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Vezatin, adherens junctions transmembrane protein
vezatin
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] (from
NCBI)
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Top mentioned proteins:
Actin, E-cadherin, HAIR, CAN, OUT
Papers on
vezatin
Discovery of a vezatin-like protein for dynein-mediated early endosome transport.
New
London, United Kingdom. In Mol Biol Cell, Dec 2015
Here our forward genetic study led to the discovery of VezA, a vezatin-like protein in Aspergillus nidulans, as a factor critical for early endosome distribution.
Replication and meta-analysis of previous genome-wide association studies confirm vezatin as the locus with the strongest evidence for association with endometriosis.
New
Milano, Italy. In Hum Reprod, Apr 2015
SUMMARY ANSWER: SNP rs10859871 near the vezatin (VEZT) gene was found to be significantly associated with endometriosis in general while SNPs rs17694933 and rs4141819 were associated with Stage III/IV and ovarian disease, respectively.
VEZT as a novel independent prognostic factor in gastric cancer.
In Cancer Biomark, 2014
METHODS: We examined the vezatin expression levels in 119 gastric cancer tissues and adjacent normal tissues by immunohistochemistry. Furthermore, we evaluated the expression of VEZT and its relationship with clinicopathological factors, lymphatic metastasis and prognostic value for gastric cancer.
Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.
GeneRIF
Paris, France. In J Neurosci, 2012
These results suggest a role of Vezatin in dendritic spine morphogenesis and functional synaptic maturation.
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.
Japan. In Febs Lett, 2011
Of the 407 sTMPs screened, only the interleukin-21 receptor (IL21R), vezatin (VEZT), and carbonic anhydrase XIV were cleaved at Asp344, Asp655 and Asp53, respectively.
Down-regulation of VEZT gene expression in human gastric cancer involves promoter methylation and miR-43c.
GeneRIF
Jinan, China. In Biochem Biophys Res Commun, 2011
miR-43c directly targets adherens junctions' transmembrane protein (VEZT) and suppresses VEZT protein expression.
Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.
GeneRIF
Sagamihara, Japan. In Neurosci Res, 2010
present study suggests that vezatin may regulate dendritic formation as a downstream effector of ARF6.
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
GeneRIF
Paris, France. In Embo Mol Med, 2009
vezatin associates with actin filaments at cell-cell junctions.
Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation.
GeneRIF
Paris, France. In Mech Dev, 2007
These in vitro observations reinforce the idea that homozygous vezatin-null mutants die at the time of implantation because of a defect in intercellular adhesion.
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.
Paris, France. In J Neurosci, 2007
Here, we show that the transmembrane protein usherin, the putative transmembrane protein vezatin, and the PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain-containing submembrane protein whirlin are colocalized with Vlgr1 at the stereocilia base in developing cochlear hair cells and are absent in Vlgr1-/- mice that lack the ankle links.
Vezatin, a ubiquitous protein of adherens cell-cell junctions, is exclusively expressed in germ cells in mouse testis.
Paris, France. In Reproduction, 2007
Vezatin is a transmembrane protein associated with adherens junctions and the actin cytoskeleton in most epithelial cells.
Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis.
GeneRIF
Paris, France. In Dev Biol, 2005
function of mouse vezatin in mouse blastocyst morphogenesis
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells.
Paris, France. In J Cell Sci, 2004
We have recently identified an unconventional myosin, myosin VIIa and its ligand vezatin, at the adherens junctions of polarized epithelial cells.
Myosin VI is required for E-cadherin-mediated border cell migration.
Impact
Baltimore, United States. In Nat Cell Biol, 2002
Mutations in MyoVIIA, another unconventional myosin protein, also lead to deafness, and MyoVIIA interacts with E-cadherin through a membrane protein called vezatin.
Plasma membrane components of adherens junctions (Review).
Review
Montréal, Canada. In Mol Membr Biol, 2002
This review focuses on the three known plasma membrane components of adherens junctions: E-cadherin, nectin-2 and vezatin.
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex.
Paris, France. In Embo J, 2000
Here we show that the C-terminal FERM domain of myosin VIIA binds to a novel transmembrane protein, vezatin, which we identified by a yeast two-hybrid screen.
