Cortical amino acidergic pathways in Alzheimer's disease
In Frontiers in Neuroanatomy, 1986
... monoclonal antibodies: GABA transporter 1 (GAT-1, 1:500, AB1570: Chemicon International, Temecula, CA, USA); vesicular GABA transporter (VGAT, 1:2,000, 131003: Synaptic Systems, Goettingen, Germany); vesicular glutamate ...
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
Kwangju, South Korea. In Int J Dev Neurosci, Dec 2015
During postnatal development, the mRNA levels of GABA A receptor (GABAAR) subunits, including α1, α4, β1, β2, and δ; GABA B receptor (GABABR) subunit 2; and the expression of GABA-related proteins, including glutamic acid decarboxylase, vesicular GABA transporter (VGAT), and potassium chloride cotransporter 2 increased gradually in the mouse hippocampus.
Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins in Adult Rat Visual Cortex(1,2,3).
Hamilton, Canada. In Eneuro, Nov 2015
To test this we studied the effect of fluoxetine treatment in adult rats, alone or in combination with visual deprivation [monocular deprivation (MD)], on a set of highly conserved presynaptic and postsynaptic proteins (synapsin, synaptophysin, VGLUT1, VGAT, PSD-95, gephyrin, GluN1, GluA2, GluN2B, GluN2A, GABAAα1, GABAAα3).
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Uppsala, Sweden. In Mol Aspects Med, 2013
The most well characterized genes within these families are the vesicular inhibitory amino acid transporter (VIAAT, SLC32A1), PAT1 (SLC36A1), PAT2 (SLC36A2), PAT4 (SLC36A4), SNAT1 (SLC38A1), SNAT2 (SLC38A2), SNAT3 (SLC38A3), and SNAT4 (SLC38A4).
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Brussels, Belgium. In Front Cell Neurosci, 2012
We will first describe the current knowledge on vesicular glutamate transporters (VGLUT1/2/3), the vesicular excitatory amino acid transporter (VEAT), the vesicular nucleotide transporter (VNUT), vesicular monoamine transporters (VMAT1/2), the vesicular acetylcholine transporter (VAChT) and the vesicular γ-aminobutyric acid (GABA) transporter (VGAT) in the brain.
A novel mechanism for GABA synthesis and packaging into synaptic vesicles.
Boca Raton, United States. In Neurochem Int, 2009
Here, we present new evidence of the presence of GAD65 associated with mitochondria in the axon terminal and project a model in which ATP generated by mitochondrial GAD65 may serve an important function in providing energy for GAD65 mediated GABA biosynthesis and packaging into synaptic vesicles by vesicular GABA transporter (VGAT).
Identification and characterization of the vesicular GABA transporter.
San Francisco, United States. In Nature, 1997
Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for monoamines shows that there are differences in the bioenergetic dependence of transport, and these presumably account for the differences in structure.