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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Vascular endothelial growth factor C

VEGF-C, Vascular Endothelial Growth Factor C
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, KDR, PCL, VEGF-D, HAD
Papers on VEGF-C
Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis.
Wan et al., Shiyan, China. In Mol Cell Biochem, Feb 2016
UNASSIGNED: VEGF-C is a newly identified proangiogenic protein playing an important role in vascular disease and angiogenesis.
Response to anti-VEGF-A treatment of endothelial cells in vitro.
Nicolò et al., Genova, Italy. In Exp Eye Res, Feb 2016
Cell viability and then expression and secretion of VEGF-A, VEGF-B, VEGF-C and PlGF were evaluated respectively by Real Time-PCR and ELISA.
VEGF Pathways in the Lymphatics of Healthy and Diseased Heart.
Lemström et al., München, Germany. In Microcirculation, Jan 2016
Since the discovery of angiogenic VEGF-A in 1983 and lymphangiogenic VEGF-C in 1997, an increasing amount of knowledge has accumulated on the essential roles of VEGF ligands and receptors in physiological and pathological angiogenesis and lymphangiogenesis.
Prognostic value of vascular endothelial growth factor-C and podoplanin mRNA expression in esophageal cancer.
Nikliński et al., Białystok, Poland. In Oncol Lett, Dec 2015
UNASSIGNED: Vascular endothelial growth factor-C (VEGF-C), VEGF-D, VEGF receptor-3 (VEGFR-3) and podoplanin (PDPN) are involved in the spread of cancer.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
VEGF Expression in Pancreatic Cancer and Other Malignancies: A Review of the Literature.
Săftoiu et al., In Rom J Intern Med, Jul 2015
VEGF protein family currently comprises several members: VEGF (or VEGF-A), VEGF-B, VEGF-C and VEGF-D, VEGF-F, placental growth factor (PlGF), and their receptors VEGFR-1, VEGFR-2 and VEGFR-3.
Cardiac lymphatics are heterogeneous in origin and respond to injury.
Riley et al., In Nature, Jul 2015
In the adult heart, myocardial infarction promoted a significant lymphangiogenic response, which was augmented by treatment with VEGF-C, resulting in improved cardiac function.
Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis.
Donnem et al., Tromsø, Norway. In Plos One, 2014
RESULTS: High levels of vascular endothelial growth factor C (VEGF-C, HR 1.57 95% CI 1.34-1.84)
Decreased maspin combined with elevated vascular endothelial growth factor C is associated with poor prognosis in non-small cell lung cancer.
Yang et al., Beijing, China. In Thorac Cancer, 2014
METHODS: Immunohistochemistry was performed to assay the expression of maspin and VEGF-C in primary tumor tissues, metastatic, and non-metastatic lymph nodes in 98 NSCLC patients.
Vascular endothelial growth factor C is an indicator of lymph node metastasis in thoracic esophageal squamous cellcarcinomas and its role in long-term survival after surgery.
Chen et al., Shanghai, China. In Thorac Cancer, 2014
BACKGROUND: To define the role of vascular endothelial growth factor C (VEGF-C) on lymph node (LN) metastasis of human esophageal squamous cell carcinoma (ESCC), and to investigate its impact on overall survival.
The role of angiogenic factors in endometrial cancer.
Stetkiewicz et al., Łódź, Poland. In Prz Menopauzalny, 2014
The VEGF family consists of VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and PLGF (placental growth factor).
Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock.
Wang et al., Shanghai, China. In Immunity, 2014
The surface vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C were upregulated in macrophages.
Prognostic Significance of VEGF-C Expression in Patients with Breast Cancer: A Meta-Analysis.
Li et al., Shenyang, China. In Iran J Public Health, 2014
We performed a meta-analysis of available studies to assess the association between VEGF-C expression and the ou-tcomes of breast cancer patients.
Andes virus infection of lymphatic endothelial cells causes giant cell and enhanced permeability responses that are rapamycin and vascular endothelial growth factor C sensitive.
Mackow et al., Stony Brook, United States. In J Virol, 2012
VEGF-C activation of lymphatic endothelial cell-specific VEGFR3 receptors blocked Andes virus- and VEGF-A-induced lymphatic endothelial cell permeability.
CD8+ T cells suppress viral replication in the cornea but contribute to VEGF-C-induced lymphatic vessel genesis.
Carr et al., Oklahoma City, United States. In J Immunol, 2012
CD8-positive T cells are required to eliminate virus more efficiently from the cornea but play a minimal role in immunopathology as a source of transgenic VEGF-C.
SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.
Ford et al., Aurora, United States. In J Clin Invest, 2012
A critical role for SIX1 in lymphatic dissemination of breast cancer cells, providing a direct mechanistic explanation for how VEGF-C expression is upregulated in breast cancer.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Adams et al., Münster, Germany. In Nature, 2012
By contrast, VEGFR3, the main receptor for VEGF-C, was strongly modulated by Notch.
VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.
Stacker et al., Melbourne, Australia. In Cancer Cell, 2012
Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D that are secreted by some primary tumors.
The extra domain A of fibronectin increases VEGF-C expression in colorectal carcinoma involving the PI3K/AKT signaling pathway.
Liang et al., Chongqing, China. In Plos One, 2011
The data showed that extra domain A fibronection could play a role in tumor-induced lymphangiogenesis via upregulating autocrine secretion of VEGF-C in colorectal cancer via the PI3K/Akt-dependent pathway. [extra domain a fibronectin, human]
Expression of VEGF-C/VEGFR-3 in human laryngeal squamous cell carcinomas and its significance for lymphatic metastasis.
Ju et al., Yangzhou, China. In Asian Pac J Cancer Prev, 2011
High VEGF-C gene expression is associated with lymphatic metastasis in laryngeal squamous cell carcinomas.
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