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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cadherin 5, type 2

VE-cadherin, CD144
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD31, CAN, vascular endothelial growth factor, V1a, Actin
Papers using VE-cadherin antibodies
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
Supplier
Addison Christina Lynn, In PLoS ONE, 2009
... Rabbit anti- VE-Cadherin and TSP polyclonal antibodies were from Abcam.
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
Supplier
Qin Gangjian, In PLoS ONE, 2008
... Allophycocyanin (APC) Biotin conjugated anti-mouse Flk-1, Anti-Mouse CD144 (VE-cadherin) Biotin, Streptavidin Phycoerythrin (PE) and Streptavidin Fluorescein isothiocyanate (FITC) were purchased from eBioscience (San Diego, CA, USA) ...
Pre-processing Agilent microarray data
Supplier
Ciardiello F et al., In British Journal of Cancer, 2006
... P-STAT3 (Tyr705), STAT3, P-IGF1-R (Tyr 1165,1166), IGF1R, P-MET (Tyr1234,1235), MET, HIF-1alpha, VEGFR-1, E-cadherin, caveolin, vimentin, VE-cadherin, survivin were obtained from Cell Signaling Technology, Danvers, MA, USA ...
Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells
Supplier
Deasy Bridget M. et al., In Journal of Biomedicine and Biotechnology, 2006
... primary antibodies CD34, CD146, CD44, CD73, CD105, and CD90 (BD Biosciences, San Jose, CA) and CD144 (eBioscience, San Diego, CA) followed ...
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration
Supplier
Burridge Keith et al., In The Journal of Cell Biology, 2005
... Polyclonal rabbit antibody against VE-cadherin was purchased from Cayman Chemical ...
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Papers on VE-cadherin
Localized signals that regulate transendothelial migration.
Review
New
Muller, United States. In Curr Opin Immunol, Feb 2016
Another process that is critical for TEM is transient removal of VE-cadherin from the site of TEM.
NgBR is essential for endothelial cell glycosylation and vascular development.
New
Sessa et al., New Haven, United States. In Embo Rep, Feb 2016
Loss of NgBR in endothelial cells reduces proliferation and promotes apoptosis of the cells largely through defects in the glycosylation of key endothelial proteins including VEGFR2, VE-cadherin, and CD31, and defective glycosylation can be rescued by treatment with the end product of cisPTase activity, dolichol phosphate.
Analysis of cell-cell junctions in human amnion and chorionic plate affected by chorioamnionitis.
New
Marzioni et al., Ancona, Italy. In Histol Histopathol, Feb 2016
We studied the protein expression (by immunohistochemistry and western blotting) and the mRNA levels (by RT-PCR) of some junction proteins such as Zonula Occludens-1 (ZO-1), occludin, VE-cadherin and β-catenin in fetal membranes from women with chorioamnionitis compared to those membranes derived from idiopathic pregnancies.
FGF-2 inhibits Endothelial-Mesenchymal Transition through microRNA-20a-mediated repression of canonical TGF-β Signaling.
New
Krenning et al., Groningen, Netherlands. In J Cell Sci, Feb 2016
We found that miR-20a is decreased during EndMT and ectopic expression of miR-20a inhibits EndMT induction.TGFβ1 induces cellular hypertrophy in human umbilical vein endothelial cells and abrogates VE-Cadherin expression, reduces endothelial sprouting capacity and induces the expression of the mesenchymal marker SM22α.
Communication from the periphery to the hypothalamus through the blood-brain barrier: an in vitro platform.
New
Lamghari et al., Porto, Portugal. In Int J Pharm, Jan 2016
The expression of junctional molecules as claudin-5, ZO-1, occludin and VE-cadherin was observed in the bEnd.3
Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker?
Review
New
Unsur et al., Kayseri, Turkey. In World J Transplant, Jan 2016
EMPs having CD144, CD 146, CD31(+)/CD41(-), CD51 and CD105 may be used to evaluate the vascular endothelial cell damage and determine asymptomatic patients who might be at higher risk of developing cardiovascular disease in CKD and renal transplant.
VE-cadherin in vascular development: a coordinator of cell signaling and tissue morphogenesis.
Review
Hogan et al., Brisbane, Australia. In Curr Top Dev Biol, 2014
One key adhesion molecule is the adherens junctional protein vascular endothelial cadherin (VE-cadherin).
Identification of plasma vascular endothelia-cadherin as a biomarker for coronary artery disease in Type 2 diabetes mellitus patients.
Hu et al., Beijing, China. In Int J Clin Exp Med, 2014
METHODS: VE-cadherin levels were analyzed by enzyme-linked immunosorbent assays.
Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio).
Review
Wen et al., Toronto, Canada. In J Cereb Blood Flow Metab, 2014
A number of cerebrovascular disorders are associated with mutations in genes that otherwise regulate vascular integrity through VE-cadherin dynamics.
Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells.
Impact
Keller et al., Toronto, Canada. In Nat Biotechnol, 2014
Here we show that both hematopoietic programs transition through hemogenic endothelial intermediates and develop from KDR(+)CD34(-)CD144(-) progenitors that are distinguished by CD235a expression.
The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis.
Impact
Gerhardt et al., London, United Kingdom. In Nat Cell Biol, 2014
By combining computational modelling with experimentation, we identify that Notch/VEGFR-regulated differential dynamics of VE-cadherin junctions drive functional endothelial cell rearrangements during sprouting.
Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin.
Impact
Vestweber et al., Münster, Germany. In Nat Immunol, 2014
Tyrosine phosphorylation of the adhesion molecule VE-cadherin is assumed to affect endothelial junction integrity.
Endothelial permeability and VE-cadherin: a wacky comradeship.
Review
Gavard, In Cell Adh Migr, 2013
The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer between blood vessel and irrigated tissues.
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.
Impact
Xia et al., Oklahoma City, United States. In Nature, 2013
Mice lacking fibroblastic reticular cell PDPN or platelet CLEC-2 exhibited significantly reduced levels of VE-cadherin (also known as CDH5), which is essential for overall vascular integrity, on HEVs.
Retinoic acid signaling is essential for embryonic hematopoietic stem cell development.
Impact
Keller et al., Toronto, Canada. In Cell, 2013
Here, we show that activation of retinoic acid (RA) signaling in aorta-gonad-mesonephros-derived HE ex vivo dramatically enhanced its HSC potential, whereas conditional inactivation of the RA metabolizing enzyme retinal dehydrogenase 2 in VE-cadherin expressing endothelial cells in vivo abrogated HSC development.
p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.
GeneRIF
Luscinskas et al., Boston, United States. In Am J Physiol Cell Physiol, 2012
p120 overexpression inhibits neutrophil migration independently of an effect on RhoA or Rac and instead blocks migration by preventing VE-cadherin tyrosine phosphorylation and association of active Src with the VE-cadherin complex
A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)α in endothelial cells.
GeneRIF
Walker et al., Leeds, United Kingdom. In Mol Biol Cell, 2012
A VE-cadherin-PAR3-alpha-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A(2)alpha in endothelial cells.
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
GeneRIF
de Rooij et al., Utrecht, Netherlands. In J Cell Biol, 2012
Results implicate Vinculin-dependent VE-cadherin mechanosensing in endothelial processes such as leukocyte extravasation and angiogenesis.
Vitronectin increases vascular permeability by promoting VE-cadherin internalization at cell junctions.
GeneRIF
Wu et al., China. In Plos One, 2011
VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking.
Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: evidence from atomic force microscopy and biochemical studies.
GeneRIF
Oberhauser et al., Galveston, United States. In Plos Negl Trop Dis, 2011
Upon infection by spotted fever group rickettsiae, phosphorylation of VE-cadherin directly attenuates homophilic protein-protein interactions at the endothelial adherens junctions dysfunction causing microvascular hyperpermeability.
More papers using VE-cadherin antibodies
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
Supplier
Xu Qingbo et al., In The Journal of Cell Biology, 2005
... against CD31 (rat), Flk-1, and Flt-1 were purchased from Abcam; antibodies against CD106 (rat) and CD144 (rat) were obtained from BD Biosciences; antibody against CD133 (rat) ...
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Supplier
Keaney John F. et al., In The Journal of Cell Biology, 2004
... Anti-EGFR, GS-28, SHP-2, and VE-cadherin were purchased from Santa Cruz Biotechnology, Inc ...
Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription.
Supplier
Gaetano Carlo, In PLoS ONE, 2003
... Anti-VE-cadherin antibody was obtained from Cell Signaling (Cell Signaling, Danvers, MA, ...
Growth hormone and epidermal growth factor in salivary glands of giant and dwarf transgenic mice
Supplier
Sawa Yoshihiko et al., In Acta Histochemica et Cytochemica, 2003
... rat anti-mouse E-cadherin (R&D Systems), polyclonal rabbit anti-mouse N-cadherin (Abcam, Cambridge, UK), polyclonal rabbit anti-mouse VE-cadherin (Abcam), and polyclonal goat anti-klotho ...
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them
Supplier
Springer Timothy A. et al., In The Journal of Cell Biology, 2000
... Anti–VE-cadherin (clone 55-7H1) and MCP-1 were obtained from BD Biosciences.
Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
Supplier
Giancotti Filippo G. et al., In The Journal of Cell Biology, 1997
... and anti-Merlin (A-19, C-18; Santa Cruz Biotechnology, Inc.); anti–β-actin (Sigma-Aldrich); anti–phospho-ERK (Cell Signaling); anti-Ras and anti–VE-cadherin (BD Biosciences); and anti-HA (Babco) ...
Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities.
Supplier
Cordes Nils, In PLoS ONE, 1990
... from Sigma-Aldrich (Germany), mouse anti-VE-cadherin was from Immunotech (France) and R&D systems (Minneapolis, MN), goat anti-VE-cadherin were from Santa Cruz Biotechnology (Santa Cruz, CA), rabbit ...
Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody
Supplier
Fujinaga Yukako et al., In The Journal of Cell Biology, 1983
An anti–VE-cadherin antibody was purchased from Santa Cruz Biotechnology, Inc ...
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