GABAergic identity.
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
New
Moon et al., Kwangju, South Korea. In Int J Dev Neurosci, Dec 2015
During postnatal development, the mRNA levels of GABA A receptor (GABAAR) subunits, including α1, α4, β1, β2, and δ; GABA B receptor (GABABR) subunit 2; and the expression of GABA-related proteins, including glutamic acid decarboxylase, vesicular GABA transporter (VGAT), and potassium chloride cotransporter 2 increased gradually in the mouse hippocampus.
Selective expression of a constitutively active erythropoietin receptor in GABAergic neurons alters hippocampal network properties without affecting cognition.
New
Wojcik et al., Egypt. In J Neurochem, Dec 2015
We generated transgenic mice that express cEPOR under the control of the vesicular inhibitory amino acid transporter (Viaat) promoter and subjected them to comprehensive behavioral, cognitive and electrophysiological analyses.
High-Frequency Stimulation at the Subthalamic Nucleus Suppresses Excessive Self-Grooming in Autism-Like Mouse Models.
New
Reti et al., Baltimore, United States. In Neuropsychopharmacology, Dec 2015
To explore the feasibility of deep brain stimulation (DBS) for intractable SIB seen in some patients with an ASD, we utilized two genetically distinct mouse models demonstrating excessive self-grooming, namely the Viaat-Mecp2(-/y) and Shank3B(-/-) lines, and administered high-frequency stimulation (HFS) via implanted electrodes at the subthalamic nucleus (STN-HFS).
Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins in Adult Rat Visual Cortex(1,2,3).
New
Murphy et al., Hamilton, Canada. In Eneuro, Nov 2015
To test this we studied the effect of fluoxetine treatment in adult rats, alone or in combination with visual deprivation [monocular deprivation (MD)], on a set of highly conserved presynaptic and postsynaptic proteins (synapsin, synaptophysin, VGLUT1, VGAT, PSD-95, gephyrin, GluN1, GluA2, GluN2B, GluN2A, GABAAα1, GABAAα3).
Thirst driving and suppressing signals encoded by distinct neural populations in the brain.
New
Impact
Zuker et al., New York City, United States. In Nature, May 2015
In contrast, activation of a second population of subfornical organ neurons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking, even in water-craving thirsty animals.
KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.
Kasinathan et al., Newark, United States. In Mol Vis, 2014
Cells in the eye lens express at least 13 GABA receptor subunits, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl D-aspartate (NMDA) glutamate receptors, GAD1/GAD2, GAT1-4 and vGAT, and NKCC1.
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Review
Fredriksson et al., Uppsala, Sweden. In Mol Aspects Med, 2013
The most well characterized genes within these families are the vesicular inhibitory amino acid transporter (VIAAT, SLC32A1), PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4).
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Review
Smolders et al., Brussels, Belgium. In Front Cell Neurosci, 2012
We will first describe the current knowledge on vesicular glutamate transporters (VGLUT1/2/3), the vesicular excitatory amino acid transporter (VEAT), the vesicular nucleotide transporter (VNUT), vesicular monoamine transporters (VMAT1/2), the vesicular acetylcholine transporter (VAChT) and the vesicular γ-aminobutyric acid (GABA) transporter (VGAT) in the brain.
Dopaminergic neurons inhibit striatal output through non-canonical release of GABA.
Impact
Sabatini et al., Boston, United States. In Nature, 2012
GABA is released directly from dopaminergic axons but in a manner that is independent of the vesicular GABA transporter VGAT.
Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons.
GeneRIF
Liposits et al., Budapest, Hungary. In Endocrinology, 2012
Data indicate that GABAergic axons were labeled with vesicular inhibitory aa transporter (VIAAT) antibodies, whereas glutamatergic axons were detected with antisera against the major vesicular glutamate transporter (VGLUT) isoforms, VGLUT1 and VGLUT2.
Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT).
GeneRIF
Saito et al., Maebashi, Japan. In Mol Pharmacol, 2012
results provide genetic, behavioral, and electrophysiological evidence that VGAT-mediated inhibitory drive alters very specific forms of sensory processing: those related to pain processing
Expression of VGluT1 and VGAT mRNAs in human dorsolateral prefrontal cortex during development and in schizophrenia.
GeneRIF
Weicker et al., Sydney, Australia. In Brain Res, 2011
We examined the ratio of excitatory to inhibitory vesicular neurotransmitter transporter mRNAs (VGluT1 to VGAT) and their ratio in the dorsolateral prefrontal cortex during normal human development and in people with schizophrenia
Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice.
GeneRIF
Condie et al., Athens, United States. In Plos One, 2009
Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice
The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice.
GeneRIF
Yanagawa et al., Maebashi, Japan. In Mol Brain, 2009
Results suggest that the vesicular GABA transporter VGAT is fundamental for the GABA- and/or glycine-mediated transmission that supports embryonic development.
A novel mechanism for GABA synthesis and packaging into synaptic vesicles.
Review
Wu et al., Boca Raton, United States. In Neurochem Int, 2009
Here, we present new evidence of the presence of GAD65 associated with mitochondria in the axon terminal and project a model in which ATP generated by mitochondrial GAD65 may serve an important function in providing energy for GAD65 mediated GABA biosynthesis and packaging into synaptic vesicles by vesicular GABA transporter (VGAT).
Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight.
Review
Meister, Stockholm, Sweden. In Physiol Behav, 2007
The majority of the neurons located in the ventromedial aspect of the arcuate nucleus, which produce the orexigenic peptides neuropeptide Y (NPY) and agouti-related peptide (AGRP), contain in addition the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD) and the vesicular GABA transporter (VGAT), thereby supporting their GABAergic nature.
Functional significance of co-localization of GABA and Glu in nerve terminals: a hypothesis.
Review
Somogyi, Oxford, United Kingdom. In Curr Top Med Chem, 2005
Experimental data have been accumulating which demonstrate; i) GABA-immunoreactivity in and GABA-release from constitutively Gluergic hippocampal mossy fibre terminals, ii) plasticity of the GABAergic phenotype of constitutively Gluergic granule cells of the Dentate Gyrus, iii) expression of GABA(A) receptor gamma(3) subunit in the mossy fibre termination zone in the CA3 subfield, iv) co-labeling of terminals for GABA and Glu in the retina, brain stem and spinal cord, and v) functional compatibility of vesicular Glu (VGLUT3) and GABA (VIAAT) transporters.
Identification and characterization of the vesicular GABA transporter.
Impact
Jorgensen et al., San Francisco, United States. In Nature, 1997
Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for monoamines shows that there are differences in the bioenergetic dependence of transport, and these presumably account for the differences in structure.
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